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DNA-mediated artificial nanobiostructures: state of the art and future

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R. BASHIR

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DNA (deoxyribonucleic acid)-mediated assembly of nanometer and micrometer scale structures can have a profound impact in the fields of nanoelectronics and nanotechnol-ogy. Such structures can also find applications in microelectromechanical systems, hybrid bio-sensors, and the potential to continue the scaling of Moore’s law beyond the 50 nm node. While engineers and scientists have been long aspiring to controllably and specif-ically manipulate structures at the micrometer and nanometer scale, nature has been per-forming these tasks and assembling structures with great accuracy and high efficiency us-ing highly specific biological molecules such as DNA and proteins. This paper describes the motivations and fundamentals behind these assembly concepts, with a focus on DNA hybridization-mediated assembly, and presents the state of the art in this field. In addition, new ideas and directions for future research on DNA-mediated assembly of active devices and DNA-based molecular devices are also presented. 1. Motivation for bio-inspired self-assembly 2. DNA fundamentals 3. Attachment of DNA to gold surfaces 4. DNA-inspired self-assembly and construction of nanostructures 5. Future directions 6. Conclusions References
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