2017-08-18
org.kosen.entty.User@8923361
박영환(yehapark)
분야
나노화학,융합화학
발행기관
Arun Richard Chandrasekaran 외
발행일
4 April 2016
URL
DNA를 기반으로 한 바이오 센서에 관한 내용이다. 핵산 나노구조물을 이용하여 삶의 질 향상을 위한 다양한 진단에 이용하고자 하는 노력이 지속되고 있다. 본 자료를 통해 최근의 연구 성과를 살펴볼 수 있을 것이다.
The nanoscale features of DNA have made it a useful molecule for bottom-up construction of nanomaterials, for example, two- and three-dimensional lattices, nanomachines, and nanodevices. One of the emerging applications of such DNA-based nanostructures is in chemical and biological sensing, where they have proven to be cost-effective, sensitive and have shown promise as point-of-care diagnostic tools. DNA is an ideal molecule for sensing not only because of its specificity but also because it is robust and can function under a broad range of biologically relevant temperatures and conditions. DNA nanostructure-based sensors provide biocompatibility and highly specific detection based on the molecular recognition properties of DNA. They can be used for the detection of single nucleotide polymorphism and to sense pH both in solution and in cells. They have also been used to detect clinically relevant tumor biomarkers. In this review, recent advances in DNA-based biosensors for pH, nucleic acids, tumor biomarkers and cancer cell detection are introduced. Some challenges that lie ahead for such biosensors to effectively compete with established technologies are also discussed.
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