KOSEN 한인과학기술자네트워크

아래의 자료들은 산업기술정보원(http://www.kiniti.re.kr)을 통해 검색된 자료들입니다. 필요한 자료는 산업기술정보원 웹을 통해 원문신청이 가능합니다. * 미생물과 초식 생물에 대한 화학적 방어를 일으키게 하는 berberine, palmatine 및 sanguinarine 의 생화학적 활성, Schmeller,T.; Br ning,B.; Wink,M.;, Phytochemistry (USA) 44(2); P257-266; 1997 * Sanguinarine(Pseudochelerythrine) 은 NF- κ B 활성화 , I κ B α 인산화 및 분해의 잠재적 저해자이다, Chaturvedi,M.M.; Kumar,A.; Darnay,B. G.;, The Journal of biological chemistry (USA) 272(48); P30129-30134; 1997 * Production of sanguinarine by multiple shoot culture of macleaya cordata, 김경화, 포항: 포항공대 대학원, 199602 * Papaver somniferum 세포 배양에 의한 sanguinarine 生産에 미치는 폴리머 吸着劑의 영향, Williams, R.D., Biotechnology and bioengineering (USA) 40(8); P971-977; 1992 아래는 산업기술정보원 영문DB를 통해 검색된 자료입니다. 1 COM1996373254016 Production of sanguinarine by elicited plant cell culture III. Immobilized bioreactor cultures 199637 2 COM1996373254015 Production of sanguinarine by elicited plant cell culture II. Further nutritional aspects 199637 3 COM1996373254014 Production of sanguinarine by elicited plant cell culture I. Shake flask suspension cultures 199637 4 COM1993050754166 Production of sanguinarine by suspension culture of Papaver somniferum in bioreactors 199305 5 COM1992120586178 Elicitation of sanguinarine production in two-phase cultures of Eschscholtzia californica 199212 >Sanguinarine에 관해 알고싶습니다.(물성과 추출에 대한 자세한것)

Following articles contain information on the properties and practical applications of sanguinarine. 1: Photochem Photobiol 1992 Sep;56(3):311-7 Published erratum appears in Photochem Photobiol 1996 Oct;64(4):736 Photophysical property of sanguinarine in the excited singlet state. Das A, Nandi R, Maiti M Biophysical Chemistry Laboratory, Indian Institute of Chemical Biology, Calcutta. The photophysical property of the alkanolamine form of sanguinarine has been studied in aqueous and organic medium under various environmental conditions from the measurement of absorption, fluorescence and NMR spectroscopy. Alkanolamine fluorescence shows an excitation time dependent fluorescence quenching and the rate of quenching increases significantly with increasing pH and concentration of the species, while it decreases with increasing temperature. This phenomenon is explained by excited state intramolecular proton transfer from a 6-OH group to the lone pair of nitrogen through the formation of zwitterion. 2: Br Dent J 1995 Apr 8;178(7):254-8 The use of sanguinarine in mouthwashes and toothpaste compared with some other antimicrobial agents. Grenby TH Department of Oral Medicine & Pathology, United Medical & Dental Schools, Guy's Hospital, London. Dental practitioners say that they get information to answer patients' queries on mouthwashes chiefly from their studies in periodontology and from articles in the British Dental Journal. Most practitioners who were asked about this knew of the benefits of Corsodyl (chlorhexidine) and fluoride-containing rinses, but few were aware of the active ingredients and effectiveness of the wide range of mouthwashes now on the market. The majority said they would welcome more information on this. This review was undertaken because there was a move to introduce mouthwashes containing sanguinarine into the UK. Part of its appeal would be that it is a natural therapeutic product, as distinct from a 'synthetic' or 'artificial' chemical. Information collected from scientific publications on sanguinarine, which has been in use in the USA and on the Continent in mouthwashes and toothpastes, is presented here. The consensus is that (a) it has some assets in curbing supragingival plaque, although it is uncertain whether the presence of zinc salts assists this, and (b) it is more effective in a mouthwash than in a toothpaste. It appears to be less effective than chlorhexidine, but no direct comparisons with triclosan preparations have been discovered. Like other mouthwashes, it does not affect subgingival plaque. 3: Acta Univ Palacki Olomuc Fac Med 1995;139:7-16 Benzo[c]phenanthridine alkaloids sanguinarine and chelerythrine: biological activities and dental care applications. Walterova D, Ulrichova J, Valka I, Vicar J, Vavreckova C, Taborska E, Harjrader RJ, Meyer DL, Cerna H, Simanek V Institute of Medical Chemistry, Faculty of Medicine, Palacky University Olomouc, Czech Republic. This article reviews chemical, pharmacological, and toxicological research relating to two principal benzo[c]phenanthridine alkaloids, namely sanguinarine and chelerythrine, in the period 1980-1994. The medical applications of these alkaloids in relation to their biological activities are discussed. 4: Clin Prev Dent 1990 Aug-Sep;12(3):18-25 Sanguinarine: comparisons of antiplaque/antigingivitis reports. Balanyk TE A critical comparison of the numerous clinical studies on sanguinarine indicates an extreme divergence of reported effects on plaque/gingivitis, ranging from significant reductions to findings of no detectable effect. These equivocal findings stem from numerous short-term studies and fewer long-term studies employing divergent experimental methods. The long-term performance of the sanguinarine mouthrinse or dentifrice, alone or in combined use, still remains to be firmly demonstrated and replicated. The majority of clinical trials fail to demonstrate consistent clinical benefits from the use of this agent. 5: J Clin Dent 1989 Spring;1(4):96-101 Antimicrobial action of sanguinarine. Godowski KC Sanguinarine is a benzophenanthridine alkaloid derived from rhizomes of Sanguinaria canadensis L. (bloodroot). It is a cationic molecule which converts from an iminium ion form at pH less than 6 to an alkanolamine form at pH greater than 7. Sanguinaria extract is composed of sanguinarine and five other closely related alkaloids. The safety profile of both sanguinarine and sanguinaria extract provide a broad margin for their safe use in oral health products. Sanguinarine has broad antimicrobial activity as well as antiinflammatory properties. In vitro studies indicate that the anti-plaque action of sanguinaria is due to its ability to inhibit bacterial adherence to newly formed pellicle, its retention in plaque being 10-100 times its saliva concentration, and due to its antimicrobic properties. The MIC of sanguinarine ranges from 1 to 32 micrograms/mL for most species of plaque bacteria. Long term use of sanguinaria-containing toothpaste and oral rinse products does not predispose users to detrimental shifts in oral flora. Electron microscopic studies of bacteria exposed to sanguinarine demonstrate that bacteria aggregate and become morphologically irregular. Sanguinarine-containing slow release polymer systems are currently being developed for use in periodontitis treatment applications.