KOSEN 한인과학기술자네트워크

DNA Repair Interest Group

Acrobat Slides http://videocast.nih.gov/pdf/dnarig102715.pdf

NIH Director？？？s Wednesday Afternoon Lecture Series

Dr. Fraser`s current research interests are focused oncharacterization of the structure and function of the microbial communitiesthat are found in the human environment, as part of the NIH-funded HumanMicrobiome Project, including projects specifically focused on obesity,metabolic syndrome, inflammatory bowel disease, the interactions between thehuman immune response and the gut microbiome, and the impact of probiotics onthe structure and function of the intestinal microbiome. 

About the annual Rolla E. Dyer lecture:

The annual Rolla E. Dyer Lecture features aninternationally renowned researcher who has contributed substantially to themedical as well as the biological knowledge of infectious diseases. Establishedin 1950, the lecture series honors former NIH director Dr. Dyer, who was anoted authority on infectious diseases.

For more information go to https://oir.nih.gov/wals

NIH Director？？？s Wednesday Afternoon Lecture

Primary cilia are microtubule-based organelles that arenow known to be present on nearly all differentiated cell types in metazoans.Cilia house signaling molecules that transduce environmental cues and regulatecellular homeostasis and organismal development. Disruption of cilia structureor function is linked with a plethora of diseases termed ciliopathies, many ofwhich are characterized by sensory defects. Despite increased focus on thiscritically important cellular structure, the mechanisms that link ciliogenesisand cilia structure to cilia-based signaling remain to be fully elucidated. Thenematode C. elegans provides an excellent model for the study of ciliogenesisand sensory signaling. Cilia are present only on sensory neurons in C. elegans,and as in other organisms, are essential for the unique functions of theseneuron types. In particular, many sensory neurons in C. elegans exhibitremarkably complex cilia structures, providing an excellent system in which toexplore the conserved pathways that couple the generation of specialized ciliamorphology to unique cellular and signaling functions. In her presentation, Dr.Sengupta will describe recent and ongoing work in the lab on mechanisms thatgenerate and maintain cilia structural diversity in C. elegans, and discuss thecomplex interplay between cilia architecture and sensory neuron function.

Immunology Interest Group

Dr. Prussin is currently Chair of the Board of Directors of the American Board of Allergy and Immunology. Prior to July 2015, Dr. Prussin was a Staff Clinician, Clinical Investigator, and Associate Director of the NIH Allergy and Immunology Fellowship Training Program, within the Laboratory of Allergic Diseases, NIAID. He received his M.D. and his internal medicine training at the Keck School of Medicine of the University of Southern California (USC). He came to NIH for a postdoctoral fellowship with Ron Schwartz, after which he completed his Allergy and Immunology Clinical Fellowship at NIH working with Dean Metcalfe. Dr. Prussin was one of the first investigators to apply intracellular cytokine staining to human disease in work demonstrating the existence of human Th1 and Th2 cells directly ex vivo. He uses a translational approach to examine important immunological questions using human disease as a model system to interrogate the biology of human allergic effector cells, most notably Th2 cells, basophils, and mast cells. Dr. Prussin？？？s work is notable for identifying Fc？？RI on dendritic cell subpopulations and demonstrating its modulation by anti-IgE treatment. His recent work has resulted in a series of papers focusing on human Th2 cell heterogeneity. This work establishes the existence of discreet Th2 subpopulations, characterizes their function, defines specific phenotypic markers, and identifies the mTORC1 pathway as a potential means to target pathogenic effector Th2 cells. Calman is an engaging speaker whose translational approach examines fundamental immunological questions that are widely applicable. Don？？？t miss his exciting and interesting talk!