Research Areas: 1. Regulation of T helper cell differentiation by T-bet : Differentiation of T helper progenitors to Th1 or Th2 effector cells requires the action of the critical transcription factors, T-bet. T-bet reveals triple separable functions for Th1 cell differentiation through the protein modification. The regulation of T-bet expression, and modification can be critical for immune disorders such as asthma, or autoimmune diseases. We studies on functional mechanism of T-bet and its applications in human immune disorders. 2. Regulation of mesenchymal stem cell differentiation by TAZ. : Mesenchymal stem cells are required for the repair of loss of tissues or organs, particularly bone, cartilage, adipose and muscle. TAZ is known to be a critical regulator of mesenchymal stem cell differentiation into osteoblasts and adipocytes. We are interested in novel function and functional mechanism of TAZ and applying TAZ in related diseases like osteoporosis, bone and cartilage loss, obese and muscle atrophy.
#T helper 세포 분화 조절 신호전달기전 연구
#중간엽줄기세포 분화 조절 유전자 TAZ 기능 및 기전연구
#질병 관련 T 세포 중심 면역 활성 연구
#TAZ 유전자 기능과 대사성 질환 및 근골격계 질환 연관성 연구
#면역계와 근골격계 신호전달 네트워크 연구
#유전자를 target으로 질환 치료제 후보물질 발굴 연구
