(review) The Functional Analysis of Histone Acetyltransferase
2016-02-14
org.kosen.entty.User@1d152e17
오현철(dhguscjf)
행사&학회소개
1. Introduction
2. MOF Belongs to the MYST Family of HATs.
3. MOF Forms Two Distinct Multiprotein Complexes in Cells
4. MOF Plays a Critical Role in Cells
5. Roles of MOF in Tumorigenesis
6. Conclusions and Perspectives
2. MOF Belongs to the MYST Family of HATs.
3. MOF Forms Two Distinct Multiprotein Complexes in Cells
4. MOF Plays a Critical Role in Cells
5. Roles of MOF in Tumorigenesis
6. Conclusions and Perspectives
보고서작성신청
Human MOF (males absent on the first) is a member of the MYST (Moz-Ybf2/Sas3-Sas2-Tip60) family of histone acetyltransferases (HATs). As a catalytic subunit, MOF can form at least two distinct multiprotein complexes (MSL and NSL) in human cells. In this review, we provide a brief overview of MOF and its corresponding histone acetylation, introduce recent research findings that link MOF functions to tumorigenesis and speculate on the potential role that may be relevant to tumorigenic pathways.