KOSEN 한인과학기술자네트워크

Bio Material Laboratory

Instructions
An exciting ‘natural material’ of new various research fields such as a antimicrobial, anticancer and atopy remedy has emerged from intense efforts these days to more effectively explore the rich chemical diversity offered in nature. As you can see right picture, our research field can distinguish 3 themes. Firstly, in biotechnology field of our lab includes antimicrobial, anticancer and antifungal. If the natural materials are used to treat in human, there will have no side effects. Secondly, health care field includes natural & functional cosmetics made natural extracts such as a shampoo, skin care. Lastly, pharmaceutical technology field includes atopy and pimple remedy. The change of the environmental contamination and food habit caused the skin disease of the human body.

Analysis of nutrient for developing of functional food extracted seaweed
Since ancient times, seaweed has been used as medicinal, food or raw material of seafood industry. Recently, it was recognized as a health product and has a move for using as full-fledged food. In a research, it is the precursor that the functional protection and crapulence reel ability of cocoon, and etc. which it goes with an anti-cancer, blood sugar subhepatic space, and oxygen-resistant by using the seaweed got water extract develop the manufacturing technique of the easy functional food and cosmetic. Then we carried out the analysis of the nutrient component of various forms and measured the antioxidant activity.
Effect of complex mushrrom and sharp toothed eel extracts on the skin conditions with atopic dermatitis and acne symptoms

In order to investigate effect of complex mushroom and sharp toothed eel extracts on the skin conditions with atopic dermatitis and acne symptoms, sharp toothed eel (Muraaensoy cinereus) and 7 kinds of mushrooms including Tremella fuciformis, Cordyceps militaris, Ganoderma lucidum, Lentinus edodes, Agaricus blazei Muril, Phellinus linteus, and Inonotus obliquus were used. The total phenol concentration was affected by extraction solvents. The phenol concentration was increased in order of hot water> ethanol> ethyl acetate> petroleum ether> chloroform. Especially, when hot water extract was used, it was about 2-3 fold higher than that of ethyl acetate, petroleum ether, and chloroform. When extract concentration of complex mushroom and sharp toothed eel was increased from 1.0 to 50 mg/L, the DPPH scavenging rate increased from 10.1 to 81.4%. The reduction power was sharply increased from 0.05 to 0.27(700nm) when extract concentration of complex mushroom and sharp toothed eel was increased from 25 to 75 mg/L. However, above 100mg/l, it was not decreased. In the case of SOD-like activity, it was 45.7% at 100mg/L. Total numbers of patients with atopic dermatitis were 15 and 5 patients with severe acne symptoms. According to photos taken before and after the treatment and questionnaire results, considerable improvements in skin conditions are observed in the patients with atopic dermatitis and acne. For atopic patients, erythema and edema have been improved but the degree of effect was dependent on the individual’s constitution. Concerning acne, the effect of coating of the extracts was prominent for first week and the degree decreased with time till 4 weeks. The complex extracts were efficient in soothing rash and maturation. Side effects such as a scar were not detected during the application and treatment. For patients with both symptoms, oil and moisture balance were good also Main text