Current Research Interests
The protein-protein (or membrane lipid) interplays are central to almost every aspect of cell biology. We are interested in fundamental questions of how the interactions between proteins and proteins (or membranes) determine cell and organelle shape, how protein-protein or protein-lipid interactions turn on and off the signals that control essential cell processes including cytokinesis, which is the final stage of cell division. We are also highly interested in determining atomic structures of membrane proteins.
It is easy to agree that "Seeing is believing". The roots of our research are in the power of x-ray crystallography to reveal the structures of biomolecules at atomic level, leading to insights in the physical basis of protein-protein interactions. The core approach is complemented by studies in solution or on membranes by hydrodynamic, small angle x-ray scattering, fluorescence imaging, and electron microscopy. The structural, biochemical, and biophysical experiments lead to new hypotheses about biological function and mechanism. We also try to demonstrate our new hypotheses in cells using various cell biological tools.
Crystal structures of drug target proteins can also be used to discover new lead compounds by structure-based drug discovery (SBDD) method. We are interested in various drug target proteins to treat various diseases including cancer.
The protein-protein (or membrane lipid) interplays are central to almost every aspect of cell biology. We are interested in fundamental questions of how the interactions between proteins and proteins (or membranes) determine cell and organelle shape, how protein-protein or protein-lipid interactions turn on and off the signals that control essential cell processes including cytokinesis, which is the final stage of cell division. We are also highly interested in determining atomic structures of membrane proteins.
It is easy to agree that "Seeing is believing". The roots of our research are in the power of x-ray crystallography to reveal the structures of biomolecules at atomic level, leading to insights in the physical basis of protein-protein interactions. The core approach is complemented by studies in solution or on membranes by hydrodynamic, small angle x-ray scattering, fluorescence imaging, and electron microscopy. The structural, biochemical, and biophysical experiments lead to new hypotheses about biological function and mechanism. We also try to demonstrate our new hypotheses in cells using various cell biological tools.
Crystal structures of drug target proteins can also be used to discover new lead compounds by structure-based drug discovery (SBDD) method. We are interested in various drug target proteins to treat various diseases including cancer.
국가
대한민국
소속기관
서울대학교 (학교)
연락처
02-880-4130 http://sblabsnu.creatorlink.net/
책임자
이형호 hyungholee@snu.ac.kr