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NIH VideoCast - Open Science and the second scientific revolution: A future history

- Jason Priem, Cofounder, Impactstory (2018/07/03)
- Category : Special

NIMH Data Science Jason is a leading voice in advocating for alternative impact metrics and open access. For more information on his work see http://jasonpriem.org

NIH VideoCast - Open Science and the second scientific revolution: A future history

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NIH VideoCast - Joint Meeting of the NCI Board of Scientific Advisors (BSA) and the National Cancer Advisory Board (NCAB)- June 2018 (Day 2)

- NCI, NIH (2018/06/29)
- Category : NCI Board of Scientific Advisors

The 11th Joint Meeting of the NCI Board of Scientific Advisors and the National Cancer Advisory Board (Day two of two)

NIH VideoCast - Joint Meeting of the NCI Board of Scientific Advisors (BSA) and the National Cancer Advisory Board (NCAB)- June 2018 (Day 2)

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NIH VideoCast - CC Grand Rounds: 1) Sequencing Approaches to Understand Diamond Blackfan Anemia Syndrome 2) Deficiency of ADA2 (DADA2): The Expanding Spectrum of Phenotypes of a Not-so-Rare Monogenic Autoinflammatory Disease

- 1) David Bodine, PhD, Chief and Senior Investigator, Genetics and Molecular Biology Branch and Head, Hematopoiesis Section, NHGRI, NIH 2) Ivona Aksentijevich, MD, Associate Investigator, Inflammatory Disease Section, Metabolic, Cardiovascular and Inflammatory Disease Genomics Branch, NHGRI, NIH (2018/06/29)
- Category : Clinical Center Grand Rounds

CC Grand Rounds: 1) Sequencing Approaches to Understand Diamond Blackfan Anemia Syndrome 2) Deficiency of ADA2 (DADA2): The Expanding Spectrum of Phenotypes of a Not-so-Rare Monogenic Autoinflammatory Disease For more information go to https://www.cc.nih.gov/about/news/grcurrent.html

NIH VideoCast - CC Grand Rounds: 1) Sequencing Approaches to Understand Diamond Blackfan Anemia Syndrome 2) Deficiency of ADA2 (DADA2): The Expanding Spectrum of Phenotypes of a Not-so-Rare Monogenic Autoinflammatory Disease

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NIH VideoCast - Decoding the genome regulatory program for T-cell identity

- Ellen V. Rothenberg, Ph.D., Albert Billings Ruddock Professor of Biology, California Institute of Technology (2018/06/29)
- Category : WALS - Wednesday Afternoon Lectures

NIH Director？？？s Wednesday Afternoon Lecture Series T cells develop in the thymus from precursor cells that have migrated there while they still have the potential to give rise to multiple cell types. The decision of each precursor to become a T cell rather than another kind of cell is then established gradually in response to thymic environmental signals of Notch pathway activators and a limited set of growth factors. This multistep process involves a cascade of changes in the expression of different regulatory genes and resulting changes in global genome-wide activity. As the cells start their pathway to a T-cell fate, they come dangerously close to a gene-expression pattern typical of malignancy before they become safely locked into their T-cell identity. However, the developmental process is normally very effective at silencing the oncogenic genes at the right times as well as at endowing the cells with the qualities they will need to become useful T cells. When and how does this process resolve correctly and how does it reach a point of no return? Dr. Rothenberg？？？s lecture will present answers from the levels of gene-expression control, gene-regulatory networks, and dynamic single-cell imaging of the developmental process in real time.

NIH VideoCast - Decoding the genome regulatory program for T-cell identity

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NIH VideoCast - Clinical Cardiovascular Research Inspired by the NHLBI: A Personal Odyssey

- Eugene Braunwald, MD, Brigham and Women？？？s Hospital and Harvard University (2018/06/29)
- Category : Special

The NHLBI 70th Anniversary Lecture Series is designed to highlight not only significant advancements in the field of heart, lung, blood, and sleep research, but to also provide a visionary perspective of the promising opportunities ahead including addressing some of the most compelling questions and critical challenges elicited in the 2016 NHLBI Strategic Vision. The lectures include presentations from thought leaders in the medical field. All clinicians, trainees including fellows, medical students, Ph.D. students, healthcare and research professionals, and interested members of the public. For more information go to https://www.nhlbi.nih.gov/events/2018/clinical-cardiovascular-research-inspired-nhlbi-personal-odyssey-0

NIH VideoCast - Clinical Cardiovascular Research Inspired by the NHLBI: A Personal Odyssey

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NIH VideoCast - Joint Meeting of the NCI Board of Scientific Advisors (BSA) and the National Cancer Advisory Board (NCAB) - June 2018 (Day 1)

- NCI, NIH (2018/06/28)
- Category : NCI Board of Scientific Advisors

The 11th Joint Meeting of the NCI Board of Scientific Advisors and the National Cancer Advisory Board (Day one of two).

NIH VideoCast - Joint Meeting of the NCI Board of Scientific Advisors (BSA) and the National Cancer Advisory Board (NCAB) - June 2018 (Day 1)

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NIH VideoCast - DNA Repair Interest Group - A comprehensive repertoire of mutational signatures in human cancer

- Dr. Ludmil Alexandrov, UCSD (2018/06/26)
- Category : DNA Repair

DNA Repair Interest Group videoconference

NIH VideoCast - DNA Repair Interest Group - A comprehensive repertoire of mutational signatures in human cancer

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NIH VideoCast - NCI Council of Research Advocates (NCRA) - June 2018

- Office of Advocacy Relations, NCI, NIH (2018/06/23)
- Category : Advisory Board Meetings and Workshops

The 76th meeting of the NCI Council of Research Advocates (NCRA) will be taking place on June 21, 2018. The meeting will start at 9:30am and end at 4:00pm.

NIH VideoCast - NCI Council of Research Advocates (NCRA) - June 2018

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NIH VideoCast - Cell and genome organization in mitosis, development, and homeostasis

- Yixian Zheng, Ph.D., Carnegie Institution for Science (2018/06/22)
- Category : WALS - Wednesday Afternoon Lectures

NIH Director？？？s Wednesday Afternoon Lecture Series I began my research career studying how microtubules regulate various cellular processes, especially microtubule assembly, mitotic spindle assembly, and chromosome segregation. As a PhD student in Dr. Berl Oakley？？？s lab, my study of g-tubulin has inspired me to use biochemical approaches to investigate the mechanism of microtubule nucleation as a postdoctoral fellow in Drs. Bruce Alberts and Tim Mitchison？？？s labs at UCSF. This has led to the discovery of the g-tubulin ring complex (gTuRC) and the demonstration of its microtubule-nucleating activity from purified tubulins. After establishing my lab, we discovered the role of RanGTPase in regulating spindle assembly in mitosis. Our more recent study of the mitotic spindle matrix has led to the finding that the nuclear lamin-B is part of the spindle matrix. We show that lamin-B plays a role in mitotic spindle morphogenesis and spindle orientation. In recent years, our research has expanded into studying the role of lamins in the interphase nucleus. By analyzing lamin deletions in mice, mouse ES cells, and various Drosophila stem cells, we have shown that lamins play important roles in organogenesis during development. Additionally, we show that lamin-B prevents immunosenescence and system inflammation upon organismal aging by maintaining the heterochromatin in immune organs.

NIH VideoCast - Cell and genome organization in mitosis, development, and homeostasis

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NIH VideoCast - NCI Support for Cancer Immunology

- Norman E. Sharpless, M.D., Director, National Cancer Institute, NIH (2018/06/22)
- Category : Immunology

Immunonology IG Seminar Norman E. ？？？Ned？？？ Sharpless, M.D., was officially sworn in as the 15th director of the National Cancer Institute (NCI) on October 17, 2017. Prior to his appointment, Dr. Sharpless served as the director of the University of North Carolina (UNC) Lineberger Comprehensive Cancer Center, a position he held since January 2014. Dr. Sharpless was a Morehead Scholar at UNC？？？Chapel Hill and received his undergraduate degree in mathematics. He went on to pursue his medical degree from the UNC School of Medicine, graduating with honors and distinction in 1993. He then completed his internal medicine residency at the Massachusetts General Hospital and a hematology/oncology fellowship at Dana-Farber/Partners Cancer Care, both of Harvard Medical School in Boston. After 2 years on the faculty at Harvard Medical School, he joined the faculty of the UNC School of Medicine in the Departments of Medicine and Genetics in 2002. He became the Wellcome Professor of Cancer Research at UNC in 2012. Dr. Sharpless is a member of the Association of American Physicians as well as the American Society for Clinical Investigation (ASCI), the nation？？？s oldest honor society for physician？？？scientists, and served on the ASCI council from 2011 to 2014. Dr. Sharpless was an associate editor of Aging Cell and deputy editor of the Journal of Clinical Investigation. He has authored more than 150 original scientific papers, reviews, and book chapters, and is an inventor on 10 patents. He cofounded two clinical-stage biotechnology companies: G1 Therapeutics and HealthSpan Diagnostics. In addition to serving as Director of NCI, Dr. Sharpless continues his research in understanding the biology of the aging process that promotes the conversion of normal self-renewing cells into dysfunctional cancer cells. Dr. Sharpless has made seminal contributions to the understanding of the relationship between aging and cancer, and in the preclinical development of novel therapeutics for melanoma, lung cancer, and breast cancer.

NIH VideoCast - NCI Support for Cancer Immunology

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NIH VideoCast - CC Grand Rounds 1) Recent Advances in Myositis Pathogenesis and Treatment: Understanding Risk Factors and Mechanisms in Myositis 2) Developments in the Assessment and Treatment of Myositis

- 1) Frederick W. Miller, MD, PhD Deputy Chief, Clinical Research Branch and Head, Environmental Autoimmunity Group, NIEHS, NIH 2) Lisa G. Rider, MD Deputy Unit Chief, Environmental Autoimmunity Group, Clinical Research Branch, NIEHS, NIH (2018/06/21)
- Category : Clinical Center Grand Rounds

CC Grand Rounds 1) Recent Advances in Myositis Pathogenesis and Treatment: Understanding Risk Factors and Mechanisms in Myositis 2) Developments in the Assessment and Treatment of Myositis For more information go to https://www.cc.nih.gov/about/news/grcurrent.html

NIH VideoCast - CC Grand Rounds 1) Recent Advances in Myositis Pathogenesis and Treatment: Understanding Risk Factors and Mechanisms in Myositis 2) Developments in the Assessment and Treatment of Myositis

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NIH VideoCast - National Advisory Eye Council (NAEC) - June 2018

- NEI, NIH (2018/06/20)
- Category : Advisory Board Meetings and Workshops

Paul A. Sieving, MD, PhD, the Director of the National Eye Institute (NEI), presides as Chair and Paul A. Sheehy, Ph.D., as Executive Secretary to the National Advisory Eye Council (NAEC). The meeting is open to the public from 9:30 a.m. until 2:30 p.m. then the meeting will be closed to the public for the review of confidentiality and conflict of interest procedures and a review of grant and cooperative agreement applications on visual disorders, preservation of sight, and the special health problems and requirements of individuals with visual impairments. It also conducts the second level peer review of grant applications. For more information go to https://nei.nih.gov/about/naec

NIH VideoCast - National Advisory Eye Council (NAEC) - June 2018

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NIH VideoCast - HEALing Communities Study Design Workshop

- NIH (2018/06/20)
- Category : Conferences

A group of creative and innovative scientific experts, state and federal partners, and other key stakeholders will meet for a one-day meeting to solicit input regarding important aspects of study design.

NIH VideoCast - HEALing Communities Study Design Workshop

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NIH VideoCast - Confronting the Opioid Crisis by Developing New Measurements and Biomarkers of Pain

- Clifford Woolf, MB, BCh, Ph.D., Boston Children`s Hospital, Harvard (2018/06/20)
- Category : Neuroscience

NIH Neuroscience Series Seminar Neuronal plasticity, its mechanistic basis, how it contributes to the normal and abnormal functions of the nervous system, and how it can be a target for therapy comprise the major focus of Dr. Woolf？？？s investigations. Specifically, he studies neural plasticity in relation to pain, regeneration, neurodegenerative disorders and developmental neurobiology. Dr. Woolf has spearheaded discoveries on how functional synaptic plasticity, structural reorganization of synaptic architecture, injury-induced transcriptional changes, neuro-immune interactions and activity-dependent loss of interneurons all contribute to the pathogenesis and maintenance of pain. He has linked polymorphisms in human genes with the risk of developing pain and has pioneered new ways of phenotyping pain in patients. His work has led to the identification of novel targets for analgesics, and, with Bruce Bean at HMS, he has discovered a way of producing a long-lasting local analgesia. With Lee Rubin at HU, he has converted human embryonic stem cells into pain neurons for disease modeling and testing analgesics and with Josef Penninger used genome-wide screens in Drosophila to identify novel pain genes. Additionally, Dr. Woolf has explored how axonal injury activates a survival and regeneration program in sensory and motor neurons, and he has identified the transcription factors that act as master regulators of these. This has led to novel genetic approaches to increase regeneration and ameliorate motor neuron disease. Currently devoted to investigating how the functional, chemical and structural plasticity of neurons contributes to adaptive and maladaptive functions of the mammalian nervous system, the Woolf lab？？？s major efforts are dedicated to the study of pain, the formation of neural circuits during development, and the failure of regeneration in the adult CNS. Most of this work is focused on primary sensory and spinal cord neurons, which are studied using a multidisciplinary approach that spans mouse and human genetics, molecular and cell biology, bioinformatics, synaptic electrophysiology, neuroanatomy, integrative systems biology and behavior. Dr. Woolf lab represents a complex mixture of basic and translational neuroscience and works closely with a wide number of academic groups and the pharmaceutical and biotechnology industry to identify and validate molecular targets for novel analgesics and axonal growth determinants. For more information go to https://neuroscience.nih.gov/neuroseries/Home.aspx

NIH VideoCast - Confronting the Opioid Crisis by Developing New Measurements and Biomarkers of Pain

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NIH VideoCast - Contemporary Clinical Medicine: Great Teachers: John Laws Decker Memorial Lecture: The Dark Side of ？？？Explaining？？？: Misattribution and Misclassification

- James D. Katz, MD, Director, NIAMS Rheumatology Fellowship Program, and Chief, Training Branch and Staff Clinician, NIAMS, NIH (2018/06/19)
- Category : Clinical Center Grand Rounds

Contemporary Clinical Medicine: Great Teachers: John Laws Decker Memorial Lecture: The Dark Side of ？？？Explaining？？？: Misattribution and Misclassification For more information go to https://www.cc.nih.gov/about/news/grcurrent.html

NIH VideoCast - Contemporary Clinical Medicine: Great Teachers: John Laws Decker Memorial Lecture: The Dark Side of ？？？Explaining？？？: Misattribution and Misclassification

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NIH VideoCast - Heterogeneity and Plasticity of CD4 T Helper (Th) and Innate Lymphoid Cell (ILC) Subsets

- Jinfang Zhu, Ph.D., National Institute of Allergy and Infectious Diseases, NIH (2018/06/19)
- Category : Immunology

Immunonology IG Seminar Dr. Jinfang Zhu received his Ph.D. in biochemistry and molecular biology from the Shanghai Institute of Biochemistry, Chinese Academy of Sciences. He completed his postdoctoral training at the Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, with late Dr. William E. Paul, studying CD4 T helper cell differentiation controlled by key transcription factors including GATA3 and T-bet. He started his own group in the Laboratory of Immunology as an Earl Stadtman investigator, and is now the section chief of the Molecular and Cellular Immunoregulation Section in the Laboratory of Immune System Biology. His lab studies functional heterogeneity and plasticity of CD4 T helper and innate lymphoid cell subsets using transcription factor locus driven reporter and fate mapping mice.

NIH VideoCast - Heterogeneity and Plasticity of CD4 T Helper (Th) and Innate Lymphoid Cell (ILC) Subsets

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NIH VideoCast - Advisory Committee to the Director - June 2018 (Day 2)

- Office of the Director, NIH (2018/06/19)
- Category : Advisory Committee to the Director of the NIH

Advisory Committee to the Director For more information go to https://acd.od.nih.gov

NIH VideoCast - Advisory Committee to the Director - June 2018 (Day 2)

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NIH VideoCast - 2018 Lipsett Lecture: "Oncofertility: From Bench to Bedside to Babies"

- Dr. Teresa K. Woodruff, Dean and Associate Provost for Graduate Education, The Graduate School at Northwestern University and Thomas J. Watkins Professor of Obstetrics & Gynecology, the Vice Chair for Research and the Chief of the Division of Reproductive Science in Medicine, Department of Obstetrics and Gynecology, Fienberg School of Medicine, Professor of Molecular Biosciences, Weinberg College of Arts and Sciences, Professor of Biomedical Engineering, McCormick School of Engineering, Director of the Center for Reproductive Science, Director of Women`s Health Research Institute, and Director of Oncofertility Consortium (2018/06/19)
- Category : Special

The Lipsett Lecture is an annual lecture held by NICHD to honor Dr. Mortimer B. Lipsett, Director of the National Institute of Arthritis, Diabetes, and Digestive and Kidney Diseases, National Institutes of Health (NIH), who died of cancer on November 10, 1985 at the Clinical Center. This year`s speaker will be Dr. Teresa K. Woodruff, Dean and Associate Provost for Graduate Education in The Graduate School at Northwestern University and Thomas J. Watkins Professor of Obstetrics & Gynecology, the Vice Chair for Research and the Chief of the Division of Reproductive Science in Medicine in the Department of Obstetrics and Gynecology, Fienberg School of Medicine, Professor of Molecular Biosciences in the Weinberg College of Arts and Sciences, Professor of Biomedical Engineering in the McCormick School of Engineering, Director of the Center for Reproductive Science, Director of Women`s Health Research Institute, and Director of Oncofertility Consortium. She is an internationally recognized expert in ovarian biology and, in 2006, coined the term "oncofertility" to describe the merging of two fields: oncology and fertility. She now heads the Oncofertility Consortium, an interdisciplinary team of biomedical and social scientist experts from across the country. The title of her talk is, "Oncofertility: From Bench to Bedside to Babies".

NIH VideoCast - 2018 Lipsett Lecture: "Oncofertility: From Bench to Bedside to Babies"