KOSEN 한인과학기술자네트워크

Muscle Biology, Exercise Physiology and Sports Medicine Primary Sponsor: Department of Health and Human Services Deadline: 4/1/2001; 8/1/2001; 12/1/2001 KEYWORDS D. Muscle Biology Branch. Supports research on skeletal muscle, its diseases and disorders, and its central role in human physiology and exercise. Topics include the molecular structure of muscle and the molecular mechanisms that produce force and motion. An aim is understanding the alterations in muscle resulting from increased exercise regimens and, conversely, the atrophy that follows immobilization during injury or illness. Some of the specific areas of research covered by the Muscle Biology Branch include Muscle Physiology, Molecular Architecture, Muscle Membranes, Muscle Development and Specialization, Musculoskeletal Fitness and Adaptive Biology, Muscle Diseases, and Sports Medicine, Muscle Injury and Muscle Repair. Areas that may be of interest to small businesses include but are not limited to: A. Muscle Structure and Function 1. Development of methods and materials directed toward the solution of muscle cytoskeletal and membrane protein structures by x-ray diffraction, electron diffraction, and NMR spectroscopy. 2. New methods for the purification and reconstitution of muscle membrane proteins. 3. Development of monoclonal and/or recombinant antibodies to cytoskeletal and membrane proteins exhibiting high specificity and affinity and broad cross-species reactivity. B. Muscle Fitness and Sports Medicine 1. Improve measurement of muscle strength and balance, including refined instrumentation for biomechanical assessment of normal movement and posture. 2. Develop quantitative methods of assessing postural perturbations and forces relevant to activities of daily living. 3. Improve imaging and analytical techniques to measure skeletal muscle properties, (e.g., through MRI Imaging and Spectroscopy). 4. Imaging techniques which allow simultaneous imaging of muscle morphology and metabolism and blood flow. 5. Development of novel assays or modifications of currently existing assay of muscle metabolism for use with human biopsy samples. 6. Develop biosensors to detect changes in pressure, temperature, or physiological parameters associated with muscular activity. 7. Development of treatments for wound healing and improve general understanding of the natural healing process for muscle. 8. Develop antioxidant interventions to prevent oxidative damage during muscle use and overuse. 9. Develop cell culture models for rapid testing of treatments for muscle injury and wasting. C. Development and Genetic Diseases 1. Develop animal models that mimic the pathophysiology of the genetic human muscle diseases. 2. Develop gene vectors (viral and non - viral), promoter and enhancer elements and related methodologies that could be used for in vivo and ex vivo gene therapy for muscular diseases. 3. Develop cell lines and tissue cultures for replacement of muscle that has been damaged or destroyed. 4. Develop markers for muscle satellite cells and use them to characterize availability for muscle repair. 5. Develop techniques, equipment, and software to enable improved imaging of muscle development and specialization. Other Research Topic(s) Within Mission of Institute Rheumatic Diseases Dr. Susana Serrate-Sztein National Institute of Arthritis and Musculoskeletal and Skin Diseases 301) 594-5032; Fax: (301) 480-4543 Email: ss86e@nih.gov Cartilage and Connective Tissue Dr. Bernadette Tyree National Institute of Arthritis and Musculoskeletal and Skin Diseases (301) 594-5032; Fax: (301) 480-4543 Email: bt16w@nih.gov Muscle Biology Dr. Richard Lymn National Institute of Arthritis and Musculoskeletal and Skin Diseases (301) 594-5128; Fax: (301) 480-4543 Email: rl28b@nih.gov Skin Diseases Dr. Alan N. Moshell National Institute of Arthritis and Musculoskeletal and Skin Diseases (301) 594-5017; Fax: (301) 480-4543 Email: am40j@nih.gov Orthopaedics Dr. James Panagis National Institute of Arthritis and Musculoskeletal and Skin Diseases (301) 594-5055; Fax: (301) 480-4543 Email: jp149d@nih.gov Bone Biology Dr. William Sharrock National Institute of Arthritis and Musculoskeletal and Skin Diseases (301) 594-5055; Fax: (301) 480-4543 Email: ws19h@nih.gov Bone Diseases Dr. Joan McGowan National Institute of Arthritis and Musculoskeletal and Skin Diseases (301) 594-5055; Fax: (301) 480-4543 Email: jm106v@nih.gov For administrative and business management questions, contact: Ms. Florence Turska National Institute of Arthritis and Musculoskeletal and Skin Diseases (301) 594-3507; Fax: (301) 480-5450 Email: ft7p@nih.gov NOTE: The Solicitations listed on this site are partial copies from the various SBIR agency solicitations and are not necessarily the latest and most up-to-date. For this reason, you should always use the suggested links on our reference pages. These will take you directly to the appropriate agency information where you can read the official version of the solicitation you are interested in. The official link for this page is: http://grants.nih.gov/grants/funding/sbir.htm. Solicitation closing dates are: April 1, August 1, and December 1, 2001.