Most animal cells are asymmetrically polarized and exhibitapical-basal polarity. Even non-polarized cells such as fibroblasts and single cells such as yeasts show apical-basal polarity, suggesting that some intrinsic factors in cells determine the cell polarity. The cell polarity can be obtained by delivery of post-Golgi vesicles precisely to the specified membrane addition site, and this process is essential not only for the establishment of cell polarity but also for supplying the membrane lipids and proteins to the proliferating cells. Thus, disruption in this process results in loss of cell polarity as well as disruption in cell proliferation, two of the hallmarks of cancer cells.
국가
대한민국
소속기관
한국과학기술원 (학교)
연락처
042-869-2618 http://bs.kaist.ac.kr/~acelab/
책임자
이균민 gyunminlee@kaist.ac.kr