KOSEN 한인과학기술자네트워크

두 제제의 가장 큰 차이는 amphotericin B는 polyene 계통의 약이고, itraconazole은 azole계통의 약이라는 것입니다. amphotericin B는 1950년대에 itraconzole은 1990년 초에 도입된 약입니다. 첨부해 드리는 파일에는 Datamonitor 자료 중 polyene류와 azole류에 관해 간단히 요약한 것과 각 약에 대한 간단한 설명이 들어 있습니다. 참고하시기 바랍니다. 아래는 참고할 만한 문헌입니다. Source :Clin Infect Dis. 1998 May;26(5):1107-10. Titel :Amphotericin B and itraconazole for treatment of disseminated Penicillium marneffei infection in human immunodeficiency virus-infected patients. Sirisanthana T, Supparatpinyo K, Perriens J, Nelson KE. Department of Medicine, Faculty of Medicine, Chiang Mai University, Thailand. ------------------------------------- Source : Antimicrob Agents Chemother. 2003 Feb;47(2):813-5. Title : Efficacy of amphotericin B or itraconazole in a murine model of central nervous system Aspergillus infection Chiller TM, Sobel RA, Luque JC, Clemons KV, Stevens DA. Division of Infectious Diseases, Department of Medicine, Santa Clara Valley Medical Center, San Jose, California 95128-2699, USA. -------------------------------------- http://www.annals.org/cgi/content/abstract/135/6/412 Source : Annals of Internal Medicine /18 September 2001 | Volume 135 Issue 6 | Pages 412-422 Title : Intravenous and Oral Itraconazole versus Intravenous Amphotericin B Deoxycholate as Empirical Antifungal Therapy for Persistent Fever in Neutropenic Patients with Cancer Who Are Receiving Broad-Spectrum Antibacterial Therapy A Randomized, Controlled Trial Marc Boogaerts, MD, PhD; Drew J. Winston, MD; Eric J. Bow, MD; Gary Garber, MD; Annette C. Reboli, MD; Anthony P. Schwarer, MD, FRACP; Nicolas Novitzky, MD, PhD; Angelika Boehme, MD; Elisabeth Chwetzoff, MD; and Karel De Beule, RPh, the Itraconazole Neutropenia Study Group* >약리학이나 임상하시는 분중에 다음 제제의 차이점에 관한 자료 있으시면 알려주세요

원하시는 해답은 아니지만 혹시나 참고가 되실까 싶어 첨부파일로 올립니다. 조금이나마 도움이 되었으면 좋겠네요... 아래내용은 Harrison에 나오는 서론 부분을 발췌한 것입니다. Imidazoles and Triazoles These synthetic compounds act by inhibiting ergosterol synthesis in the fungal cell wall and, when given topically, may cause direct damage to the fungal cytoplasmic membrane. The imidazoles available for cutaneous application include clotrimazole, econazole, ketoconazole, sulconazole, oxiconazole, and miconazole. Vaginal formulations include four imidazoles (miconazole, clotrimazole, tioconazole, and butoconazole) and one triazole (terconazole). As yet, no substantial differences in the efficacy of or local intolerance to the various topical azoles have become apparent. All are effective in the treatment of cutaneous candidiasis, tinea (pityriasis) versicolor, and mild to moderately severe ringworm of the glabrous skin. Vaginal formulations are effective for vulvovaginal candidiasis. Clotrimazole is poorly absorbed from the gastrointestinal tract, but the oral troche is useful as a topical treatment for oral and esophageal candidiasis. Polyene Macrolide Antibiotics These broad-spectrum antifungal agents combine with sterol in the fungal cytoplasmic membrane, increasing membrane permeability. Topically, they are not active against ringworm but are effective against candidiasis of the skin and mucous membranes. Nystatin and amphotericin B suspensions are effective in oral thrush, and vaginal troches are effective in vulvovaginal candidiasis. Both nystatin and amphotericin B are available in topical preparations for cutaneous candidiasis.