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Is taxol a perfect drug?

2000-09-28 org.kosen.entty.User@407d78bb @@@sunny(@@@sunny)
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I know some of anticancer drugs can be used together as a combination therapy. Is taxol combined with other drugs? Is there a development of resistance? If so, what is the mechanism behind?
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    김수기님의 답변

    2000-09-28
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    >I know some of anticancer drugs can be used together as a combination therapy. >Is taxol combined with other drugs? >Is there a development of resistance? >If so, what is the mechanism behind? > ans) No perfect drug on earth. please see my reference file. It's not complete answer. Briefly, if I explain it, taxol is best combined with platinum drug(carboplatin) and other cytotoxic drug, monoclonal antibodies etc could be synergistic with taxol on preclinical level. Taxol has a absolute resistance obstacle as like other anticancer drugs. However, mechanism of taxol resitance was different from that of existent anticancer drug(for example, MDR pump). Want more Q, please email to me. sooki
    답변수정
    >I know some of anticancer drugs can be used together as a combination therapy. >Is taxol combined with other drugs? >Is there a development of resistance? >If so, what is the mechanism behind? > ans) No perfect drug on earth. please see my reference file. It's not complete answer. Briefly, if I explain it, taxol is best combined with platinum drug(carboplatin) and other cytotoxic drug, monoclonal antibodies etc could be synergistic with taxol on preclinical level. Taxol has a absolute resistance obstacle as like other anticancer drugs. However, mechanism of taxol resitance was different from that of existent anticancer drug(for example, MDR pump). Want more Q, please email to me. sooki
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    장성훈님의 답변

    2000-09-29
    • 0
    >I know some of anticancer drugs can be used together as a combination therapy. >Is taxol combined with other drugs? >Is there a development of resistance? >If so, what is the mechanism behind? > Taxol is usually combined with carboplatin. Several known mechanism of resistance is mrdi Pgp overexpression (drug efflux pump) and the changes in tubulin which is a mojor binding site of taxol. In addition, mutations of several apoptosis-relating gene are known as a reistance mechanism. For more detail, send me e-mail, I will do my best to help you. Thanks.
    답변수정
    >I know some of anticancer drugs can be used together as a combination therapy. >Is taxol combined with other drugs? >Is there a development of resistance? >If so, what is the mechanism behind? > Taxol is usually combined with carboplatin. Several known mechanism of resistance is mrdi Pgp overexpression (drug efflux pump) and the changes in tubulin which is a mojor binding site of taxol. In addition, mutations of several apoptosis-relating gene are known as a reistance mechanism. For more detail, send me e-mail, I will do my best to help you. Thanks.
    등록된 댓글이 없습니다.
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