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  • Structural and Digital Biology of Macromolecular Complexes
    • - Wah Chiu, Ph.D., Baylor College of Medicine (2010/03/04)
    • - Category : Wednesday Afternoon Lectures
    A typical biological process involves tens to hundreds of proteins to act in coordinated and concerted manner. Understanding their mechanism of actions requires the 3-dimensional photos of the complex at different physiological stages. This spatial and temporal information is critical for designing new therapeutic strategy to prevent or cure diseases. Typically a macromolecular complex has a molecular size close to or over one million Daltons. A hybrid of technologies in structural and digital biology is necessary to determine the structures of macromolecular complexes. This lecture will illustrate the combined use of electron cryomicroscopy, x-ray crystallography, bioinformatics and structural prediction to study a variety of macromolecular complexes including viruses, ion channels and machines.

    Wah Chiu

    The NIH Director's Wednesday Afternoon Lecture Series

    Structural and Digital Biology of Macromolecular Complexes

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  • Development of TNF Blockers for Rheumatoid Arthritis - Development of Recombinant Immunotoxins for Therapy of Cancer
    • - Lipsky, Peter E.
      National Institutes of Health (U.S.) (2010/03/04)
    • - Category : Clinical Center Grand Rounds

    Development of TNF Blockers for Rheumatoid Arthritis - Development of Recombinant Immunotoxins for Therapy of Cancer

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  • From Molecules to Mind: Stress, Individual Differences and the Social Environment
    • - McEwen, Bruce S.
      National Institutes of Health (U.S.) (2010/03/04)
    • - Category : Special

    From Molecules to Mind: Stress, Individual Differences and the Social Environment

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  • Federal and Private Sector Resumes
    • - NIH Work/Life Center (2010/03/04)
    • - Category : Work/Life Center
    Join our career consultant to explore the differences between Federal and private sector resumes, and learn how you can create resumes that best showcase your background, experience, and achievements.

    The NIH Work/Life Center, in conjunction with the Employee Assistance Program, is pleased to announce the "Faces and Phases of Life" seminar series. This successful series brings expert speakers to campus to address a broad range of quality of work and quality of life issues.

    For more information, visit
    http://wlc.od.nih.gov

    Federal and Private Sector Resumes

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  • Demystifying Medicine - Schizophrenia ??? Clinical Studies - Molecular and Genetic Factors
    • - Egan, Michael F.
      National Institutes of Health (U.S.) (2010/03/04)
    • - Category : Demystifying Medicine

    Demystifying Medicine - Schizophrenia ??? Clinical Studies - Molecular and Genetic Factors

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  • 2004 NIH Performance Management Guidance (NIH Only)
    • - Susan Fishbein, HR Specialist, Workforce Relations Division (2010/03/04)
    • - Category : NIH Only
    The briefing covers the current NIH Performance Management Requirements.

    For more information, visit
    http://hr.od.nih.gov/programs/performance/booklet.htm

    2004 NIH Performance Management Guidance (NIH Only)

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  • Frontiers of Knowledge in Sleep & Sleep Disorders: Opportunities for Improving Health and Quality of Life (Day 2)
    • - National Center on Sleep Disorders Research (National Heart, Lung, and Blood Institute) (2010/03/04)
    • - Category : National Center on Sleep Disorders Research (NHLBI)

    Frontiers of Knowledge in Sleep & Sleep Disorders: Opportunities for Improving Health and Quality of Life (Day 2)

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  • Unique Features of Neurotrophin Receptor Signaling
    • - Chao, Moses V.
      National Institutes of Health (U.S.) (2010/03/04)
    • - Category : Neuroscience

    Unique Features of Neurotrophin Receptor Signaling

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  • Frontiers of Knowledge in Sleep & Sleep Disorders: Opportunities for Improving Health and Quality of Life (Day 1)
    • - National Center on Sleep Disorders Research (National Heart, Lung, and Blood Institute) (2010/03/04)
    • - Category : National Center on Sleep Disorders Research (NHLBI)

    Frontiers of Knowledge in Sleep & Sleep Disorders: Opportunities for Improving Health and Quality of Life (Day 1)

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  • Functional Proteomics: Methods Development and Applications to Signal Transduction
    • - Natalie G. Ahn, Ph.D., University of Colorado (2010/03/04)
    • - Category : Wednesday Afternoon Lectures
    Functional proteomics provides a powerful approach to screen for molecular responses at the protein level. By combining 2D gels and mass spectrometry with standard molecular pharmacological strategies, responses to specific signal transduction pathways can be monitored. The results reveal novel targets for regulation by post-translational modification, which compliment information from gene array analyses. Applications to MAP kinase and Rho GTPase pathways will be presented. 2D-gel based approaches also reveal proteins that are differentially expressed between melanocyte vs melanoma cultured cell lines.

    For more information, visit
    Natalie Ahn

    NIH Director's Wednesday Afternoon Lecture Series.

    Functional Proteomics: Methods Development and Applications to Signal Transduction

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  • Structural Basis of MHC Recognition by Natural Killer Cell Receptors
    • - Mariuzza, Roy.
      National Institutes of Health (U.S.) (2010/03/04)
    • - Category : Immunology

    Structural Basis of MHC Recognition by Natural Killer Cell Receptors

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  • Boning Up on Osteoporosis: Emerging Therapies for Prevention and Treatment
    • - Joan McGowan, Connie Weaver, Mary Bouxsein, Deborah Sellmeyer, Allan Noonan and Joan Goldberg (2010/03/04)
    • - Category : Women's Health
    2003 Women???s Health Seminar Series

    Introductory Remarks
    Joan A. McGowan, Ph.D.
    National Institute of Arthritis and Musculoskeletal and Skin Diseases

    Role of Nutrition in Building Peak Bone Mass
    Connie M. Weaver, Ph.D.
    Purdue University

    Seeing a Silent Disease: Skeletal Imaging in Osteoporosis
    Mary L. Bouxsein, Ph.D.
    Beth Israel Deaconess Medical Center

    Evolution in Clinical Strategies--Putting It All Together
    Deborah E. Sellmeyer, M.D.
    University of California, San Francisco

    Panel Discussion/Questions and Answers
    Chaired by Allan S. Noonan, M.D., M.P.H.
    Office of the Surgeon General

    Invited Panelist:
    Joan R. Goldberg, Executive Director
    American Society for Bone and Mineral Research

    For more information, visit
    http://www4.od.nih.gov/orwh/2003Seminars.pdf

    Boning Up on Osteoporosis: Emerging Therapies for Prevention and Treatment

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  • NIH Consensus Development Conference on Total Knee Replacement (Day 2)
    • - National Institutes of Health Consensus Development Conference (2010/03/04)
    • - Category : Conferences

    NIH Consensus Development Conference on Total Knee Replacement (Day 2)

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  • Sleep Disorders Research Advisory Board - December 2003
    • - National Center on Sleep Disorders Research (NHLBI) (2010/03/04)
    • - Category : National Center on Sleep Disorders Research (NHLBI)
    The National Center on Sleep Disorders Research (NCSDR), located within the National Heart, Lung, and Blood Institute (NHLBI) of the National Institutes of Health (NIH), was established in 1993 to combat a serious public health concern. About 70 million Americans suffer from sleep problems; among them, nearly 60 percent have a chronic disorder. Each year, sleep disorders, sleep deprivation, and sleepiness add an estimated $15.9 billion to the national health care bill. Additional costs to society for related health problems, lost worker productivity, and accidents have not been calculated. Sleep disorders and disturbances of sleep comprise a broad range of problems, including sleep apnea, narcolepsy, insomnia, parasomnia, jet-lag syndrome, and disturbed biological and circadian rhythms.

    For more information, visit
    http://www.nhlbi.nih.gov/about/ncsdr/research/research4.htm

    Sleep Disorders Research Advisory Board - December 2003

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  • TRACO: Brain Cancer
    • - Fine, Howard.
      National Institutes of Health (U.S.) (2010/03/04)
    • - Category : TRACO

    TRACO: Brain Cancer

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  • NICHD - 40th Anniversary Scientific Symposium
    • - NICHD (2010/03/04)
    • - Category : Conferences
    NICHD - 40th Anniversary Scientific Symposium

    NICHD - 40th Anniversary Scientific Symposium

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  • 13th National Child Support Enforcement Training Conference Agenda (Day 1)
    • - Federal Office of Child Support Enforcement (2010/03/04)
    • - Category : Conferences
    The goals of the conference are to improve the effectiveness of the CSE program and its partnering programs and to encourage professionals in these areas to look beyond what has been done in the past and embrace successful, although perhaps unfamiliar, ideas and practices that work for our children.

    Please send questions and comments to
    Live Event Feedback Form


    For more information, visit
    13th National CSE Training Conference

    13th National Child Support Enforcement Training Conference Agenda (Day 1)

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  • Neuroplasticity and Cellular Resilience in Bipolar Disorder
    • - Husseini K. Manji, NIMH (2010/03/04)
    • - Category : Mitochondria
    The Mitochondria Interest Group (MIG) is an Inter-Institute Interest Group at the National Institutes of Health (NIH), with members from NIH and from around the world! MIG is concerned with all aspects of the mitochondrion and diseases in which the mitochondrion is involved.

    For more information, visit the
    Mitochondria Interest Group (MIG)

    Neuroplasticity and Cellular Resilience in Bipolar Disorder

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  • TRACO: Cancer Pathophysiology
    • - Moody, Terry W.
      National Institutes of Health (U.S.) (2010/03/04)
    • - Category : TRACO

    TRACO: Cancer Pathophysiology

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  • Advanced Directives: Helping Your Patients and Research Subjects Plan Ahead
    • - Danis, Marion.
      National Institutes of Health (U.S.) (2010/03/04)
    • - Category : Clinical Center Grand Rounds

    Advanced Directives: Helping Your Patients and Research Subjects Plan Ahead

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