KOSEN 한인과학기술자네트워크

종마다 조금씩 다르기 때문에 말씀드리기는 어렵구요... CpG islands는 유전자 앞에 위치하여 methylation 유무에 따라 그 유전자의 발현 on/off를 결정짓는 역할을 합니다. 따라서 새로운 서열에서 CpG island의 부분을 결정하고 찾아내는 것은 앞으로의 암연구에 매우 중요한 일이 될 것입니다. 현재 데이터를 분석해서 의미있는 영역의 CpG island를 찾기 위한 프로그램도 판매 중입니다... 아래의 사이트들이 Transcription start site를 예측해주는 검색 사이트들입니다..사이트에 들어가서 배열을 넣어주면 찾으실 수 있을 것입니다.. Transcription start site The basal promoter An Analogy Hormones exert many of their effects by forming transcription factors. Embryonic development requires the coordinated production and distribution of transcription factors. Enhancers ... http://users.rcn.com/jkimball.ma.ultranet/BiologyPages/P/Promoter.html Transcription start site Site within a gene where transcription of RNA begins. Terminator The site on a DNA sequence at which transcription and DNA replication stops. Cf. origin. http://hal.weihenstephan.de/genglos/asp/genreq.asp?nr=247 Transcription start site: The point in a DNA sequence at which transcription of a gene into RNA begins. Transcriptome: The complete set of RNAs transcribed from a genome. http://www.geocities.com/rgklink/glossary/molglos.html?200524 A regulatory region a short distance upstream from the 5' end of a transcription start site that acts as the binding site for RNA polymerase. A region of DNA to which RNA polymerase binds in order to initiate transcription. http://www.biochem.northwestern.edu/holmgren/Glossary/Definitions/Def-P/promoter.html Sequences on the 5' end of mRNA but not translated into protein. It extends from the transcription start site to just before the ATG translation initiation codon. 5' UTR may contain sequences that regulate translation efficiency or mRNA stability. http://www.changbioscience.com/res/res/r5ssUntranslatedsRegi.htm A sequence on DNA that functions as the RNA polymerase binding site, thus defining the transcription start site. http://www.sci.sdsu.edu/~smaloy/Glossary/P.html Regions of DNA rich in CpG dinucleotides, also known as CpG islands, are often found upstream of the transcription start site in both tissue specific and housekeeping genes. http://www.ornl.gov/sci/techresources/Human_Genome/publicat/97santa/informat.html They are ubiquitous and interact with the core promoter region surrounding the transcription start site(s) of all class II genes. http://www.biologydaily.com/biology/Transcription_factor A region of DNA extending 150-300 bp upstream from the transcription start site that contains binding sites for RNA polymerase and a number of proteins that regulate the rate of transcription of the adjacent gene. http://www.angelfire.com/nv/biology/dictionary.html >알고있는 genomic DNA의 Transcription site를 찾는 법을 알려주세요. CpG island에서의 Transcription site를 찾고 싶은데 어디가 해당 site인지 모르겠습니다. 제발 알려주세요. >감사합니다,