KOSEN 한인과학기술자네트워크

자료요청에 신청하시면.. 여러 분들이 구해 주실 것입니다.. 그리고 좀 더 정확히 적어 주셔야 찾기가 쉬울 것 갔습니다.. 해당 내용을 메드라인에서 검색하면 다음과 같습니다. 저널명하고.. 연고 및 호수 페이지 등을 정확히 적으셔야 합니다. J Cell Biol. 2006 Jan 2;172(1):115-25. Epub 2005 Dec 27. p53 functions as a negative regulator of osteoblastogenesis, osteoblast-dependent osteoclastogenesis, and bone remodeling. Wang X, Kua HY, Hu Y, Guo K, Zeng Q, Wu Q, Ng HH, Karsenty G, de Crombrugghe B, Yeh J, Li B. The Institute of Molecular and Cell Biology, Singapore 138673. p53 is a well known tumor suppressor. We show that p53 also regulates osteoblast differentiation, bone formation, and osteoblast-dependent osteoclast differentiation. Indeed, p53(-/-) mice display a high bone mass phenotype, and p53(-/-) osteoblasts show accelerated differentiation, secondary to an increase in expression of the osteoblast differentiation factor osterix, as a result. Reporter assays indicate that p53 represses osterix transcription by the minimal promoter in a DNA-binding-independent manner. In addition, p53(-/-) osteoblasts have an enhanced ability to favor osteoclast differentiation, in association with an increase in expression of macrophage-colony stimulating factor, which is under the control of osterix. Furthermore, inactivating p53 is sufficient to rescue the osteoblast differentiation defects observed in mice lacking c-Abl, a p53-interacting protein. Thus, these results identify p53 as a novel regulator of osteoblast differentiation, osteoblast-dependent osteoclastogenesis, and bone remodeling. >p53 functions as a negative regulator of osteoblastogenesis, osteoblast-dependent osteoclastogenesis, and bone remodeling > >Published online December 27, 2005. doi:10.1083/jcb.200507106 >© The Rockefeller University Press, 0021-9525 $8.00 >JCB, Volume 172, Number 1, 115-125 >please!!

>p53 functions as a negative regulator of osteoblastogenesis, osteoblast-dependent osteoclastogenesis, and bone remodeling > >Published online December 27, 2005. doi:10.1083/jcb.200507106 >？The Rockefeller University Press, 0021-9525 $8.00 >JCB, Volume 172, Number 1, 115-125 >please!!