2012-07-09
org.kosen.entty.User@190f90a0
김소연(sykim0807)
We are now beginning to understand the biological phenomena as a complex network system with a hierarchical architecture. Since typical dynamics of most biological systems are not linear, merely understanding molecular events cannot simply lead us to the holistic understanding of the cellular responses to the specific stimuli under the various contexts. The ultimate goal of our computational cell biology laboratory is to delineate the dynamics underlying the complex cellular responses, which resembles a "chaotic system." We utilize biological tools of various systems to investigate the complex behaviors of cells, by developing specific mathematical models, which will be validated by computational simulation methods. To develop predictable mathematical models for various human disorders such as Alzheimers disease, atherosclerosis and brain tumors, we especially focus on the intracellular biochemical networks responsible for proliferation, inflammation, angiogenesis and apoptotic cell death.
#Development of early diagnostic tool for neurodegenerative diseases based on retinal neurovascular coupling #Dynamic Fluorescence Imaging for functional monitoring of tumor vasculatures #Delineation of novel crosstalk mechanism between TGF-β and TNF-α signaling pathways.