KOSEN 한인과학기술자네트워크

>Heparin의 단위 표현에 있어서 어떤 곳은 IU/ml로 표기가 >되어 있는 곳도 있고, unit/ml로 표기 되어있는 곳도 있습니다 >IU/ml 과 unit/ml과 같은 걸까요?? > >올라와 있는 자료에서 보면 답변이 많이 있습니다만, >이해하기가 어려워 글을 올립니다 >답변 부탁드립니다^-^ > IU 는 international unit (국제 단위로 번역되고요) 사람들이 보통 단위(unit)로 줄여서 쓰기도합니다. IU는 생리활성을 기초로 만든 단위로서 생리활성 물질별 IU 해당하는 질량은 상이합니다. Heparin은 1단위 즉 1IU 은 7.7 마이크로 그램입니다. 즉( 약 124 IU/mg) 부근입니다. wikipedia 정의 In pharmacology, the International Unit is a unit of measurement for the amount of a substance, based on measured biological activity or effect. "International Unit" is abbreviated as IU, or as UI from the French unit？ internationale, or as IE from the German Internationale Einheit. The unit is used for vitamins, hormones, some medications, vaccines, blood products, and similar biologically active substances. Despite its name, the IU is not part of the International System of Units used in physics and chemistry. The precise definition of one IU differs from substance to substance and is established by international agreement for each substance. There is no equivalence among different substances; for instance, one IU of vitamin E does not contain the same number of milligrams as one IU of vitamin A. To define an IU of a substance, the Committee on Biological Standardization of the World Health Organization provides a reference preparation of the substance, arbitrarily sets the number of IUs contained in that preparation, and specifies a biological procedure to compare other preparations of that substance to the reference preparation. The goal in setting the standard is that different preparations with the same biological effect will contain the same number of IUs. For some substances, the equivalent mass of one IU is later established. If that happens, the former IU definition for that substance is officially abandoned, in favor of a newly established weight. However, the unit count often remains in use nevertheless, because it is convenient. For example, vitamin E exists in a number of different forms, all having different biological activities. Rather than specifying the precise type and mass of vitamin E in a preparation, for the purposes of pharmacology it is sufficient, simply, to specify the number of IUs of vitamin E. The mass equivalents of 1 IU for selected substances are: Insulin: 1 IU is the biological equivalent of 45.5 μg pure crystalline insulin (1/22 mg exactly) Vitamin A: 1 IU is the biological equivalent of 0.3 μg retinol, or of 0.6 μg beta-carotene Vitamin C: 1 IU is 50 μg L-ascorbic acid Vitamin D: 1 IU is the biological equivalent of 0.025 μg cholecalciferol/ergocalciferol Vitamin E: 1 IU is the biological equivalent of 2/3 mg (0.667) d-alpha-tocopherol, or of 1 mg of dl-alpha-tocopherol acetate