An Integrated View of Immunometabolism
2018-01-18
org.kosen.entty.User@37455be7
조준석(jscho0191)
분야
생명과학
개최일
1.11.2018
신청자
조준석(jscho0191)
개최장소
URL
행사&학회소개
Introduction
Establishing a Link between Chronic Inflammation and Metabolic Disease
Tissue-Specific Events in Development of Insulin Resistance and Glucose Intolerance
1. Adipose Tissue
- Adipose Tissue Macrophages
- Other Innate Immune Cell Types
- Lymphocytes
- Triggers for Adipose Tissue Inflammation
- The Upside of Adipose Inflammation
- Metabolically Normal and Abnormal Obesity
2. Liver
- Kupffer Cells and Recruited Macrophages
- Neutrophils
- Pathological Effects of Liver Inflammation
3. Muscle
4. Pancreatic Islets
- Islet Macrophages and Inflammation
- Intracellular Mechanisms for Inflammation-Induced β-Cell Dysfunction
- IL-1β
- Potential Beneficial Effects of Islet Macrophages
5. Central Nervous System
- CNS Inflammation in Obesity
- Inflammation Affects Central Leptin and Insulin Resistance in Obesity
6. Gastrointestinal Tract
- Obesity Leads to Altered GI Microbiota Composition
- Microbiota-Produced Metabolites Influence Host Inflammation and Metabolism
- Obesity Leads to Increased GI Permeability and Endotoxemia
- Modulation of the Host Immune System by GI Microbiota
Intraorgan Crosstalk
Interorgan Crosstalk and Communication
Therapeutic Implications
Establishing a Link between Chronic Inflammation and Metabolic Disease
Tissue-Specific Events in Development of Insulin Resistance and Glucose Intolerance
1. Adipose Tissue
- Adipose Tissue Macrophages
- Other Innate Immune Cell Types
- Lymphocytes
- Triggers for Adipose Tissue Inflammation
- The Upside of Adipose Inflammation
- Metabolically Normal and Abnormal Obesity
2. Liver
- Kupffer Cells and Recruited Macrophages
- Neutrophils
- Pathological Effects of Liver Inflammation
3. Muscle
4. Pancreatic Islets
- Islet Macrophages and Inflammation
- Intracellular Mechanisms for Inflammation-Induced β-Cell Dysfunction
- IL-1β
- Potential Beneficial Effects of Islet Macrophages
5. Central Nervous System
- CNS Inflammation in Obesity
- Inflammation Affects Central Leptin and Insulin Resistance in Obesity
6. Gastrointestinal Tract
- Obesity Leads to Altered GI Microbiota Composition
- Microbiota-Produced Metabolites Influence Host Inflammation and Metabolism
- Obesity Leads to Increased GI Permeability and Endotoxemia
- Modulation of the Host Immune System by GI Microbiota
Intraorgan Crosstalk
Interorgan Crosstalk and Communication
Therapeutic Implications
보고서작성신청
세계적으로 확산되고 있는 비만은 인슐린 저항성과 제2형 당뇨의 주요 원인이다. 조직의 만성 염증은 비만의 특징으로 관련 면역대사 연구가 활발히 진행 중에 있다. 본 분석은 비만 관련 만성 염증이 여러 조직에서 어떻게 인슐린 민감도, 인슐린 분비, 포도당 항상성 등에 영향을 미치는지 정리하고, 현재와 미래의 가능한 치료법등을 전망한다.