Defective control of pre？messenger RNA splicing in human disease
2016-01-21
org.kosen.entty.User@57836313
정다정(mrycho)
첨부파일
행사&학회소개
Abstract
Introduction
Splicing and splicing control
Shooting the pre-messenger by disrupting splicing control elements
Incapacitating the regulators
Impairing splicing factors to promote cancer
Spliceosomal proteins in MDS
An integrating hypothesis: Altered RBPs cause R loops and persistent DDR signaling that alter splicing
The epithelial？mesenchymal/mesenchymal？epithelial transition connection
The MYC splicing connection
Splicing factor addiction
Splicing control defects in neuropathological and muscle-related diseases
Advances and challenges in monitoring disease-associated changes in alternative splicing
References
Introduction
Splicing and splicing control
Shooting the pre-messenger by disrupting splicing control elements
Incapacitating the regulators
Impairing splicing factors to promote cancer
Spliceosomal proteins in MDS
An integrating hypothesis: Altered RBPs cause R loops and persistent DDR signaling that alter splicing
The epithelial？mesenchymal/mesenchymal？epithelial transition connection
The MYC splicing connection
Splicing factor addiction
Splicing control defects in neuropathological and muscle-related diseases
Advances and challenges in monitoring disease-associated changes in alternative splicing
References
보고서작성신청
pre-messenger RNA splicing/alternative splicing에 의한 인간 질병과 장애에 관한 예는 날로 증가하고 있다. 비록 많은 변화가 splicing 신호 또는 조절 시퀀스 요소에 돌연변이 발생으로 일어나지만 최근 연구는 돌연변이 된 spliceosome 구성요소와 splicing 조절 단백질의 파괴적인 효과에 주목하고 있다. 본 논문은 RNA-binding protein의 변화된 splicing 기능이 어떻게 골수형성이상증후군, 종양, 그리고 신경병리에 기여 하는지에 대한 최신지견을 다룬다.