KOSEN 한인과학기술자네트워크

Chronic Disabling Diseases Primary Sponsor: Department of Health and Human Services Deadline: 4/1/2001; 8/1/2001; 12/1/2001 KEYWORDS Chronic Disabling Diseases Emphasis on research on chronic disabling diseases, including injury, of the oral-cranio facial-dental areas including neuropathies and neurodegenerative disorders, osteoporosis and other diseases of bone and connective tissue, diseases of the temporomandibular joint, autoimmune diseases (e.g., Sjogren’s syndrome) which influence and which are influenced by diseases of the oral cavity, and reciprocal influences of other systemic diseases such as diabetes and cardiovascular diseases and the oral cavity. A. Develop improved measures for measuring chemosensory, tactile, kinesthetic, or proprioceptive function involving craniofacial structures. Such measures may be useful in screening for deficits, improving diagnosis, or for evaluating response to dental treatments or interventions. B. Develop improved measures for assessing oral-motor coordination or oral behaviors (e.g., swallowing, masticatory efficiency). Such measures will facilitate screening for deficits in special populations, improving diagnosis, or evaluating response to dental treatments or interventions. C. Develop improved biomarkers or treatments for neuropathic conditions or neurodegenerative conditions affecting oral-craniofacial tissues or structures. D. Develop assays facilitating reliable evaluations of relationships between hormonal or chronobiological variations and other risk factors, as these relate to onset or exacerbation of pain symptoms. E. Develop improved in vitro or animal models for evaluating biomechanical, wear, functional or systemic responses associated with TMJ devices or engineered tissues. F. Develop improved in vitro or animal models for assessing pathobiological changes in the TMJ or masticatory muscles; improved biochemical markers of joint degradation. Such studies could have eventual relevance to improving diagnosis or treatment in humans. G. Develop innovative approaches to reduce foreign body reactions or to improve surgical outcomes for prosthetic devices or bone grafts received subsequent to failed alloplastic TMJ implants. H. Develop safe and effective biomaterials or procedures useful in repairing the temporomandibular joint (TMJ) following trauma, degenerative or inflammatory diseases processes, or iatrogenically-induced pathology (e.g., failed TMJ implants). I. Develop diagnostic reagents and tests necessary to effectively use changes in saliva to diagnose and monitor specific disease processes, drug therapy, genetic defects, nutritional status, and age-specific therapy. J. Develop and characterize immortalized normal human and rodent salivary gland epithelial cell lines with appropriate phenotypic expression. K. Develop artificial saliva and/or drugs (sialogogues) for the treatment of xerostomia and develop controlled release delivery systems for their delivery at desired sites. L. Develop non-invasive methods for the determination of the efficacy and safety of artificial saliva, sialogogues and of their delivery vehicles. M. Develop viral and non-viral vectors for salivary gene therapy and gene therapeutics. N. Develop recombinant proteins and synthetic-peptides of salivary molecules with known activities as well as vehicles for their delivery. O. Evaluate the adverse effects of oral microbes on systemic diseases and conditions (e.g., diabetes, cardiovascular diseases), and develop intervention strategies to alleviate these effects. P. Develop apparatus for craniofacial bone distraction that is contained entirely within the oral cavity. Q. Develop more efficient methods, materials, and devices for prevention of injuries to the teeth, mouth, and face during athletic activities. R. Develop more efficient methods, materials, and appliances for orthodontic tooth movement. S. Develop improved appliances to aid suckling by newborn infants with cleft palate and cleft lip. For additional information on research topics, contact: Program Staff Dr. Bernard W. Janicki National Institute of Dental and Craniofacial Research Building 45, Room 4AN-12B 45 Center Drive, MSC 6402 Bethesda, MD 20892-6402 (301) 594-2088; Fax: (301) 480-8318 Email: Bernard.Janicki@nih.gov For administrative and business management questions, contact: Mr. Martin Rubinstein National Institute of Dental and Craniofacial Research 45 Center Drive, MSC 6402 Building 45, Room 4AN-44A Bethesda, MD 20892-6402 (301) 594-4800; Fax: (301) 480-8301 Email: mr49c@nih.gov Data Coordinator Ms. Mary Ann Williamson National Institute of Dental and Craniofacial Research 45 Center Drive, MSC 6402 Building 45, Room 5AN-38 Bethesda, MD 20892-6402 (301) 594-3617; Fax: (301) 480-3648 NOTE: The Solicitations listed on this site are partial copies from the various SBIR agency solicitations and are not necessarily the latest and most up-to-date. For this reason, you should always use the suggested links on our reference pages. These will take you directly to the appropriate agency information where you can read the official version of the solicitation you are interested in. The official link for this page is: http://grants.nih.gov/grants/funding/sbir.htm. Solicitation closing dates are: April 1, August 1, and December 1, 2001.