KOSEN 한인과학기술자네트워크

Inherited Diseases and Disorders Primary Sponsor: Department of Health and Human Services Deadline: 4/1/2001; 8/1/2001; 12/1/2001 KEYWORDS The NIDR conducts and fosters research on the etiology, pathogenesis, prevention, diagnosis, and treatment of oral, craniofacial and dental diseases and conditions. For more specific information about areas of interest to the NIDR, please visit our home page at http://www.nidcr.nih.gov Inherited Diseases and Disorders Emphasis is on etiology, prevention, and treatment of craniofacial anomalies such as cleft lip and palate, hemifacial microsomia, malocclusion, and syndromic and non-syndromic disorders that manifest craniofacial defects. This includes inherited and sporadic birth defects as well as acquired disfigurement and their effects on functions of the craniofacial region. A. Develop and operate registries to track craniofacial birth defects, diagnosis techniques, treatment protocols, and outcome assessments. B. Develop and operate tissue banks and/or DNA libraries of samples from patients with craniofacial birth defects and from unaffected relatives to aid in prospective and retrospective epidemiology and linkage studies to facilitate the discovery of genes involved in craniofacial dysmorphologies. C. Production of genetic and immunological markers specific for developing craniofacial tissues (e.g., stage specific markers for discreet populations of premigratory, migratory, and differentiating neural crest cells). D. Develop early pregnancy genetic tests to screen fetal cells in maternal blood for genetic mutations involved in inherited syndrome and non-syndrome craniofacial defects. E. Develop more efficient methods, materials, and appliances for orthodontic tooth movement. F. Develop instrumentation to improve the diagnosis and treatment of inherited and acquired craniofacial defects. G. Develop instrumentation and methods to more accurately measure craniofacial growth in order to assess normal growth patterns as well as the effects of treatment procedures. H. Develop animal models possessing specific genetic craniofacial anomalies for use in studies on the etiology of disease, gene regulation, gene/environment analysis, and gene-product function and development of treatment protocols. I. Develop improved appliances to aid suckling by newborn infants with cleft palate and cleft lip. For additional information on research topics, contact: Program Staff Dr. Bernard W. Janicki National Institute of Dental and Craniofacial Research Building 45, Room 4AN-12B 45 Center Drive, MSC 6402 Bethesda, MD 20892-6402 (301) 594-2088; Fax: (301) 480-8318 Email: Bernard.Janicki@nih.gov For administrative and business management questions, contact: Mr. Martin Rubinstein National Institute of Dental and Craniofacial Research 45 Center Drive, MSC 6402 Building 45, Room 4AN-44A Bethesda, MD 20892-6402 (301) 594-4800; Fax: (301) 480-8301 Email: mr49c@nih.gov Data Coordinator Ms. Mary Ann Williamson National Institute of Dental and Craniofacial Research 45 Center Drive, MSC 6402 Building 45, Room 5AN-38 Bethesda, MD 20892-6402 (301) 594-3617; Fax: (301) 480-3648 NOTE: The Solicitations listed on this site are partial copies from the various SBIR agency solicitations and are not necessarily the latest and most up-to-date. For this reason, you should always use the suggested links on our reference pages. These will take you directly to the appropriate agency information where you can read the official version of the solicitation you are interested in. The official link for this page is: http://grants.nih.gov/grants/funding/sbir.htm. Solicitation closing dates are: April 1, August 1, and December 1, 2001.