KOSEN 한인과학기술자네트워크

Biomaterials, Biomimetics, and Tissue Engineering Primary Sponsor: Department of Health and Human Services Deadline: 4/1/2001; 8/1/2001; 12/1/2001 KEYWORDS Biomaterials, Biomimetics, and Tissue Engineering Emphasis is on the development of natural and synthetic materials to be used for the repair, regeneration, restoration and reconstruction of oral tissues and organs; on the development and improvement of evaluation and measurement systems for the characterization of implanted material properties; on their interactions as well as on their performance under the severity of the biological environment; and finally on the development and/or improvement of new alloy combinations, especially those that are mercury free. A. Develop strategies for site-specific focus of repair and regeneration dynamics (e.g., smart implants to specifically attach the appropriate reparative cells). B. Establish libraries of structural recognition epitopes (peptides, carbohydrates) to screen biological activities (e.g., bacterial adherence to soft and hard oral tissues). C. Develop non-destructive methods for the characterization of material properties in vivo and in vitro. D. Develop synthetic analogues of oral/craniofacial tissues and organs. E. Develop more sensitive methods to determine and measure the interactions of materials with biological systems (e.g., material biocompatibility and bioactivity in the oral environment). F. Optimize imaging techniques for describing the architecture of oral tissues and structures. G. Develop computer and mathematical modeling systems capable of mimicking biological tissues and of evaluating material designs. H. Develop novel techniques for ensuring sterility of biomimetic structures prior to implantation. I. Develop delivery systems that are compatible with host immunity; consider hybrids and artificial vectors as well as viral and non-viral gene delivery systems with cell-type selectivity. J. Develop in vitro methods that predict immunogenicity to vectors used for gene transfer as well as for biomaterials. K. Develop improved materials, designs (nanotechnology principles) and surgical techniques for artificial implants to support replacement of dental, oral and craniofacial tissues and organs. L. Develop new and improved instruments and techniques for the diagnosis and treatment of TMDs. M. Develop improved composite materials and adhesive sealants suitable for restoring crowns of posterior teeth and exposed roots of teeth. N. Develop new non-mercury containing filling materials. For additional information on research topics, contact: Program Staff Dr. Bernard W. Janicki National Institute of Dental and Craniofacial Research Building 45, Room 4AN-12B 45 Center Drive, MSC 6402 Bethesda, MD 20892-6402 (301) 594-2088; Fax: (301) 480-8318 Email: Bernard.Janicki@nih.gov For administrative and business management questions, contact: Mr. Martin Rubinstein National Institute of Dental and Craniofacial Research 45 Center Drive, MSC 6402 Building 45, Room 4AN-44A Bethesda, MD 20892-6402 (301) 594-4800; Fax: (301) 480-8301 Email: mr49c@nih.gov Data Coordinator Ms. Mary Ann Williamson National Institute of Dental and Craniofacial Research 45 Center Drive, MSC 6402 Building 45, Room 5AN-38 Bethesda, MD 20892-6402 (301) 594-3617; Fax: (301) 480-3648 NOTE: The Solicitations listed on this site are partial copies from the various SBIR agency solicitations and are not necessarily the latest and most up-to-date. For this reason, you should always use the suggested links on our reference pages. These will take you directly to the appropriate agency information where you can read the official version of the solicitation you are interested in. The official link for this page is: http://grants.nih.gov/grants/funding/sbir.htm. Solicitation closing dates are: April 1, August 1, and December 1, 2001.