Impact of Membrane Drug Transporters on Resistance Small-Molecule Tyrosine Kinase Inhibitors
2016-12-30
org.kosen.entty.User@1f44062f
이재옥(reallyfisher)
분야
보건의료
개최일
2016. 11.
신청자
이재옥(reallyfisher)
개최장소
URL
행사&학회소개
Abstracts
1. TKIs: Response Encounters Resistance
2. Mechanism of Action of TKIs
3. Factors Affecting Responsiveness to Oral TKIs
3-1.Drug Exposure as a Determinant of Clinical Outcome
3-2.Drug Transporters as Major Contributors to Drug Exposure
4. In Vitro Studies for the Identification and Assessment of Transporters
5. Knockout Mouse Studies To Assess the In Vivo Relevance of ABC Transporters
6. In Vitro and Knockout Mouse Studies To Assess the Role of OCT1 as a Transporter of Imatinib and Sorafenib
7. Factors Affecting Interindividual Variability of Transporter Function and Expression in Humans
7-1.Role of Genetic Transporter Variants in TKI Pharmacokinetics and Response in Humans
7-2.Role of Transporter Regulation for TKI Resistance
8. Concluding Remarks and Future Directions
1. TKIs: Response Encounters Resistance
2. Mechanism of Action of TKIs
3. Factors Affecting Responsiveness to Oral TKIs
3-1.Drug Exposure as a Determinant of Clinical Outcome
3-2.Drug Transporters as Major Contributors to Drug Exposure
4. In Vitro Studies for the Identification and Assessment of Transporters
5. Knockout Mouse Studies To Assess the In Vivo Relevance of ABC Transporters
6. In Vitro and Knockout Mouse Studies To Assess the Role of OCT1 as a Transporter of Imatinib and Sorafenib
7. Factors Affecting Interindividual Variability of Transporter Function and Expression in Humans
7-1.Role of Genetic Transporter Variants in TKI Pharmacokinetics and Response in Humans
7-2.Role of Transporter Regulation for TKI Resistance
8. Concluding Remarks and Future Directions
보고서작성신청
최근 미 식약청에서 25개의 타이로신 카이나제 억제제(TKIs)가 승인되었고 약 130개 이상이 임상시험 중에 있을 정도로 이 TKI들은 여러 종류의 암 또는 질병들의 치료제로 개발하여 적용 중에 있는데, 많은 증거들은 이 TKIs가 약물 저항 등에 관여한다는 것을 보여주고 있다. 본 분석물은 TKI 특성 및 약물 효과에 관여하는 하는 TKIs에서 세포막 수송체의 basic과 임상 약물학 등의 최근 지식을 제공해준다.