PI3K in cancer: divergent roles of isoforms, modes of activation and therapeutic targeting
2015-01-13
org.kosen.entty.User@2e3e1d4b
김제현(jay99hur)
행사&학회소개
? Introduction?
? Multiple PI3K classes and isoforms?
? Alterations of PI3K isoforms in cancer?
? Divergent roles of class I PI3K catalytic isoforms?
? Therapeutic targeting of PI3K isoforms in cancer?
? Emerging isoform-selective PI3K inhibitors?
? Resistance and combination therapies?
? Conclusions and perspective?
? Multiple PI3K classes and isoforms?
? Alterations of PI3K isoforms in cancer?
? Divergent roles of class I PI3K catalytic isoforms?
? Therapeutic targeting of PI3K isoforms in cancer?
? Emerging isoform-selective PI3K inhibitors?
? Resistance and combination therapies?
? Conclusions and perspective?
보고서작성신청
Phosphatidylinositol 3 kinases (PI3Ks) 는 외부 자극에 대한 세포 내 신호 전달에서 중추적인 역할을 한다. 암세포에서는 PI3K signalling이 매우 활성화 되어 있다. 본 보고서는PI3K isoforms의 역할과 이를 타깃으로한 임상의 현황등을 자세히 보고하고 있다.