Direct Neuronal Reprogramming: Achievements, Hurdles, and New Roads to Success
2018-01-09
org.kosen.entty.User@5eb0b46d
김형택(khtgood)
분야
뇌과학
개최일
6 July 2017
신청자
김형택(khtgood)
개최장소
URL
행사&학회소개
1. Introduction
2. The Starter Cell: Cell-Type-Speci？c Prerequisites and Neuronal Subtype Generation
3. Hurdles in Direct Reprogramming: From Common Mechanisms to Cell-Type Speci？city
4. Repressive Barriers Common to iPSC Generation and Direct Neuronal Conversion
5. Proliferation, Chromatin Status, and Chromatin Remodeling: Similarities and Differences in Neuronal and iPSC Reprogramming
6. Cell Fate Gatekeepers and Terminal Selector Genes: From Common to Speci？c Guardians of Cell Identity
7. Cell-Type-Speci？c Barriers: Non-neuronal and Neuron-Speci？c Programs Guarded by REST and Myt1
8. Metabolic Changes and Cell Fate Decision
9. Metabolic Changes in Neuronal Differentiation and Direct Neuronal Reprogramming: Comparison to iPSC Reprogramming
10. Intrinsic Regulators: Metabolic Genes as Direct Targets of Neuronal Transcription Factors
11. Extrinsic Regulators: Effect of Oxygen Tension and ROS Production in Neuronal Reprogramming
12. In Vivo Neuronal Reprogramming: The Challenges and Opportunities
13.Macroglia and Reactive Gliosis as an Entry Point for Direct Neuronal Reprogramming
14. The Brain Injury Environment: Opportunities and Challenges for Direct Neuronal Reprogramming
15. Induction of Neuronal Subtypes In Vivo
2. The Starter Cell: Cell-Type-Speci？c Prerequisites and Neuronal Subtype Generation
3. Hurdles in Direct Reprogramming: From Common Mechanisms to Cell-Type Speci？city
4. Repressive Barriers Common to iPSC Generation and Direct Neuronal Conversion
5. Proliferation, Chromatin Status, and Chromatin Remodeling: Similarities and Differences in Neuronal and iPSC Reprogramming
6. Cell Fate Gatekeepers and Terminal Selector Genes: From Common to Speci？c Guardians of Cell Identity
7. Cell-Type-Speci？c Barriers: Non-neuronal and Neuron-Speci？c Programs Guarded by REST and Myt1
8. Metabolic Changes and Cell Fate Decision
9. Metabolic Changes in Neuronal Differentiation and Direct Neuronal Reprogramming: Comparison to iPSC Reprogramming
10. Intrinsic Regulators: Metabolic Genes as Direct Targets of Neuronal Transcription Factors
11. Extrinsic Regulators: Effect of Oxygen Tension and ROS Production in Neuronal Reprogramming
12. In Vivo Neuronal Reprogramming: The Challenges and Opportunities
13.Macroglia and Reactive Gliosis as an Entry Point for Direct Neuronal Reprogramming
14. The Brain Injury Environment: Opportunities and Challenges for Direct Neuronal Reprogramming
15. Induction of Neuronal Subtypes In Vivo
보고서작성신청
전분화능줄기세포읜 단점을 극복하고자 하나의 대안으로 교차분화법이 주목을 받고 있다. 최근 신경 세포로의 교차분화에 대한 메카니즘과 생체 내에서 높은 효율의 교차분화에 대한 연구 발표로 기존에 문제시 되었던 장애물을 극복하는 새로운 통찰력을 얻게 되었다. 이번 보고서에서는 교차분화 과정에서 중점으로 다루고 있는주요한 내용과 영향을 주는 요소에 대해 기술하고, 특히, 신경계 세포 교차분화에 대한 내용을 중점으로 다루고자 한다.