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  • NIH VideoCast - HHS-Secretary`s Advisory Committee on Blood & Tissue Safety & Availability (ACBTSA) - April 2015 (Day 1)
    • - HHS Office of the Assistant Secretary for Health (2015/04/10)
    • - Category : Advisory Board Meetings
    HHS Advisory Committee on Blood & Tissue Safety & Availability ？？？ Meeting on Tissue Tracking and Traceability

    For more information go to http://www.hhs.gov

    NIH VideoCast - HHS-Secretary`s Advisory Committee on Blood & Tissue Safety & Availability (ACBTSA) - April 2015 (Day 1)

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  • NIH VideoCast - Demystifying Medicine 2015 - Infertility: an Increasing Problem Prompting Remarkable Advances
    • - Alan DeCherney, MD, NICHD, NIH and Germaine Buck Louis, PhD, MS, NICHD, NIH (2015/04/10)
    • - Category : Demystifying Medicine
    The 2015 Demystifying Medicine Series, which is jointly sponsored by FAES and NIH, will begin January 6th and includes the presentation of patients, pathology, diagnosis and therapy in the context of major disease problems and current research. Primarily directed toward Ph.D. students, clinicians and program managers, the course is designed to help bridge the gap between advances in biology and their application to major human diseases. Each session includes clinical and basic science components presented by NIH staff and invitees. All students, fellows and staff are welcome, as well.

    For more information go to http://demystifyingmedicine.od.nih.gov/

    NIH VideoCast - Demystifying Medicine 2015 - Infertility: an Increasing Problem Prompting Remarkable Advances

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  • NIH VideoCast - Contemporary Clinical Medicine: Great Teachers: Epidemiologic, Neuroimaging and Genomic Research into Chronic Neurotoxic Encephalopathy from the 1991 Persian Gulf War
    • - Robert W. Haley, MD, FACP, FACE, Professor and Holder of the Distinguished Chair in Medical Research, Honoring America`s Gulf War Veterans and Chief, Division of Epidemiology, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas (2015/04/10)
    • - Category : Clinical Center Grand Rounds
    Contemporary Clinical Medicine: Great Teachers: Epidemiologic, Neuroimaging and Genomic Research into Chronic Neurotoxic Encephalopathy from the 1991 Persian Gulf War

    For more information go to http://www.cc.nih.gov/about/news/grcurrent.html

    NIH VideoCast - Contemporary Clinical Medicine: Great Teachers: Epidemiologic, Neuroimaging and Genomic Research into Chronic Neurotoxic Encephalopathy from the 1991 Persian Gulf War

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  • NIH VideoCast - Linking neuronal activity and gene expression: Ca nanodomains and long-range signaling
    • - Richard Tsien, D.Phil., NYU Neuroscience Institute (2015/04/09)
    • - Category : Neuroscience
    Neuroscience Seminar Series

    NIH VideoCast - Linking neuronal activity and gene expression: Ca nanodomains and long-range signaling

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  • NIH VideoCast - 2015 NIMH Autism Awareness Special Lecture
    • - Dr. Thomas Insel (2015/04/09)
    • - Category : Neuroscience
    NIMH is hosting a special lecture to recognize National Autism Awareness Month.

    NIH VideoCast - 2015 NIMH Autism Awareness Special Lecture

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  • NIH VideoCast - CC Ethics Rounds: Competing Protocols for the Same Patient Population: Who Should Choose?
    • - Robert Silbergleit, MD Professor, Emergency Medicine, University of Michigan Health System and Case Presenter: Jamie Roberts, MA, MPH Former Clinical Trial Recruitment Specialist, NINDS, NIH; Senior Clinical Project Manager, Clinical Trials Transformation Initiative, Duke Clinical Research Institute, Duke University (2015/04/03)
    • - Category : Clinical Center Grand Rounds
    CC Ethics Rounds: Competing Protocols for the Same Patient Population: Who Should Choose?

    For more information go to http://www.cc.nih.gov/about/news/grcurrent.html

    NIH VideoCast - CC Ethics Rounds: Competing Protocols for the Same Patient Population: Who Should Choose?

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  • NIH VideoCast - Initiation and Regulation of Toll-like Receptor Signal Transduction
    • - Dr. Jonathan Kagan, Harvard Medical School (2015/04/03)
    • - Category : Immunology
    Immunology Interest Group

    Dr. Jon Kagan is an Associate Professor of Pediatrics at Harvard Medical School and the Shwachman Chair in Gastroenterology at Boston Children`s Hospital. He received his Ph.D. from Yale University in 2003 then conducted postdoctoral research in the laboratory of Ruslan Medzhitov until 2007. Jon studies the mechanisms of Pattern Recognition Receptor (PRR) signaling, with a focus on the role of cellular localization in controlling pathway activation. During his postdoctoral work, he made the important discovery that the activation of the MyD88 and TRIF branches of the LPS/TLR4 pathway is a sequential event (Nature Immunology. 2008; 9(4):361-8.), establishing the premise that sorting adapters recruited to an activated PRR dictate the location and timing of signaling adaptor recruitment and pathway activation. Since starting his own lab at Harvard, Jon has extended this work to identify the mechanism by which the Tirap sorting adaptor diversifies the sites of TLR signaling (Cell. 2014 Feb 13;156(4):705-16), the characterization of CD14 as a microbe-induced trafficking adapter (Cell. 2011 Nov 11;147(4):868-80) and the recent discovery of peroxisomes as a new site of antiviral signal transduction (Nature Immunology 2014 Aug;15(8):717-26).

    For more information go to http://sigs.nih.gov/immunology/Pages/default.aspx

    NIH VideoCast - Initiation and Regulation of Toll-like Receptor Signal Transduction

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  • NIH VideoCast - Construction of Protein PTM Networks by Data Mining, Text Mining, and Ontology Integration: Application to Multi-Faceted Disease Analysis
    • - Dr. Cathy Wu, Edward G. Jefferson Chair and Professor and Director of the Center for Bioinformatics & Computational Biology (CBCB), University of Delaware Director of the Protein Information Resource(PIR) and the North east Bioinformatics Collaborative Steering Committee Adjunct Professor at the Georgetown University Medical Center (2015/04/03)
    • - Category : Proteomics
    Perturbations in post-translational modifications (PTMs) and their downstream effects are recognized as key drivers of disease. We have developed iPTMnet, employing an integrative bioinformatics approach？？？combining text mining, data mining, and ontological representation to capture rich PTM information？？？for PTM network and disease discovery. Text mining tools are used for full-scale mining of PubMed abstracts and PMC Open Access articles to identify PTM information (kinase, substrate, and site) and phosphorylation-dependent protein-protein interactions (PPIs) in their biological context, including disease consequences. Experimentally observed PTMs, including high-throughput proteomic data from curated PTM databases, are incorporated. Ontologies are used for knowledge representation, particularly the Protein Ontology (PRO) for representation of PTM proteoforms and complexes. The web portal (http://proteininformationresource.org/iPTMnet) supports online search and visual analysis, including multiple-sequence alignment views for comparison of PTM forms across organisms and Cytoscape visualization of PTM enzyme-substrate and PPI relationships in PTM interaction networks. We are conducting use cases for PTM-disease discovery. First, we analyzed phosphorylation-dependent PPIs related to the PI3K/AKT/mTOR pathway, which is deregulated in many cancers and is targeted by therapeutic kinase inhibitors. We classified interactions as pro- and anti-oncogenic to indicate potential mechanisms of kinase-inhibitor resistance. Second, we made a knowledge map of beta-catenin PTM proteoforms to interpret patterns of mutations in PTM sites occurring in different types of cancer, revealing multiple mechanisms through which mutations in beta-catenin PTM sites contribute to cancer. Finally, we are exploring the phosphorylation of pyruvate dehydrogenase (PDHA1), a mediator of the Warburg effect in cancer whose phosphorylation levels span a 64-fold range in breast cancer patient samples from phosphoproteomic data CPTAC. We are investigating the levels and activity of PDHA1 kinases and phosphatases in the same samples using genomic, transcriptomic (mRNA and miRNA), and proteomic data to gain insight into the efficacy of existing anti-cancer drugs that target PDHA1 phosphorylation.

    For more information go to http://proteome.nih.gov

    NIH VideoCast - Construction of Protein PTM Networks by Data Mining, Text Mining, and Ontology Integration: Application to Multi-Faceted Disease Analysis

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  • NIH VideoCast - Demystifying Medicine 2015 - Bladder Cancer: Chromosomes and a Major Disease
    • - Andrea Apolo, MD, NCI, NIH and Lyuba Varticovski, MD, NCI, NIH (2015/04/02)
    • - Category : Demystifying Medicine
    The 2015 Demystifying Medicine Series, which is jointly sponsored by FAES and NIH, will begin January 6th and includes the presentation of patients, pathology, diagnosis and therapy in the context of major disease problems and current research. Primarily directed toward Ph.D. students, clinicians and program managers, the course is designed to help bridge the gap between advances in biology and their application to major human diseases. Each session includes clinical and basic science components presented by NIH staff and invitees. All students, fellows and staff are welcome, as well.

    For more information go to http://demystifyingmedicine.od.nih.gov/

    NIH VideoCast - Demystifying Medicine 2015 - Bladder Cancer: Chromosomes and a Major Disease

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  • NIH VideoCast - Pediatric Multiple Organ Dysfunction Syndrome Conference (Day 1)
    • - NICHD, NIH (2015/04/01)
    • - Category : Conferences
    Multiorgan dysfunction syndrome is the leading cause of death in children in pediatric intensive care units. Further, organ dysfunction is being utilized with increasing frequency as a quality index.

    At this workshop, attendees and participants will discuss the epidemiology, etiologies, pathophysiology, scoring systems, and outcomes for multiorgan dysfunction syndrome in children. The workshop will enable researchers and clinicians to better understand the syndrome, identify knowledge gaps, and target promising therapies for further study.

    For more information go to http://www.nichd.nih.gov/about/meetings/2015/Pages/032715.aspx

    NIH VideoCast - Pediatric Multiple Organ Dysfunction Syndrome Conference (Day 1)

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  • NIH VideoCast - Contemporary Clinical Medicine: Great Teachers: Autoimmunity: The Once and Future History of an Idea
    • - Paul H. Plotz, MD, Senior Clinician, NIAMS and Scientist Emeritus, NIH (2015/03/31)
    • - Category : Clinical Center Grand Rounds
    Contemporary Clinical Medicine: Great Teachers: Autoimmunity: The Once and Future History of an Idea

    For more information go to http://www.cc.nih.gov/about/news/grcurrent.html

    NIH VideoCast - Contemporary Clinical Medicine: Great Teachers: Autoimmunity: The Once and Future History of an Idea

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  • NIH VideoCast - The extraordinary bacterial Type VI secretion machine
    • - John Mekalanos, Ph.D., Adele H. Lehman Professor of Microbiology and Molecular Genetics; Chair, Department of Microbiology and Molecular Genetics; and Professor, Department of Microbiology and Molecular Genetics at Harvard Medical School (2015/03/31)
    • - Category : WALS - Wednesday Afternoon Lectures
    Wednesday Afternoon Lecture Series

    Bacterial pathogenesis typically involves multiple factors that influence the infection process. Type VI Secretion Systems (T6SS) are nanomachines that deliver proteins called effectors into target cells. The machines are evolutionarily related to the contractile tails of bacteriophages but are located within the cell cytosol. Through dynamic conformational changes in tail sheath-like structure, these machines deliver payloads of toxic effector proteins into target cells during a time interval that is likely less than five milliseconds. By defining biochemical activity of effectors, one can reveal how many of these proteins might kill other bacterial cells (e.g., by digesting peptidoglycan) as well as mammalian host cells (e.g., by cross-linking G actin) during pathogenesis. Furthermore, emerging evidence suggest that T6SS effectors are antibacterial both in vitro and in vivo (i.e., during infection) suggesting that these may influence in host colonization process by eliminating competing members of the commensal microbiota. The Mekalanos lab has also investigated the transcriptional changes that occur in prey cells that are undergoing attack by the T6SS and its effectors. Remarkably, lethal attacks from competing T6SS+ bacterial species results in the production of reactive oxygen species (ROS) in prey cells when measured using several different types of reporters. ROS was induced in E. coli when exposed to not only T6SS effectors, but also P1 phage and the antibiotic polymyxin B. His lab concludes that generation of ROS is a general outcome of contact-dependent interactions of aggressive competing bacterial species and may contribute to the lethality of such attacks.

    For more information go to http://wals.od.nih.gov

    NIH VideoCast - The extraordinary bacterial Type VI secretion machine

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  • NIH VideoCast - NIH BD2K Think Tank - EHR Data Methodologies in Clinical Research: Perspectives from Field
    • - Elaine Collier, NIH, Gina Wei, NIH (2015/03/31)
    • - Category : Conferences
    This workshop will serve as a think tank to convene a small number of experts to specifically address methods for optimizing the robustness and use of data from the Electronic Health Records (EHR) for a variety of clinical research purposes that fall within NIH？？？s domain. The think tank will recommend current strategies to address robustness and validity concerns or where new methodologies are needed to address these types of research studies. Traditional study design and statistical methods may need to be rethought in the context of using EHR data for research analysis. Where applicable, the think tank will take into account and build upon recommendations from the NIH workshop on ？？？Enabling Research Use of Clinical Data？？？ http://bd2k.nih.gov/pdf/ClinicalDataWorkshopReport_March2014.pdf.

    NIH VideoCast - NIH BD2K Think Tank - EHR Data Methodologies in Clinical Research: Perspectives from Field

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  • NIH VideoCast - Advisory Committee to the Director - December 2014 (Day 1)
    • - Office of the Director, NIH (2015/03/31)
    • - Category : Advisory Committee to the Director of the NIH
    ACD full board meeting

    For more information go to http://acd.od.nih.gov

    NIH VideoCast - Advisory Committee to the Director - December 2014 (Day 1)

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  • NIH VideoCast - Recombinant DNA Advisory Board Meeting - December 2014
    • - Office of Science Policy, NIH (2015/03/31)
    • - Category : Recombinant DNA Advisory Committee
    RAC Advisory Board

    NIH VideoCast - Recombinant DNA Advisory Board Meeting - December 2014

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  • NIH VideoCast - Anita B. Roberts Lecture: Neurotrophic Factor 慣-1: A Key Regulator of Neuroprotection, Depression and Cancer Metastasis
    • - Dr. Peng Loh, Laboratory of Developmental Neurobiology, NICHD, NIH (2015/03/31)
    • - Category : Anita B. Roberts - Distinguished Women Scientists
    Anita B. Roberts Lecture Series

    Dr. Peng Loh will give the fifteenth lecture in the Anita B. Roberts lecture series, which highlights outstanding research achievements of women scientists in the Intramural Research Program.

    The Anita B. Roberts Lecture Series, "Distinguished Women Scientists at NIH, highlights outstanding research achievements of women scientists at the NIH. The seminar is dedicated to Dr. Anita Roberts and honors her role as an exceptional mentor and scientist.

    Anita joined the NIH in 1976 and spent 30 years at NCI, rising to Chief of the Laboratory of Cell Regulation and Carcinogenesis. She died of gastric cancer in May 2006, leaving a legacy that touched both the professional and personal lives of all who knew her. Her work focused primarily on TGF-beta and its role in the growth of epithelial and lymphoid cells. In 2003, Thomas Scientific`s Science Watch listed her among the 50 most-cited scientists during 1982 to 2002, a feature called "Twenty Years of Citation Superstars."

    Anita was a superstar to many for her mentoring talent and her ability to balance family and work life. Her successful lab was well known for meeting family needs and for providing an environment both intellectually and emotionally enriching. The lecture series in her name serves to highlight the fact that the NIH recognizes the value and necessity of a supportive workplace.

    For more information go to http://sigs.nih.gov/wsa/Pages/Archives.aspx

    NIH VideoCast - Anita B. Roberts Lecture: Neurotrophic Factor 慣-1: A Key Regulator of Neuroprotection, Depression and Cancer Metastasis

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  • NIH VideoCast - Immunology of Protection from Ebola Virus Infection
    • - NIAID/NIH, FDA, BARDA, DoD, CDC (2015/03/31)
    • - Category : Conferences
    The goal of this workshop, which is co-sponsored by FDA, NIAID, DOD, CDC, and BARDA, is to discuss important aspects of Ebola virus and vaccine immunology in order to inform future clinical, scientific and regulatory decision-making related to vaccines against Ebola.

    For more information go to https://respond.niaid.nih.gov/conferences/Ebola/Pages/Immunology%20of%20Protection%20from%20Ebola%20Virus%20Infection.aspx

    NIH VideoCast - Immunology of Protection from Ebola Virus Infection

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  • NIH VideoCast - Advisory Committee to the Director - December 2014 (Day 2)
    • - Office of the Director, NIH (2015/03/31)
    • - Category : Advisory Committee to the Director of the NIH
    ACD full board meeting

    For more information go to http://acd.od.nih.gov

    NIH VideoCast - Advisory Committee to the Director - December 2014 (Day 2)

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  • NIH VideoCast - 2015 Dietary Guidelines Advisory Committee (Meeting 7)
    • - HHS/ODPHP (2015/03/31)
    • - Category : Advisory Board Meetings
    This is the seventh and last meeting of the 2015 Dietary Guidelines Advisory Committee (DGAC). The DGAC will develop an advisory report for the Secretaries of Health and Human Services and of Agriculture. This Committee？？？s advisory report will provide the scientific basis for the 2015 Dietary Guidelines for Americans policy document developed by the Federal government.

    There was a problem with the audio at the very beginning, but fortunately, this was completely resolved before the DGAC began presenting or deliberating.

    NIH VideoCast - 2015 Dietary Guidelines Advisory Committee (Meeting 7)

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  • NIH VideoCast - Scientific Management Review Board - December 2014
    • - Office of the Director, NIH (2015/03/31)
    • - Category : Scientific Management Review Board
    Full Board Meeting

    For more information go to http://smrb.od.nih.gov

    NIH VideoCast - Scientific Management Review Board - December 2014

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