- Design and Synthesis of potential antitumor agents. Various novel heterocyclic compounds are designed and synthesized targeting topoisomerase II and NF-kB. One of our library is launched for the treatment of NSCLC. Development of reaction methodology for constructing novel heterocylcic scaffold is also pursued.
- Design and Synthesis of neuroprotective agents. Lipid peroxidation is an important mediator of pathophysiological events in central nervous system disorders such as cerebral ischemia and trauma. Lipid peroxidation is induced by free radicals with the major species of reactive oxygen species (ROS). ROS are by-products of a variety of pathways of aerobic metabolism. They are unstable and react readily with a wide range of biological substrates such as lipids, DNA, and protein, resulting in cell damage. Lipids of biological membranes, especially those in the brain contain highly oxidizable polyunsaturated fatty acids and are particularly vulnerable to free-radical-induced damage. Moreover, the brain contains considerable amounts of prooxidant transition metal ions and utilizes a lot of oxygen. Design and synthesis of novel heterocyclic compounds are pursued to identify neuroprotective agents
국가
대한민국
소속기관
충북대학교 (학교)
연락처
책임자
이희순 medchem@chungbuk.ac.kr