KOSEN 한인과학기술자네트워크

잘 아시겠지만, 혹시나 해서 다음의 사이트를 추천해 드리고 싶습니다. 저희 실험실에서 애용하는 사이트입니다. http://ctd.mdibl.org/ 싸이트에 접속하셔서, 상단 메뉴에서 Chemicals를 선택하시고, Terbinafine을 치셔서 surfing을 하시면 여러 유용한 자료를 얻을 수 있습니다. 특히 TOXLINE 을 click하시면 공식적인 많은 자료를 접속하실 수 있습니다. 무좀약 라미실 (미국 항진균제 비처방전 시장 1위)의 원료인 terbinafine은 생각보단 그리 많이 연구가 규명되지 않아 있군요. 저희 실험실에서도 terbinafine으로 세포내 target을 규명하는 연구를 수행하고 있습니다. >Terbinafine Hcl의 임상적 응용을 위해 기존에 평가되었던 독성평가자료(학회 또는 정부기관에서 공식적으로 인정된)를 구합니다. 여러분의 도움을 기다립니다.

>Terbinafine Hcl의 임상적 응용을 위해 기존에 평가되었던 독성평가자료(학회 또는 정부기관에서 공식적으로 인정된)를 구합니다. 여러분의 도움을 기다립니다. =========================================== http://www.fda.gov/cder/drug/advisory/sporanox-lamisil/default.htm 위 사이트에 가시면 Terbinafine HCl과 관련된 FDA의 리뷰관련 문서와 내용이 있습니다. 참고하시기 바랍니다. ================================================= CHEMICAL INDENTIFICATION Product Code SRP01197t Product Name TERBINAFINE HCl Synonyms LAMISIL COMPOSITION/INFORMATION ON INGREDIENTS C.A.S. No 78628-80-5 Molecular Formula C21H25N.HCl Formula Weight 291.45 Merck Index 9231 Product Group Antifungal HAZARDS IDENTIFICATION Not considered hazardous when handled under normal conditions with good house keeping. Label precautionary statements: S36/37 Wear suitable protective clothing and gloves. R20/21/22 Harmful by inhalation, in contact with skin and if swallowed. FIRST-AID MEASURES In case of inhalation: Remove to fresh air. If not breathing give artificial respiration. If breathing is difficult, give oxygen. Seek medical attention. In case of contact with skin: Immediately wash skin with soap and copious amounts of water for at least 15 minutes. If irritation persists, seek medical attention. In case of contact with eyes: Immediately flush eyes with copious amounts of water for at least 15 minutes. Seek medical advice. In case of ingestion: If swallowed, wash out mouth with water, provided person is concious. Seek medical advice. Remove and wash/dispose of contaminated clothing promptly. FIRE FIGHTING MEASURES Extinguishing Media: Carbon dioxide, dry chemical powder or appropriate foam. Water spray. Unusual fire and explosion hazards: Emits toxic fumes under fire conditions Special fire fighting procedures: Wear self-contained breathing apparatus and protective clothing to prevent contact with the skin and eyes. ACCIDENTAL RELEASE MEASURES Ensuring personal safety, mark out contaminated area with signs and prevent unauthorised access. Turn leaking containers up to prevent further Evaculate area. Wear self-contained breathing apparatus, rubber boots & heavy rubber gloves. Sweep-up/absorb in suitable material, place in a container and hold for disposal. Avoid raising dust. Ventilate area and wash spill site after pick-up complete. HANDLING AND STORAGE Store under the following conditions: Store cool, dark and dry. EXPOSURE CONTROL/PERSONAL PROTECTION Respiratory protection: required when dusts are generated. Eye protection: required. Hand protection: required. Industrial hygiene: Immediately change contaminated clothing. Wash hands and face after working with substance. PHYSICAL AND CHEMICAL PROPERTIES Appearance White powder Odour None Melting Point 195-198 Solubility Soluble in methanol, ethanol, methylene chloride. Slightly soluble in water STABILITY AND REACTIVITY Conditions to be avoided: Unknown Substances to be avoided: Unknown Hazardous decomposition products: Unknown TOXICOLOGICAL INFORMATION LD50 in mice: >4 g / kg orally; 393 mg / kg i.v. ECOLOGICAL INFORMATION Do not allow product to enter drinking water supplies, waste water or soil! DISPOSAL CONSIDERATIONS Dissolve or mix material with a suitable combustible solvent and incinerate in a chemical incinerator equipped with an afterburner and scrubber. Material should be disposed of in keeping with all local and national legislation. Packaging should be disposed of in keeping with all local and national legislation. Handle contaminated containers as product. TRANSPORT INFORMATION Classification: UN Number: REGULATORY INFORMATION OTHER INFORMATION While the information herein is believed to be reliable, it is furnished without warranty of any kind. It shall be used only as a guide. We assume no liabilities from the use of this product or information contained herein.

>Terbinafine Hcl의 임상적 응용을 위해 기존에 평가되었던 독성평가자료(학회 또는 정부기관에서 공식적으로 인정된)를 구합니다. 여러분의 도움을 기다립니다. 자료를 올립니다