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  • NIH VideoCast - Controlling Basal TCR Signaling and its Threshold
    • - Arthur Weiss, M.D., Ph.D.; Ephraim P. Engleman Distinguished Professor; Investigator, Howard Hughes Medical Institute, University of California, San Francisco (2016/01/09)
    • - Category : Immunology
    Immunology Interest Group

    Pr. Art Weiss from the University of California, San Francisco and the HHMI has been a leader in the field of immunoreceptor-mediated signaling for three decades. He and his colleagues have produced a series of outstanding and influential studies teaching us much about how the T cell antigen receptor (TCR) is coupled to downstream signaling events. His major advances include the discovery of the protein tyrosine kinase, ZAP-70, the interaction of this kinase with another tyrosine kinase, Lck, at the onset of TCR signaling, the role of critical tyrosine phosphatases such as CD45 and influential structural studies of ZAP-70. He has been a clinician as well for many years and a number of his studies impact on our understanding of immunodeficiency and autoimmunity. He has mentored a number of outstanding students and fellows who themselves have become leaders in the field. Art Weiss has served as President of the AAI and has received multiple honors including membership in the National Academy of Science and the Institute of Medicine. In this IIG seminar, Dr Weiss will discuss the mechanisms that control basal and inducible signaling by the TCR. Signaling by the TCR involves the regulation of Src and Syk kinases. The control of these kinases is critical for homeostasis and for setting a threshold for responsiveness. The importance of auto-inhibition of the Syk family kinase ZAP-70 will be highlighted by an autoimmune disease that results from mutations in ZAP-70 that impair its auto-inhibition. The critical role of proper regulation of Src family kinases by the CD45 receptor-like protein tyrosine phosphatase and the Csk kinase to establish basal signaling and setting the threshold for TCR signaling will be highlighted. Pr. Weiss` seminars are always data and insight-rich, and he is an excellent speaker. Please attend Pr. Weiss？？？ talk, the first IIG Seminar of 2016.

    NIH VideoCast - Controlling Basal TCR Signaling and its Threshold

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  • NIH VideoCast - Principles of Clinical Pharmacology ~ SPECIAL LECTURE: P-glycoprotein and Drug Transport
    • - Dr. Michael Gottesman, NIH and Dr. Matthew Hall, NIH (2016/01/09)
    • - Category : Principles of Clinical Pharmacology
    The "Principles of Clinical Pharmacology" course is a weekly lecture series covering the fundamentals of clinical pharmacology as a translational scientific discipline focused on rational drug development and utilization in therapeutics. The course is offered annually at the NIH Clinical Center and runs from September through April.

    NIH VideoCast - Principles of Clinical Pharmacology ~ SPECIAL LECTURE: P-glycoprotein and Drug Transport

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  • NIH VideoCast - Introduction to the Principles and Practice of Clinical Research (IPPCR) 2016: Ethical Principles in Clinical Research
    • - Christine Grady, R.N., Ph.D., NIH (2016/01/07)
    • - Category : IPPCR
    The Introduction to the Principles and Practice of Clinical Research (IPPCR) is a course to train participants on how to effectively conduct clinical research. The course focuses on the spectrum of clinical research and the research process by highlighting epidemiologic methods, study design, protocol preparation, patient monitoring, quality assurance, and Food and Drug Administration (FDA) issues.

    For more information go to http://clinicalcenter.nih.gov/training/training/ippcr1.html

    NIH VideoCast - Introduction to the Principles and Practice of Clinical Research (IPPCR) 2016: Ethical Principles in Clinical Research

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  • NIH VideoCast - Demystifying Medicine 2016: The Age of Insight: The Quest to Understand the Unconscious in Portraiture Art, Mind and Brain from Vienna 1900 to the Present
    • - Eric R. Kandel, M.D., University Professor at Columbia University; Kavli Professor and Director, Kavli Institute for Brain Science; Co-Director, Mortimer B. Zuckerman Mind Brain Behavior Institute; and a Senior Investigator at the Howard Hughes Medical Institute (2016/01/07)
    • - Category : Demystifying Medicine
    Demystifying Medicine is an annual course from January to May designed to help bridge the gap between advances in biology and their application to major human diseases. The course includes presentation of patients, pathology, diagnosis, and therapy in the context of major disease problems and current research, primarily directed toward Ph.D. students, fellows, and staff. All are invited.

    Kandel`s lecture title is based on his most recent book of the same name which explores the interaction of artists, writers, physicians, and scientists in the salons of turn-of-the-century Vienna that gave birth to a new way of thinking about the mind. The book won the Bruno-Kreisky Award in Literature, Austria`s highest literary award.

    Kandel trained at the NIH in neurobiology in the late 1950s as well as in psychiatry at Harvard Medical School. He joined the faculty of the College of Physicians and Surgeons at Columbia University in 1974 as the founding director of the Center for Neurobiology and Behavior. In addition, Kandel organized the neuroscience curriculum at Columbia University.

    For more information go to https://demystifyingmedicine.od.nih.gov

    NIH VideoCast - Demystifying Medicine 2016: The Age of Insight: The Quest to Understand the Unconscious in Portraiture Art, Mind and Brain from Vienna 1900 to the Present

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  • NIH VideoCast - Pulse Trains to Percepts: The Challenge of Creating a Perceptually Intelligible World with Sight Recovery Technologies
    • - Ione Fine, Ph.D., University of Washington (2016/01/06)
    • - Category : Neuroscience
    NIH Neuroscience Seminar Series

    Dr. Fine？？？s goal is to understand the mechanisms of plasticity in the human brain by linking changes in function to changes in neuroanatomical structure. They currently study the effects of human visual deprivation using a conjunction of ？？？state-of-the-art？？？ imaging techniques including BOLD imaging, magnetic resonance spectroscopy and high resolution structural imaging.

    While the effects of visual deprivation have been well studied in animal models, much less is known about the effects of blindness on human early visual pathways. They think this is an interesting scientific question for two reasons. First, a deeper understanding of the effects of blindness will prove increasingly important as new sight restoration procedures (such as retinal prosthetic implants, epithelial stem cell replacements, gene therapies and retinal transplants) become available over the next few decades. Second, blindness due to peripheral causes is an excellent model system for understanding prenatal, postnatal and adult cortical plasticity.

    NIH VideoCast - Pulse Trains to Percepts: The Challenge of Creating a Perceptually Intelligible World with Sight Recovery Technologies

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  • NIH VideoCast - Regulation of Lysosomal Function by Organelle Sodium and Potassium Channels
    • - Dejian Ren, Ph.D., University of Pennsylvania (2016/01/05)
    • - Category : Neuroscience
    NIH Neuroscience Seminar Series

    Cellular excitability influences essentially every aspect of life, from fertilization to breathing and heart beating. The major interests of Dr. Ren？？？s lab concern the regulation of cellular excitability, neuronal network activity and animal behavior by ion channels, G-protein coupled receptors, tyrosine kinases and calcium signaling. A recent focus in the lab is to study the molecular mechanisms of neuronal excitability control by extracelular ions and peptide neurotransmitters. Significant changes in extracellular Ca2+ concentrations ([Ca2+]e) can happen in certain brain areas during physiological and pathological conditions such as seizures and brain ischemia. They are interested in understanding at the molecular level how neurons sense the [Ca2+]e changes, how the information is transmitted to the intracellular second messenger system, and how neuronal circuit function is affected by the signaling. Numerous neuropeptides are used by the nervous systems as chemical signals to regulate physiological processes such as feeding, rewarding, pain sensation, arousal and wakefulness. They are interested in how several neuropeptides influence the electrical properties of individual neurons in various brain regions and spinal cord. Along this line, they discovered a novel ion channel activation mechanism by G-protein coupled receptors: it is independent of G-protein activation but requires the Src family of tyrosine kinases and two largely uncharacterized proteins UNC79 and UNC80. Current efforts in this project focus on uncovering how the receptor activation is coupled to channel opening and how such signaling events contribute to the intrinsic properties of neurons under physiological and pathophysiological conditions.

    Another area of research in the lab concerns rhythm generation. All animals display long-period rhythmic behaviors such as circadian rhythm (~ 24 hours), as well as ones with shorter periods such as locomotion, heart beating, and breathing (milliseconds to seconds). They are interested in the molecular mechanisms underlying the generation and modulation of the "short-period" rhythms. They use an integrative approach to study the physiological problems. At the molecular level, they use molecular biology and protein chemistry to study channel proteins and their associated partners. They use electrophysiology methods to record the electrical activities from a single molecule (single channel recording), a whole cell, or a nerve bundle. At the cellular level, they use high-speed fluorescence confocal microscopy to image dynamics of ions and protein molecules inside the cells. At the systems level, they modify the genomes of animals and study the consequences of such modifications on whole organism physiology and behavior.

    NIH VideoCast - Regulation of Lysosomal Function by Organelle Sodium and Potassium Channels

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  • NIH VideoCast - Principles of Pharmacology ~ Equilibrative and Concentrative Drug Transport
    • - Dr. Joseph Ware, NIH (2015/12/23)
    • - Category : Principles of Clinical Pharmacology
    The "Principles of Clinical Pharmacology" course is a weekly lecture series covering the fundamentals of clinical pharmacology as a translational scientific discipline focused on rational drug development and utilization in therapeutics. The course is offered annually at the NIH Clinical Center and runs from September through April.

    NIH VideoCast - Principles of Pharmacology ~ Equilibrative and Concentrative Drug Transport

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  • NIH VideoCast - Neuronal Ensembles in Learned Behaviors in Addiction Research
    • - Bruce Thomas Hope, Ph.D., Investigator, Chief, Neuronal Ensembles in Drug Addiction, NIDA, NIH (2015/12/23)
    • - Category : NIH Director`s Seminars
    Director`s Seminar Series

    Learned associations between drugs and environment play an important role in addiction and are thought to be encoded within specific patterns of sparsely distributed neurons called neuronal ensembles that are selected by drug- and environment-related cues. Similar neuronal ensembles are thought to mediate most learned behaviors. Until recently, nearly all studies of learning-specific neural mechanisms assessed neuroadaptations and mechanisms found in whole brain areas or cell types regardless of whether these neurons were activated or not during behavior. To address this problem, Dr. Hope pioneered the development of technologies and transgenic rat systems for identifying, examining, and manipulating Fos-expressing ensembles in addiction research, including the disruption of highly specific memories in conditioned drug behaviors. These studies open up the possibility of disrupting specific memories in addiction and other learning-based disorders in humans.

    NIH VideoCast - Neuronal Ensembles in Learned Behaviors in Addiction Research

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  • NIH VideoCast - Insights into DNA Damage Response Signaling from an Oncovirus
    • - Sumita Bhaduri-McIntosh, M.D., Ph.D., Pediatric Infectious Diseases & Molecular Genetics and Microbiology, SUNY, Stony Brook, NY (2015/12/22)
    • - Category : DNA Repair
    DNA Repair Interest group

    Acrobat Slides

    NIH VideoCast - Insights into DNA Damage Response Signaling from an Oncovirus

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  • NIH VideoCast - CC Grand Rounds: (1) Familial Non-medullary Thyroid Cancer and (2) Back to the Future: Repurposing Mithramycin for Cancer Therapy
    • - (1) Electron Kebebew, MD, Chief, Endocrine Oncology Branch, and Head, Cancer Genetics/Genomics Section, Center for Cancer Research, NCI, NIH and (2) David Schrump, MD, Head, Thoracic Oncology Section and Co-Chief, Thoracic and Gastrointestinal Oncology Branch, Center for Cancer Research, NCI, NIH (2015/12/22)
    • - Category : Clinical Center Grand Rounds
    Grand Rounds: Familial Non-medullary Thyroid Cancer and Back to the Future: Repurposing Mithramycin for Cancer Therapy

    For more information go to http://www.cc.nih.gov/about/news/grcurrent.html

    NIH VideoCast - CC Grand Rounds: (1) Familial Non-medullary Thyroid Cancer and (2) Back to the Future: Repurposing Mithramycin for Cancer Therapy

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  • NIH VideoCast - Flag Promotion Ceremony Honoring Admiral Richard W. Childs
    • - Admiral Richard W. Childs, M.D., United States Public Health Service Commissioned Corps (2015/12/22)
    • - Category : Special
    This is the formal ？？？Flag Promotion Ceremony？？？ honoring Admiral Richard W. Childs, M.D. As the senior ranking officers in the Commissioned Corps, flag officers exemplify the core values for which Commissioned Officers of the United States Public Health Service (US-PHS) are known. They provide executive level leadership within the Department of Health and Human Services and to the Agencies to which they are assigned. US-PHS flag officers also carry the title of Assistant Surgeon General and, as such, they are relied on by the United States Surgeon General and the Corps to support special initiatives and exhibit the highest caliber of public health leadership.

    For more information go to http://www.nhlbi.nih.gov/research/intramural/researchers/pi/childs-richard/

    NIH VideoCast - Flag Promotion Ceremony Honoring Admiral Richard W. Childs

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  • NIH VideoCast - Using Data to Save More Lives and Drive Progress Towards the Control of the HIV Epidemic
    • - Deborah L. Birx, M.D,. U.S. Global AIDS Coordinator & U.S. Special Representative for Global Health Diplomacy U.S. Department of State (2015/12/18)
    • - Category : Joseph J. Kinyoun - Infection and Immunity
    Ambassador-at-Large Dr. Deborah L. Birx, a renowned HIV/AIDS expert, will deliver the 2015 Joseph J. Kinyoun Memorial Lecture. She will discuss how data are being leveraged to save lives and drive progress toward sustained control of the global HIV/AIDS pandemic. Birx is the U.S. Global AIDS Coordinator and U.S. Special Representative for Global Health Diplomacy. She oversees implementation of the U.S. President？？？s Emergency Plan for AIDS Relief (PEPFAR), the largest commitment to combat a single disease by any nation in history. PEPFAR collects and analyzes data to understand health care service cost, quality and achievements at community care sites around the globe. Birx will describe how use of these detailed data has been critical for understanding local HIV prevalence, determining the quality and cost of services and defining key gaps. She will discuss how PEPFAR is working with host countries to use these data to refocus programs for maximal impact. Over the past 30 years, Birx has focused on HIV/AIDS immunology, vaccine research and global health. As Director of the U.S. Military HIV Research Program, she helped lead the landmark RV144 HIV vaccine trial in Thailand, which provided the first evidence that a vaccine could provide protection against HIV infection. From 2005 to 2014, as Director of the Division of Global HIV/AIDS at CDC, Birx led the agency？？？s implementation of PEPFAR programs around the world. Since 1979, NIAID has hosted an annual public lecture in honor of Dr. Joseph J. Kinyoun, a pioneer of modern scientific research. Kinyoun founded the Laboratory of Hygiene, the forerunner of NIH, in 1887, launching a new era of scientific study of infectious diseases.

    NIH VideoCast - Using Data to Save More Lives and Drive Progress Towards the Control of the HIV Epidemic

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  • NIH VideoCast - Introduction to the Principles and Practice of Clinical Research (IPPCR) 2015: Legal Issues in Clinical Research
    • - Carrie Kennedy, J.D., R.N., Esq., Senior Attorney, HHS Office of the General Counsel, Public Health Division, National Institutes of Health Branch (2015/12/18)
    • - Category : IPPCR
    The Introduction to the Principles and Practice of Clinical Research (IPPCR) is a course to train participants on how to effectively conduct clinical research. The course focuses on the spectrum of clinical research and the research process by highlighting epidemiologic methods, study design, protocol preparation, patient monitoring, quality assurance, and Food and Drug Administration (FDA) issues.

    For more information go to http://clinicalcenter.nih.gov/training/training/ippcr1.html

    NIH VideoCast - Introduction to the Principles and Practice of Clinical Research (IPPCR) 2015: Legal Issues in Clinical Research

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  • NIH VideoCast - Alzheimer`s Disease: A woman`s health issue, a woman`s health cure
    • - Roberta Diaz Brinton, Ph.D., Vanderveen Chair in Therapeutic Discovery and Development, and Professor of Pharmacology and Pharmaceutical Sciences, Biomedical Engineering and Neurology, University of Southern California (2015/12/18)
    • - Category : WALS - Wednesday Afternoon Lectures
    Wednesday Afternoon Lecture Series

    Research in the Brinton laboratory is focused on discovery of mechanisms by which the aging brain develops late onset Alzheimer？？？s and therapeutics that target these mechanisms to prevent, delay and treat the disease. Our research spans basic mechanistic discovery to FDA IND enabling translational analyses to Phase 1 and 2 clinical trials. Our NIA sponsored discovery research has investigated the neuro-systems-biology of aging in the sex with greatest risk of developing late onset Alzheimer？？？s. Outcomes of our discovery research indicate that ovarian steroids are fundamental regulators of the bioenergetic system of the brain. Further, the aging female brain undergoes a bioenergetic transition that leads to a switch from a glucose dependent brain to an adaptive reliance upon an alternative fuel, ketone bodies, consistent with a starvation response. Fundamental insights that have emerged from these programs of research indicate that the aging brain is remarkably dynamic and adaptive. However, these adaptations may prove to be a key driver of risk for late onset Alzheimer？？？s disease.

    For more information go to https://oir.nih.gov/wals

    NIH VideoCast - Alzheimer`s Disease: A woman`s health issue, a woman`s health cure

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  • NIH VideoCast - Coupling Single-Cell RNA-seq with Tracking of Regulatory Determinants Reveals Rare Hematopoietic Transition States
    • - H. Leighton Grimes, Ph.D.; Professor, Division of Immunobiology, Cincinnati Childrens Hospital Medical Center (2015/12/18)
    • - Category : Immunology
    Immunology Interest Group

    Dr. Grimes received his Ph.D. in Molecular Pathology and Immunology studying gene regulation with Maureen Goodenow at the University of Florida, then joined Philip Tsichlis at Fox Chase Cancer Center, cloning novel genes activated by insertion mutagenesis (e.g. Akt, Tpl2). He has a broad background in hematopoiesis, molecular biology, and molecular oncology including modeling of hematopoiesis, myelopoiesis and leukemia. His work on the Growth factor independent-1 (Gfi1) transcriptional repressor protein has spanned the initial identification of Gfi1 in a model of leukemia and the role of Gfi1 in normal myeloid biology, to the identification of GFI1 mutations in patients with severe congenital neutropenia (SCN) and non-immune chronic idiopathic neutropenia of adults (NI-CINA). His work bridges normal hematopoietic development and innate immune action with marrow failure and transformation. His lab does it all! Don？？？t miss this talk by a dynamic speaker!

    NIH VideoCast - Coupling Single-Cell RNA-seq with Tracking of Regulatory Determinants Reveals Rare Hematopoietic Transition States

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  • NIH VideoCast - Common Fund High-Risk, High-Reward Research Symposium (Day 3)
    • - NIH (2015/12/16)
    • - Category : Conferences
    The NIH Common Fund is pleased to present the 2015 High-Risk, High-Reward Research Symposium. The Symposium will bring together recipients of the Pioneer, New Innovator, Transformative Research, and Early Independence Awards to share groundbreaking research and discoveries.

    For more information go to https://commonfund.nih.gov/highrisk/symposia15

    NIH VideoCast - Common Fund High-Risk, High-Reward Research Symposium (Day 3)

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  • NIH VideoCast - Advances in Pediatric Trauma and Critical Illness Research: Building the Field, Advancing the Science
    • - NICHD, NIH (2015/12/16)
    • - Category : Conferences
    Within the United States, more than 9,000 children die every year due to unintentional injury, and more than 5,500 die from an intentional or violence related injury. More than 9 million are treated for injuries in emergency departments, with many more exposed to physical or psychological trauma. In addition, nearly 500,000 children will receive intensive care for life-threatening illness or injury.

    The global impact of childhood trauma and critical illness is far-reaching, extending from profound effects on the child and entire family, to the community and schools, to society at large. Through support of life-saving research, education, training, and collaboration, PTCIB aims to achieve its mission "to prevent and reduce all forms of childhood trauma, injury, and critical illness to enhance healthy outcomes" for children and their families.

    This scientific meeting will allow PTCIB to share and discuss its research mission and goals with the broader scientific community. Discussions will include (but are not limited to) pediatric critical care research, reducing pediatric injury and trauma, and the continuum of care.

    NIH VideoCast - Advances in Pediatric Trauma and Critical Illness Research: Building the Field, Advancing the Science

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  • NIH VideoCast - Principles of Clinical Pharmacology ~ Drug Interations
    • - Dr. Sarah Robertson, Vertex Pharmaceuticals (2015/12/16)
    • - Category : Principles of Clinical Pharmacology
    The "Principles of Clinical Pharmacology" course is a weekly lecture series covering the fundamentals of clinical pharmacology as a translational scientific discipline focused on rational drug development and utilization in therapeutics. The course is offered annually at the NIH Clinical Center and runs from September through April.

    NIH VideoCast - Principles of Clinical Pharmacology ~ Drug Interations

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  • NIH VideoCast - Introduction to the Principles and Practice of Clinical Research (IPPCR) 2015: Module I Summary and Study Examples
    • - Laura Lee Johnson, Ph.D., FDA (2015/12/16)
    • - Category : IPPCR
    The Introduction to the Principles and Practice of Clinical Research (IPPCR) is a course to train participants on how to effectively conduct clinical research. The course focuses on the spectrum of clinical research and the research process by highlighting epidemiologic methods, study design, protocol preparation, patient monitoring, quality assurance, and Food and Drug Administration (FDA) issues.

    For more information go to http://clinicalcenter.nih.gov/training/training/ippcr1.html

    NIH VideoCast - Introduction to the Principles and Practice of Clinical Research (IPPCR) 2015: Module I Summary and Study Examples

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  • NIH VideoCast - Secretary`s Advisory Committee on Human Research Protections - December 2015 (Day 2)
    • - HHS (2015/12/15)
    • - Category : Advisory Board Meetings and Workshops
    This is a SACHRP meeting; SACHRP is a Federal advisory committee advising the Secretary on matters pertaining to human research protections. The agenda will focus on discussion of recommendations to the recently issued NPRM. Office for Human Research Protections (OHRP)

    For more information go to http://www.hhs.gov/ohrp/sachrp/index.html

    NIH VideoCast - Secretary`s Advisory Committee on Human Research Protections - December 2015 (Day 2)

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