전체 8345
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- NIH VideoCast - Heterogeneity of Tuberculosis
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- - Joanne Flynn, Ph.D, Professor, Department of Microbiology and Molecular Genetics, University of Pittsburgh (2015/03/31)
- - Category : Immunology
- Immunology Interest Group
Dr. JoAnne Flynn received her PhD from the University of California, Berkeley, and after completing her post-doctoral fellowships at Scripps and the Albert Einstein College of Medicine, JoAnne joined the faculty at the University of Pittsburgh in 1994. JoAnne？？？s primary research is focused on studying the host-pathogen interaction. Her laboratory investigates the immune mechanisms that are required for protection against Mycobacterium tuberculosis, the causative agent of tuberculosis (TB). One third of the world is infected with Mycobacterium tuberculosis, yet only 10% will develop clinical disease, while 90% of infected individuals will go on to develop latent TB. However, very little is known about what distinguishes individuals who will develop active TB from those whose infection will remain latent for decades. Using both mouse and non-human primate models, JoAnne？？？s laboratory has made ground-breaking discoveries defining the local immune responses that determine the clinical outcome of infection. Her research demonstrated that each granuloma within an individual is heterogenous with respect to the total cell number, proportion of T cells, types of cytokines produced and bacterial burden. Her primary goal is to understand why the immune response produces different results in different granulomas, so that the appropriate immune mechanisms can be harnessed to develop effective vaccines.
For more information go to http://sigs.nih.gov/immunology/Pages/default.aspx
NIH VideoCast - Heterogeneity of Tuberculosis
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- NIH VideoCast - Pediatric Multiple Organ Dysfunction Syndrome Conference (Day 2)
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- - NICHD, NIH (2015/03/31)
- - Category : Conferences
- Multiorgan dysfunction syndrome is the leading cause of death in children in pediatric intensive care units. Further, organ dysfunction is being utilized with increasing frequency as a quality index.
At this workshop, attendees and participants will discuss the epidemiology, etiologies, pathophysiology, scoring systems, and outcomes for multiorgan dysfunction syndrome in children. The workshop will enable researchers and clinicians to better understand the syndrome, identify knowledge gaps, and target promising therapies for further study.
For more information go to http://www.nichd.nih.gov/about/meetings/2015/Pages/032715.aspx
NIH VideoCast - Pediatric Multiple Organ Dysfunction Syndrome Conference (Day 2)
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- NIH VideoCast - Membrane fusion mediated by SNARE proteins
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- - Reinhard Jahn, Ph.D., Max Planck Institute for Biophysical Chemistry (2015/03/31)
- - Category : Neuroscience
- Neuroscience Seminar Series
Eukaryotic cells are compartmentalized into membrane-bound organelles. Membrane-impermeant macromolecules are transported from one compartment to another, and in and out of cells, without compromising membrane integrity. Furthermore, organelles need to be generated continuously during growth. To achieve these goals, elaborate mechanisms evolved for budding, splitting, and fusion of organelles and of whole cells without leakage of intraorganellar content or disturbance of the asymmetry of the surrounding membranes. Dr. Jahn？？？s Lab is mainly interested in the molecular mechanisms of membrane fusion with a focus on exocytosis of synaptic vesicles and fusion of endosomes. In recent years it has become clear that most, and perhaps all, intracellular membrane fusion events are mediated by sets of evolutionarily conserved membrane proteins. Among these, the SNARE proteins are the best candidates for catalyzing the fusion reaction. SNARE proteins are abundant on intracellular membranes and readily form stable complexes. It is currently thought that these proteins operate as "nanomachines" which force the membranes together and thus initiate membrane fusion. SNARE proteins interact with a long and still growing list of other proteins that regulate their conformation and control their availability for the fusion reaction. They study membrane fusion using a variety of complementary experimental approaches. They include an analysis of SNAREs and SNARE-interacting proteins with biochemical and biophysical techniques, correlation of structure with function of SNAREs in yeast, study of vesicle fusion using native and artificial membranes, characterization of how exo- and endocytotic sites at the plasma membrane are organized, and measurement of exocytosis with electrophysiological methods. Furthermore, they are interested to find out how neurotransmitters are sequestered and stored in synaptic vesicles.
NIH VideoCast - Membrane fusion mediated by SNARE proteins
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- The Many Guises and Disguises of Follicular Lymphoma
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- - Rosalind Segal, M.D., Ph.D., Department of Neurobiology, Harvard University Medical School (2014/12/31)
- - Category : Neuroscience
- Neuroscience Seminar Series
Dr. Segal received her PhD in 1985 from Rockefeller University and her MD in 1986 from Cornell University Medical College, followed by a residency in the Harvard Neurology Program. As a postdoctoral fellow at Massachusetts Institute of Technology, she investigated the role of nerve growth factors in regulating cerebellar development and tumor formation. She joined DFCI in 1998, where she is principally involved in laboratory research on nervous system development.
The Many Guises and Disguises of Follicular Lymphoma
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- Translation Science: Exposing a Deadly Difference (NIH-Only)
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- - Dr. Rezvan Ameli, NIMH, NIH (2014/12/30)
- - Category : Focus on You Wellness
- Focus on You Wellness Lecture
The Office of Research Services (ORS) Division of Amenities and Transportation Services (DATS) in partnership with the National Institute on Minority Health and Health Disparities (NIMHD), the National Institutes of Nursing Research (NINR), and the National Institute of Mental Health (NIMH) are proud to present the second of a special two-part Focus on You Lecture Series:
Cultivating Mindfulness at the Holidays
Speaker: Dr. Rezvan Ameli, NIMH, NIH
Dr. Rezvan Ameli will lead an interactive seminar that introduces the definition of mindfulness and explains its growth in popularity as well as the general trends behind it. She will also discuss how to reduce stress at the holidays and the topic of conscious consumption including conscious eating. Attendees will have the opportunity to participate in mindfulness exercises in a group setting.
Translation Science: Exposing a Deadly Difference (NIH-Only)
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- Genetic Predictors of RAF/MEK Dependence (NIH-Only)
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- - Rosalind Segal, M.D., Ph.D., Department of Neurobiology, Harvard University Medical School (2014/12/30)
- - Category : Neuroscience
- Neuroscience Seminar Series
Dr. Segal received her PhD in 1985 from Rockefeller University and her MD in 1986 from Cornell University Medical College, followed by a residency in the Harvard Neurology Program. As a postdoctoral fellow at Massachusetts Institute of Technology, she investigated the role of nerve growth factors in regulating cerebellar development and tumor formation. She joined DFCI in 1998, where she is principally involved in laboratory research on nervous system development.
Genetic Predictors of RAF/MEK Dependence (NIH-Only)
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- Synaptic Transmission at the Ribbon Synapses of the Eye and Ear
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- - Rosalind Segal, M.D., Ph.D., Department of Neurobiology, Harvard University Medical School (2014/12/27)
- - Category : Neuroscience
- Neuroscience Seminar Series
Dr. Segal received her PhD in 1985 from Rockefeller University and her MD in 1986 from Cornell University Medical College, followed by a residency in the Harvard Neurology Program. As a postdoctoral fellow at Massachusetts Institute of Technology, she investigated the role of nerve growth factors in regulating cerebellar development and tumor formation. She joined DFCI in 1998, where she is principally involved in laboratory research on nervous system development.
Synaptic Transmission at the Ribbon Synapses of the Eye and Ear
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- NCI Translational Working Group Pathways: Application in Symptom Management
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- - Dr. Rezvan Ameli, NIMH, NIH (2014/12/25)
- - Category : Focus on You Wellness
- Focus on You Wellness Lecture
The Office of Research Services (ORS) Division of Amenities and Transportation Services (DATS) in partnership with the National Institute on Minority Health and Health Disparities (NIMHD), the National Institutes of Nursing Research (NINR), and the National Institute of Mental Health (NIMH) are proud to present the second of a special two-part Focus on You Lecture Series:
Cultivating Mindfulness at the Holidays
Speaker: Dr. Rezvan Ameli, NIMH, NIH
Dr. Rezvan Ameli will lead an interactive seminar that introduces the definition of mindfulness and explains its growth in popularity as well as the general trends behind it. She will also discuss how to reduce stress at the holidays and the topic of conscious consumption including conscious eating. Attendees will have the opportunity to participate in mindfulness exercises in a group setting.
NCI Translational Working Group Pathways: Application in Symptom Management
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- Synaptic Transmission at the Ribbon Synapses of the Eye and Ear
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- - Rosalind Segal, M.D., Ph.D., Department of Neurobiology, Harvard University Medical School (2014/12/25)
- - Category : Neuroscience
- Neuroscience Seminar Series
Dr. Segal received her PhD in 1985 from Rockefeller University and her MD in 1986 from Cornell University Medical College, followed by a residency in the Harvard Neurology Program. As a postdoctoral fellow at Massachusetts Institute of Technology, she investigated the role of nerve growth factors in regulating cerebellar development and tumor formation. She joined DFCI in 1998, where she is principally involved in laboratory research on nervous system development.
Synaptic Transmission at the Ribbon Synapses of the Eye and Ear
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- Translational Trials and Tribulations (NIH-Only)
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- - Dr. Rezvan Ameli, NIMH, NIH (2014/12/24)
- - Category : Focus on You Wellness
- Focus on You Wellness Lecture
The Office of Research Services (ORS) Division of Amenities and Transportation Services (DATS) in partnership with the National Institute on Minority Health and Health Disparities (NIMHD), the National Institutes of Nursing Research (NINR), and the National Institute of Mental Health (NIMH) are proud to present the second of a special two-part Focus on You Lecture Series:
Cultivating Mindfulness at the Holidays
Speaker: Dr. Rezvan Ameli, NIMH, NIH
Dr. Rezvan Ameli will lead an interactive seminar that introduces the definition of mindfulness and explains its growth in popularity as well as the general trends behind it. She will also discuss how to reduce stress at the holidays and the topic of conscious consumption including conscious eating. Attendees will have the opportunity to participate in mindfulness exercises in a group setting.
Translational Trials and Tribulations (NIH-Only)
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- Synaptic Transmission at the Ribbon Synapses of the Eye and Ear
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- - Rosalind Segal, M.D., Ph.D., Department of Neurobiology, Harvard University Medical School (2014/12/23)
- - Category : Neuroscience
- Neuroscience Seminar Series
Dr. Segal received her PhD in 1985 from Rockefeller University and her MD in 1986 from Cornell University Medical College, followed by a residency in the Harvard Neurology Program. As a postdoctoral fellow at Massachusetts Institute of Technology, she investigated the role of nerve growth factors in regulating cerebellar development and tumor formation. She joined DFCI in 1998, where she is principally involved in laboratory research on nervous system development.
Synaptic Transmission at the Ribbon Synapses of the Eye and Ear
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- Molecular Mechanisms of Cellular Motility and Cytokinesis
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- - Joseph Anthony Movshon, Ph.D., Center for Neural Science, New York University (2014/12/18)
- - Category : Neuroscience
- Neuroscience Seminar Series
Dr. Joseph Anthony Movshon received his doctorate from Cambridge University, where he studied visual neurophysiology and psychophysics. He joined the faculty of the Department of Psychology at New York University in 1975, and have remained here apart from a sabbatical year spent at Oxford University. In 1986, his laboratory moved to the newly-formed Center for Neural Science.
He is interested in how the brain encodes and decodes visual information, and in the mechanisms that put that information to use in the control of behavior. His research concerns the function and development of the primate visual system, especially the visual areas of the cerebral cortex. His laboratory supports work on neurophysiology, neuroanatomy, psychophysics, and imaging; the main experimental tool is electrophysiological recording from single neurons in monkeys. They stress analytical and quantitative approaches to the study of visual receptive fields. Conceptually, much of this research draws on related work in visual psychophysics, and on computational approaches to understanding brain organization and visual processing.
His laboratory works mostly in two broad areas. The first is concerned with analysis of the functions of the visual areas of the primate cerebral cortex, with special emphasis on the roles of those areas in processing information about visual motion, form, and color. He is particularly interested in the relationships between visual signals in these areas, and the perceptual decisions and motor activity they support. The second group of projects focuses on the functional development of the cortical visual system, and on the way that development is affected by forms of abnormal early visual experience that produce a visual system disorder known as amblyopia. Much of their work seeks to uncover the links between brain activity and behavior by studying the relationship between neural activity in the visual system and its perceptual and motor consequences.
Molecular Mechanisms of Cellular Motility and Cytokinesis
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- Banburismus and Brain: A Neural Mechanism for Making Decisions
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- - Joseph Anthony Movshon, Ph.D., Center for Neural Science, New York University (2014/12/17)
- - Category : Neuroscience
- Neuroscience Seminar Series
Dr. Joseph Anthony Movshon received his doctorate from Cambridge University, where he studied visual neurophysiology and psychophysics. He joined the faculty of the Department of Psychology at New York University in 1975, and have remained here apart from a sabbatical year spent at Oxford University. In 1986, his laboratory moved to the newly-formed Center for Neural Science.
He is interested in how the brain encodes and decodes visual information, and in the mechanisms that put that information to use in the control of behavior. His research concerns the function and development of the primate visual system, especially the visual areas of the cerebral cortex. His laboratory supports work on neurophysiology, neuroanatomy, psychophysics, and imaging; the main experimental tool is electrophysiological recording from single neurons in monkeys. They stress analytical and quantitative approaches to the study of visual receptive fields. Conceptually, much of this research draws on related work in visual psychophysics, and on computational approaches to understanding brain organization and visual processing.
His laboratory works mostly in two broad areas. The first is concerned with analysis of the functions of the visual areas of the primate cerebral cortex, with special emphasis on the roles of those areas in processing information about visual motion, form, and color. He is particularly interested in the relationships between visual signals in these areas, and the perceptual decisions and motor activity they support. The second group of projects focuses on the functional development of the cortical visual system, and on the way that development is affected by forms of abnormal early visual experience that produce a visual system disorder known as amblyopia. Much of their work seeks to uncover the links between brain activity and behavior by studying the relationship between neural activity in the visual system and its perceptual and motor consequences.
Banburismus and Brain: A Neural Mechanism for Making Decisions
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- The Fourth Annual Scientific Lecture of the Asian American Heritage Month
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- - Joshua Kaplan, Ph.D., Harvard University (2014/12/09)
- - Category : Neuroscience
- Neuroscience Seminar Series
Work in Dr. Kaplan？？？s lab is focused on understanding how signals in the brain lead to particular patterns of behavior. They utilize a combination of behavioral, genetic, biochemical, imaging, and electrophysiological techniques to study signaling in the brain of the worm C. elegans. Current projects include: 1) Analysis of synaptic defects caused by mutations linked to autism. 2) Regulation of SV exo- and endocytosis. 3) Regulation of insulin and neuropeptide secretion. 4) Neuropeptide regulation of a sleep-like state. 5) Activity-regulated synaptic refinement.
The Fourth Annual Scientific Lecture of the Asian American Heritage Month
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- Nutrition and Cancer: From Genotype to Phenotype
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- - Dr. Joanne Murabito, Director, Clinic at the Framingham Heart Study, Associate Professor of Medicine at Boston University School of Medicine (2014/12/07)
- - Category : Geroscience
- The Trans-NIH GeroScience Interest Group (GSIG) cordially invites you to its fall seminar, featuring Dr. Joanne Murabito. Dr. Murabito is Director of the Clinic at the Framingham Heart Study, and she is an Associate Professor of Medicine at Boston University School of Medicine. Dr. Murabito？？？s research goals have focused on aging and reproductive traits in the Framingham Heart study and beyond. Specifically, her research program focuses on using the tools of epidemiology and high-throughput genetic platforms to better understand the natural history of aging and to detect novel pathways and mechanisms for aging-related traits. Studies in her laboratory encompass analysis of genome-wide association studies of aging phenotypes in human population samples using common and rare variant platforms; and investigation of determinants of healthy aging in the Framingham population. Dr. Murabito？？？s current projects include the epidemiology of centenarian experience in Framingham, physical activity and function, and biomarkers of frailty. She leads several international consortia dedicated to uncovering genes for aging-related traits, including age at menarche, age at natural menopause, and longevity. She collaborates with scientists at the Jackson Laboratory Nathan Shock Center of Excellence in the Basic Biology of Aging to further identify the functional relevance of human association findings. Dr. Murabito is keenly interested in how to reach older participants through novel technologies and use those technologies to maintain health. Dr. Murabito？？？s research has demonstrated that multiple genetic loci underlie reproductive aging, which are associated with many downstream aging-related disorders including obesity, DNA damage and repair and immune function.
The GeroScience Interest Group (GSIG) was formed to enhance opportunities for discussion of the intersection between the biology of aging and the biology of disease and conditions that are of interest across ICs. It is focused on basic biology, but with a longer view towards translation. If you are interested in learning more, please visit the GSIG web site http://sigs.nih.gov/geroscience/Pages/default.aspx.
Nutrition and Cancer: From Genotype to Phenotype
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- NCI Board of Scientific Advisors - March 2011
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- - NCI, NIH (2014/12/04)
- - Category : NCI Board of Scientific Advisors
- 4th Joint Meeting of the NCI Board of Scientific Advisors and the National Cancer Advisory Board
NCI Board of Scientific Advisors - March 2011
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- Is There a Link Between DNA Polymerase Beta and Cancer?
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- - Dr. Daniel Men？？ndez, Chromosome Stability Group, Genome Integrity and Structural Biology Laboratory, National Institute of Environmental Health Sciences, NIH (2014/12/02)
- - Category : DNA Repair
- DNA Repair Interest Group videoconference
Is There a Link Between DNA Polymerase Beta and Cancer?
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- Redox Reactions in Antigen Processing
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- - Andrea Ballabio, M.D., Ph.D., Baylor College of Medicine (2014/12/02)
- - Category : Neuroscience
- Neuroscience Seminar Series
Redox Reactions in Antigen Processing
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- Adventures in Mammalian Genetics (NIH-Only)
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- - Walther Mothes, Ph.D., Yale University School of Medicine (2014/11/29)
- - Category : Special
- Third Annual David Derse Memorial Lecture and Award
Adventures in Mammalian Genetics (NIH-Only)
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- Fast Food, Sit-downs and Coffee shops: Eating Healthy While Eating Out
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- - David Banks, NINR, NIH, Dr. Derrick Tabor, NIMHD, NIH, Dr. Linda Thompson, Howard University (2014/11/29)
- - Category : Focus on You Wellness
- The Office of Research Services (ORS) Division of Amenities and Transportation Services (DATS) in partnership with the National Institute on Minority Health and Health Disparities (NIMHD), the National Institutes of Nursing Research (NINR), and the National Institute of Mental Health (NIMH) are proud to present a special, two-part Focus on You Lecture Series in November and December 2014
Fast Food, Sit-downs and Coffee shops: Eating Healthy While Eating Out
