Current Research Interests
We use nuclear magnetic resonance (NMR) spectroscopy to gain insight into protein aggregation processes and biomolecular interactions. Intrinsically disordered proteins (IDP), whose aggregation in human brains are often responsible for neurological disorders, are used as model systems to investigate protein aggregation and disaggregation processes. Key factors that determine the interface and affinity of biomolecular interactions are sought for, again assisted by NMR spectroscopy together with other physical chemistry and biophysical techniques. These aggregation and interaction studies will eventually be performed inside a cellular milieu, as an effort to understand health and cure disease starting from the physical chemistry level.
We use nuclear magnetic resonance (NMR) spectroscopy to gain insight into protein aggregation processes and biomolecular interactions. Intrinsically disordered proteins (IDP), whose aggregation in human brains are often responsible for neurological disorders, are used as model systems to investigate protein aggregation and disaggregation processes. Key factors that determine the interface and affinity of biomolecular interactions are sought for, again assisted by NMR spectroscopy together with other physical chemistry and biophysical techniques. These aggregation and interaction studies will eventually be performed inside a cellular milieu, as an effort to understand health and cure disease starting from the physical chemistry level.