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지식나눔

지식나눔

knock out rat

2013-03-12 org.kosen.entty.User@2b185455 이승규(sklee0125)
  • 1
rat에서 knockout이 2008년이 되어서야 가능해졌다고 하는데, mice에 비해 이렇게 늦게 시작된 이유가 무엇입니까?
  • rat
  • knock out
  • mice
지식의 출발은 질문, 모든 지식의 완성은 답변! 
각 분야 한인연구자와 현업 전문가분들의 답변을 기다립니다.
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    김채형님의 답변

    2013-03-25
    • 0

    첨부파일

    Most techniques for genetic manipulation, including random mutagenesis with a gene trap (retroviral-based and non-retroviral-based), gene knock-outs/knock-ins, and conditional mutations, depend upon the culture and manipulation of embryonic stem (ES) cells. Rat ES cells were only recently isolated and no demonstration of gene modification in them has been reported. Consequently, many genetic manipulation techniques widely used in the mouse are not possible in the rat.
    답변수정
    Most techniques for genetic manipulation, including random mutagenesis with a gene trap (retroviral-based and non-retroviral-based), gene knock-outs/knock-ins, and conditional mutations, depend upon the culture and manipulation of embryonic stem (ES) cells. Rat ES cells were only recently isolated and no demonstration of gene modification in them has been reported. Consequently, many genetic manipulation techniques widely used in the mouse are not possible in the rat.
    등록된 댓글이 없습니다.
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