- Databases
- MACE
- Mutation-oriented analysis of che- mical response in cancer cell lines
- GS-LAGE
- A novel gene-specific analysis of microarray global data
- NetCSSP
- Prediction of chameleon seq. and amyloid fibril formation
- Tools
- Qhelix
- Analysis of geometric arrangement
of protein helices
- QCanvas
- Fast clustering and
visualization of data
- Qsurface
- Identification of cell surface
transcriptome markers in cancers
- Smart screening for systems medicines
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Availability of multi-level omics data such as genome, transcriptome, proteome and phosphatome data enables system-level analyses for the prediction and characterization of selective drug response on target diseases.
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Integration of multi-level omics data with chemical or siRNA screening data on diverse biological samples is accelerating discovery studies on clinically relevant drug applications and their mode of actions.
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For this purpose, we have constructed a smart screening platform combining technologies on computer-oriented big data mining and experimental high content screening for last several years.
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- ▶ 1. Pan-omics data mining and screening
Method development and optimization for big data analysis- Generate diverse patterns and hypotheses describing the association between varied drug
- response and molecular signatures such as mutation, gene or protein markers.
- Validation of target molecules and samples for the optimization of high content siRNA or
- chemical library screening
- ▶ 2. High throughput siRNA and chemical library screening
- Image and cell-based assay development for high content screening
- Automation and standardization of high throughput screening
- System-level interpretation of siRNA library screening
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- ▶ 3. Molecular modeling and drug design
- Application of machine learning algorithms for cell-based SAR studies
- 3D shape-based chemical analysis
- Protein and peptide sequence optimization
국가
대한민국
소속기관
숙명여자대학교 (학교)
연락처
02-710-9415 http://bioinfo.sookmyung.ac.kr/
책임자
윤석준 yoonsj@sookmyung.ac.kr