KOSEN 한인과학기술자네트워크

Research

Research interests of "RNA Biochemistry & Superbacteria Research Lab": 

Misuse of antibiotics has induced the generation of a whole population of MDR (Multidrug resistant) bacteria. For instance, the mistreatment or misdiagnosis of patients with inappropriate antibiotics, coupled with insufficient knowledge of the origin of infection, has cast a shadow over the antibiotic medical miracle. To avoid the erruption of MDR bacteria as superbugs, understanding the underlined mechanisms by which bacteria acquire antibiotic resistance very rapidly.

Major topics of RNA Biochemistry & Superbacteria Research Lab:
 
1. Regulation of antibiotic resistance: identification of novel antibacterial target genes and seeking for the combinatorial materials to improve the efficacy of current last-resort antibiotics
2. Applications of the newly identified knowledge to both the diagnosis and treatment of specific antibiotic resistant superbugs by new-concept antibacterials.
3. Identification and development of new biologically non-toxic materials in killing G(-) and G(+) bacteria
4. Development of new concept antibiotics and vaccines against infectious diseases
5. Biogenesis of Outermembrane vesicles
The key subjects on above topics:
1. Mechanisms that control the expression and decay of cellular RNAs by environmental stresses
2. Unraveling the bacterial and eukaryotic small noncoding RNAs and their functions in infectious or human diseases
3. Development of monitoring systems in the analysis of functional molecules
4. Design new vaccine production systems for infectious diseases
5. Chemical screening for functional molecules against infectious diseases

Selected Keywords for research topics:
Ribonuclease, Small noncoding RNA, Pathogen, Reporter system, Antibiotic resistance, Trans-acting regulators, Biofilm, Outermembrane Vesicles

Selected Publications at PubMed: