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지식나눔

지식나눔

adipogenesis와 methylation사이의 관계에 대해 서술된 자료 있나요??

2006-07-25 org.kosen.entty.User@21523583 권오만(akan21)
  • 1
제가 요즘 공부하는 부분인데요... 이것에 대한 정보가 많이 없네요.. 혹시 알고 계신분 있으시면...꼭 좀 가르쳐 주세요...^^ 좋은 답변 기다리고 있겠습니다.. 그럼 수고하십시오~~~꾸벅...
  • adipogenesis
  • methylation
지식의 출발은 질문, 모든 지식의 완성은 답변! 
각 분야 한인연구자와 현업 전문가분들의 답변을 기다립니다.
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    김기홍님의 답변

    2006-08-08
    • 0
    The molecular basis of the role of methylation in adipogenesis is unclear. However, methylation-associated gene imprinting seems to be one of the determinants in gender-specific adipogenesis at least in animals. For example, a preadipocyte specfiic protein preadipocyte factor 1 (Pref-1) has been known to inhibit adipogenesis in both in vitro and in animals. Pref-1 knockout mice revealed that it not only accelerates adipogenesis but also exhibits growth retardation in mice(Moon YS, Mol Cell Biol. 2002 Aug;22(15):5585-92). Furthermore, this study clearly demonstrated that the physiological function of an imprinted gene pref-1 is indeed paternally inherited. >제가 요즘 공부하는 부분인데요... > >이것에 대한 정보가 많이 없네요.. > >혹시 알고 계신분 있으시면...꼭 좀 가르쳐 주세요...^^ > >좋은 답변 기다리고 있겠습니다.. > >그럼 수고하십시오~~~꾸벅...
    답변수정
    The molecular basis of the role of methylation in adipogenesis is unclear. However, methylation-associated gene imprinting seems to be one of the determinants in gender-specific adipogenesis at least in animals. For example, a preadipocyte specfiic protein preadipocyte factor 1 (Pref-1) has been known to inhibit adipogenesis in both in vitro and in animals. Pref-1 knockout mice revealed that it not only accelerates adipogenesis but also exhibits growth retardation in mice(Moon YS, Mol Cell Biol. 2002 Aug;22(15):5585-92). Furthermore, this study clearly demonstrated that the physiological function of an imprinted gene pref-1 is indeed paternally inherited. >제가 요즘 공부하는 부분인데요... > >이것에 대한 정보가 많이 없네요.. > >혹시 알고 계신분 있으시면...꼭 좀 가르쳐 주세요...^^ > >좋은 답변 기다리고 있겠습니다.. > >그럼 수고하십시오~~~꾸벅...
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