▶ It is generally recognized that antimicrobial peptides and natu-
ral products play an important role in innate host defense
mechanism of most living organisms including plants, insects,
amphibians and mammals.
▶ Antibiotics have become indispensable in the modem health care
system by assisting and complementing the natural immune
system. However, with the appearance of resistant strains,
there is a continuous search for more potent and efficient
antibiotic agents.
▶ Antibiotics act in two different ways; one by targeting the physi-
ology of the pathogen, and the other by disrupting the cellular
structure of the host cells. In the latter case of the targeting the
structure, the antibiotics are relatively safe from encountering
the resistant strains since mutations in the overall plasma-
membrane structure are less likely than variations in the
enzyme physiology within a host cell.
In order to develop of antibiotic peptides or natural products
and to understand its mechanism, the analogue antibiotic
peptides were designed and mechanisms was investigated by
using cell biology techniques.
국가
대한민국
소속기관
경북대학교 (학교)
연락처
053-950-5373 http://webbuild.knu.ac.kr/~mmel/
책임자
이동건 dglee222@knu.ac.kr
