peroxiredoxin (Prx)의 기능연구
- hyperoxidation and retroreduction of Prx isotypes in
oxidative stressed cells or tissues (proteome analysis)
cultured cells stimulated by ligand (redox signal transduction)
disease models
cancer cells
- regulation of Prx activity
inactivation by hyperoxidation
inactivation, reactivation mechanism by C-terminal truncation
growth factor and cytokine signaling (using adenovirus system)
cell cycle dependency
- screening of Prx binding proteins using immobilized Prx affinity column and proteome analysis technique
redox proteome 분석 (using 2D-overlay assay, BIAM-labeled 2D-PAGE & MALDI-TOF, ESI-MS/MS)
- analysis of redox-modified proteins under oxidative stressed, γ-irradiated, ligand stimulated cells
- analysis of redox-modified proteins in cancerous cells or tissues
- Ab preparation of redox proteome
국가
대한민국
소속기관
전남대학교 (학교)
연락처
책임자
채호준 hzchae@chonnam.ac.kr