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지식나눔

지식나눔

howell jolly body와 소핵의 생성 메카니즘..

2007-01-08 org.kosen.entty.User@44ec2075 구은영(rosa0225)
  • 1
두가지의 생성 메카니즘이 궁금합니다. 어디에서 차이가 있는 것인지...
  • howell jolly body
  • micronuclei
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    유일재님의 답변

    2007-01-31
    • 0
    >두가지의 생성 메카니즘이 궁금합니다. >어디에서 차이가 있는 것인지... Identification of Howell-Jolly bodies (HJB) is accepted indicator of splenic dysfunction. HJB, also known as micronuclei in the toxicological sciences, are small ( 1 μm) erythrocyte DNA inclusions that are the consequence of cytogenetic damage, more specifically double-strand breaks or lagging whole chromosomes. Normally, HJB-containing erythrocytes are formed at a low frequency, and are removed quickly and efficiently from peripheral blood circulation by a healthy spleen; hence, their presence on the peripheral blood smear is indirect evidence of splenic dysfunction.
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    >두가지의 생성 메카니즘이 궁금합니다. >어디에서 차이가 있는 것인지... Identification of Howell-Jolly bodies (HJB) is accepted indicator of splenic dysfunction. HJB, also known as micronuclei in the toxicological sciences, are small ( 1 μm) erythrocyte DNA inclusions that are the consequence of cytogenetic damage, more specifically double-strand breaks or lagging whole chromosomes. Normally, HJB-containing erythrocytes are formed at a low frequency, and are removed quickly and efficiently from peripheral blood circulation by a healthy spleen; hence, their presence on the peripheral blood smear is indirect evidence of splenic dysfunction.
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