KOSEN 한인과학기술자네트워크

간단히 정리된 글을 올립니다. 생체내 분포되는 위치에 따라 콜라겐의 type이 다르게 구분되어 있습니다. 콜라겐 type 4는 basal laminas에 주로 존재하는 콜라겐 형태입니다. 첨부한 자료에 type 1-4에 대한 도식화된 표를 보시면 이해가 될 것입니다. 도움이 되시길 바라며....

혈관내피를 만드는 방법에 있어 biomaterial을 이용하는 방법에 대해 잘 정리된 Review 논문입니다. 참고가 되었으면 합니다. 저도 조직공학 연구자로써 Fibrin sealant를 연구하고 있습니다. 우선적으로는 골재생에 관련된 연구에 집중하고 있으며, 기타 다른 분야에 대한 연구에도 관심을 기울이고 있습니다. 필요하다면 보다 많은 정보를 교환할수 있는 기회가 될 수도 있을 것같습니다. 첨부한 논문의 요약문입니다. ADR-11544; No of Pages 14 Matrices and scaffolds for drug delivery in vascular tissue engineering☆ Ge Zhang, Laura J. Suggs Department of Biomedical Engineering, University of Texas at Austin, 1 University Station C0800, Austin, TX 78712, USA Received 31 December 2006; accepted 28 March 2007 The purpose of this review is to give an overview of strategies using natural and artificial substrates to present active biomolecules in the development of vascular structures. Two primary topics are discussed. The first is the replacement and augmentation of arteries using vascular grafts or stents. Second is the recruitment of microvasculature secondary to an ischemic event or for the purpose of developing perfused, largevolume tissue-engineered constructs. Significant overlap exists among these topics. The focus is therefore on specific drug delivery strategies with discussion of a number of emerging themes. Where applicable, results from clinical trials have been included. Early work in the field includes covalent and nonspecific immobilization of growth factors, while more recent work emphasizes biologically inspired control over localization and temporal presentation. Novel strategies for matrix-mediated release can deliver multiple growth factors and/or cells in a manner that mimics tissue development and healing. Challenges that remain within this field center on controlling reciprocal interactions among the three fundamental tissue engineering components of scaffolds, cells and signals.