KOSEN 한인과학기술자네트워크

>궁금한게 있어서 이렇게 글을 올립니다. >다름이 아니라 platelet aggregation의 관련 paper을 찾고 있습니다. >pathway의 내용이 자세히 나와있는걸 찾는데 아직은 찾질 못해서 이렇게 글을 >올립니다. >또 하나는 platelet aggregation에 의한 질병이 있는지도 궁금합니다. >물론 paper이면 좋고요~~~좋은 싸이트를 알고 계세도 좋습니다., >많은 글 부탁 드립니다. >감사합니다. 참고하시고.. 좋은 실험되세요.. Mehta J, Mehta P, Burger C, Pepine CJ. Platelet aggregation studies in coronary artery disease. Past 4. Effect of aspirin. Atherosclerosis. 1978 Oct;31(2):169-75. PC Elwood, S Renaud, DS Sharp, AD Beswick, JR O'Brien and JW Yarnell. Ischemic heart disease and platelet aggregation. The Caerphilly Collaborative Heart Disease Study. 1991. Circulation, Vol 83, 38-44

>궁금한게 있어서 이렇게 글을 올립니다. >다름이 아니라 platelet aggregation의 관련 paper을 찾고 있습니다. >pathway의 내용이 자세히 나와있는걸 찾는데 아직은 찾질 못해서 이렇게 글을 >올립니다. >또 하나는 platelet aggregation에 의한 질병이 있는지도 궁금합니다. >물론 paper이면 좋고요~~~좋은 싸이트를 알고 계세도 좋습니다., >많은 글 부탁 드립니다. >감사합니다. There are a number of conditions or diseases that can cause platelet aggregation problems. These include: Von Willebrand disease. An inherited lack of a clotting factor called Von Willebrand factor. Platelet aggregation tests will show abnormal readings both with ristocetin and other aggregation stimulators. Bernard-Soulier syndrome. A rare and inherited platelet disorder. Platelet tests will not respond to ristocetin but will respond to other aggregation stimulators. Glanzmann’s thromboasthenia. A rare and inherited platelet disorder. When tested, platelets will respond to ristocetin but will fail to respond to other aggregation stimulators. Wiskott-Aldrich syndrome. A rare genetic disorder characterized by severely dysfunctional platelets and immunodeficiency. Platelets are unable to aggregate. Storage-pool disorders. A group of disorders that affects the size and shape of the platelets. Platelets will not aggregate in response to adenoside diphosphate, epinephrine or collagen. Polycythemia Vera. An abnormal increase in red blood cells caused by increased production in the bone marrow. Thrombotic thrombocytopenic purpura. A bleeding disorder in which platelets are destroyed by the patient’s own antibodies. Myeloproliferative disorders. Conditions related to leukemia in which there is an excess of bone marrow that results in an increase in circulating blood cells. Uremia. A toxic state in which excess urea and other chemical waste products accumulate in the blood as a result of kidney failure. The process through which this condition causes platelet disorders and excess bleeding is unknown. In addition, surgeries such as coronary artery bypass grafting and stenting can cause a temporary imbalance in platelet aggregation because of the medications (e.g., heparin) used to inhibit clotting during the procedure and the reaction of natural platelets that have come in contact with the inorganic surfaces of a cardiopulmonary bypass machine. Autoimmune disorders (e.g., AIDS) that produce antibodies against platelets and uremia due to kidney failure can also cause decreased platelet aggregation.