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  • (1) Insights Into the Role of Inflammation in Post-Traumatic Stress Disorder (PTSD) With and Without Depression (2) An Inflammatory Profile for Stroke Diagnosis & Outcome Prediction
    • - Jessica M. Gill, NINR, NIH and Taura L. Barr, NINR, NIH (2010/11/18)
    • - Category : Clinical Center Grand Rounds
    NIH Clinical Center Grand Rounds

    (1) Jessica M. Gill, PhD, RN, Assistant Clinical Investigator, NINR

    (2) Taura L. Barr, PhD, RN, Special Volunteer, Tissue Injury Unit, NINR

    (1) Insights Into the Role of Inflammation in Post-Traumatic Stress Disorder (PTSD) With and Without Depression (2) An Inflammatory Profile for Stroke Diagnosis & Outcome Prediction

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  • A New Virus as a Culprit in Human Cancer
    • - Yuan Chang, M.D., University of Pittsburgh (2010/11/18)
    • - Category : Wednesday Afternoon Lectures
    Merkel cell polyomavirus (MCV) is a recently discovered human virus found by digital transcriptome subtraction (DTS). The virus is clonally integrated in approximately 80% of Merkel cell carcinomas (MCC), a rare but aggressive skin cancer. Similar to other polyomaviruses, MCV has a ~5,200 bp genome with a non-coding region which regulates expression of early and late genes. The early region encodes for three T antigen isoforms: Large T (LT), small T (sT), 57 kT. These proteins contain N-terminal RB-binding, DnaJ, and PP2A interacting motifs; the LT isoform further contains C-terminal origin binding and helicase domains required for viral replication. The majority of MCV-positive MCC tumors and cell lines express truncated LT proteins which lack replication function yet retain N-terminal regulatory functions. We have develop monoclonal antibodies which show T antigen (TAg) expression in MCC tumor cells, the importance of which is underscored by TAg knock-down experiments that abolish growth in MCV-positive cell lines. This finding further strengthens the etiologic role of MCV in the MCV-positive subset of MCC tumors. Although MCV infection is common in North America, MCC is relatively uncommon and our studies suggest that this may be due to the requirement of multiple molecular events including integration of viral genome and TAg truncating mutations in a susceptible host.

    The NIH Directors Wednesday Afternoon Lecture Series includes weekly scientific talks by some of the top researchers in the biomedical sciences worldwide.

    A New Virus as a Culprit in Human Cancer

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  • Macrophages, lymphatics, and antigens in adipose tissue
    • - Gwendalyn Randolph (2010/11/18)
    • - Category : Immunology
    The Immunology Interest Group

    Macrophages, lymphatics, and antigens in adipose tissue

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  • NCI Directors Awards - 2010
    • - Sue Kiser, NCI Office of the Director (2010/11/18)
    • - Category : Special
    Since the National Cancer Act was passed by Congress in 1971, making cancer research a national priority, NCI employee efforts have led to significant progress in cancer detection, diagnosis, prevention, treatment, and survivorship. Each year at the NCI Director？？？s Award Ceremony, we recognize the outstanding contributions of our colleagues that aid in the continued advancement of this progress.

    NCI Directors Awards - 2010

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  • Fifth Annual Philip S. Chen, Jr. Lecture - Human Retroviruses: Perspectives from the Past, Prospects for the Future
    • - Dr. Robert C. Gallo, University of Maryland School of Medicine (2010/11/18)
    • - Category : Philip S. Chen
    Phlip S. Chen, Jr., Ph.D., Distinguished Lecture on Innovation and Technology Transfer

    In commemoration of the 25th anniversary of the HIV-1 diagnostic kit, Dr. Robert C. Gallo will present ？？？Human Retroviruses: Perspectives from the Past, Prospects for the Future.？？？ Dr. Gallo is Director and Professor, Institute of Human Virology of the University of Maryland School of Medicine.

    Fifth Annual Philip S. Chen, Jr. Lecture - Human Retroviruses: Perspectives from the Past, Prospects for the Future

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  • The 12th Annual Norman P Salzman Memorial Award & Symposium in Virology
    • - B. Hahn, R. Silverman, K. Berns and many young virologists (2010/11/18)
    • - Category : Conferences
    The event is a virology symposium in Natcher to honor the memory of Norman Salzman. It is sponsored by the NIH Virology Interest Group

    The 12th Annual Norman P Salzman Memorial Award & Symposium in Virology

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  • NIH R&D Contract Solicitation, Review and Selection Process (HHS Only)
    • - Chuck Selden (2010/11/18)
    • - Category : ESA (HHS Only)
    Detailed view of and ？？？How To？？？ for review of NIH Extramural R&D contracts; plus, how to plan a solicitation, addressing severable and non-severable contracts and other funding mechanism issues; how to write the SOW, RFP and Evaluation Criteria; how to plan a contract peer review meeting; what happens at a contract ？？？technical evaluation？？？ meeting; and how to carry out post review administrative procedures (for the review official and the program official).

    NIH R&D Contract Solicitation, Review and Selection Process (HHS Only)

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  • Beyond Superiority to Placebo: The Legitimacy of Placebo Efficacy
    • - Frank Miller, Clinical Center Department of Clinical Bioethics, NIH (2010/11/18)
    • - Category : NCCAM Lectures
    The Complementary and Integrative Medicine Consult Service Lecture Series Sponsored by NCCAM Provides NIH Clinical Center Staff with Opportunities to Learn more about How the Integration of Various Complementary and Alternative Medicine Treatments Can Affect Approaches in the Research and Practice for Medicine

    Beyond Superiority to Placebo: The Legitimacy of Placebo Efficacy

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  • TRACO: Epidemiology
    • - N. Caporaso (2010/11/18)
    • - Category : TRACO
    For more information, visit
    http://ccr.cancer.gov/careers/traco.asp

    TRACO: Epidemiology

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  • Seventh Annual Interdisciplinary Womens Health Research Symposium
    • - Vivian W. Pinn, M.D. and Alan Guttmacher, M.D. (2010/11/18)
    • - Category : Womens Health
    The National Institutes of Health (NIH) Office of Research on Women？？？s Health (ORWH) will host the Seventh Annual Interdisciplinary Women？？？s Health Research Symposium to showcase research findings from the Building Interdisciplinary Research Careers in Women？？？s Health (BIRCWH) scholars and Specialized Centers of Research (SCOR) on Sex and Gender Factors Affecting Women？？？s Health researchers. In addition, poster abstracts from both programs will be displayed outside Masur Auditorium.

    Vivian W. Pinn, M.D., Associate Director for Research on Women？？？s Health and Director, Office of Research on Women？？？s Health at NIH will provide opening remarks. The keynote speaker will be Alan Guttmacher, M.D., Director of the Eunice Kennedy Shriver National Institute of Child Health and Human Development.

    Seventh Annual Interdisciplinary Womens Health Research Symposium

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  • Tumor Glucose Metabolism: Molecular Underpinnings and Therapeutic Opportunities (NIH Only)
    • - Mark A. Israel, M.D. (2010/11/18)
    • - Category : NCI CCR Grand Rounds (NIH Only)
    Dr. Mark Israel is a Professor of Pediatrics and of Genetics, and the Director of Dartmouth-Hitchcock Norris Cotton Cancer Center. An internationally distinguished cancer physician and translational scientist, he specializes in the molecular and cellular biology of brain tumors. Early in his career, Dr. Israel was recruited to the National Institutes of Health, where he rose to head the Molecular Biology Section in the Pediatric Branch of the National Cancer Institute. He then became the Kathleen M. Plant Distinguished Professor and Director of the Preuss Laboratory of Molecular Neuro-oncology at University of California, San Francisco. In 2001, he was recruited to Dartmouth to assume the leadership of Norris Cotton Cancer Center, which is one of 40 Comprehensive Cancer Centers recognized by the National Cancer Institute for excellence in research, treatment, education, and community outreach. Trained as a pediatric oncologist, Dr. Israel has made promising discoveries on nervous system tumors to benefit children and young adults with cancer. Using these tumors as models, Dr. Israel has advanced understanding of the molecular pathways that coordinate cell development, maturation, and death. He has identified genetic cues that go awry, causing cells to proliferate wildly to produce a tumor. He was the first to show that histologically similar tumors can be genetically distinct, and harnessed these differences to target treatment against certain cancer types. His ground-breaking research has helped pave the way for innovative therapeutic approaches to combat and cure brain tumors and other childhood cancers that once defied treatment, and has helped improve survival for youngsters with aggressive cancers previously considered hopeless. Dr. Israel has authored more than 200 peer-reviewed papers, and he received the Farber Award for outstanding contributions to neuro-oncology. He serves on the Executive Committees of the Association of American Cancer Institutes and the Foundation for Advanced Education in the Sciences, as well as the Scientific Advisory Boards of several foundations and Cancer Centers and the editorial boards of several leading scientific journals. Dr. Israel was elected to the American Academy of Physicians in 2007.

    NCI？？？s Center for Cancer Research (CCR) Grand Rounds is a weekly lecture series addressing current research in clinical and molecular oncology. Speakers are leading national and international researchers and clinicians proposed by members of the CCR Grand Rounds Planning Committee and others within the CCR community and approved by the CCR Office of the Director. Lectures occur every Tuesday from 8:00 to 9:00 a.m. in Lipsett Amphitheater in the Clinical Center building on the NIH campus September through July with exceptions around holidays and major cancer meetings. CME credit available via sign-up sheets in the lecture hall and at designated video-bridge sites only.

    Tumor Glucose Metabolism: Molecular Underpinnings and Therapeutic Opportunities (NIH Only)

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  • Redox Biology: NADPH Oxidases, Imaging
    • - T. Leto and M. Krishna (2010/11/18)
    • - Category : Redox Biology
    For more information, visit
    http://ccr.cancer.gov/careers/courses/rb/

    Redox Biology: NADPH Oxidases, Imaging

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  • NIH American Indian Alaska Native Observance 2010 - Pathways to Health Equity for Indigenous Peoples in Canada
    • - Dr. Malcolm King, Canadian Institutes of Health Research & Jackie Bird, Lakota Indian championship Hoop Dancer (2010/11/18)
    • - Category : Native American
    Program Speaker: Dr. Malcolm King, Scientific Director of the Institute of Aboriginal Peoples Health, Canadian Institutes of Health Research. The topic of his talk will be on the ？？？Pathways to Health Equity for Indigenous People in Canada.？？？ Dr. King completed his PhD in polymer chemistry at McGill University in Montreal, fellowships at the Weizmann Institute of Science in Rehovot, Israel, and the Meakins-Christie Laboratories at McGill University. His areas of research interest include respiratory health issues among the Aboriginal people, health service delivery to vulnerable populations, the interaction of education and health, airborne disease transmission and chronic obstructive lung diseases.

    Cultural Presentation by: Ms. Jackie Bird, is a Lakota Indian, a championship Hoop Dancer, and an absolutely charming performer. She will sing traditional songs in her native language, and perform a traditional form of Native American dance using intricate manipulation of hoops to form images and tell a story to celebrate the heritage of American Indians and Alaska Natives

    NIH American Indian Alaska Native Observance 2010 - Pathways to Health Equity for Indigenous Peoples in Canada

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  • Contemporary Clinical Medicine: Great Teachers: The Eradication of Smallpox: Only the First Chapter
    • - D.A. Henderson, MD, MPH, University of Pittsburgh Medical Center (2010/11/18)
    • - Category : Clinical Center Grand Rounds
    NIH Clinical Center Grand Rounds

    D.A. Henderson, MD, MPH, Distinguished Scholar at the Center for Biosecurity, University of Pittsburgh Medical Center and Professor of Public Health and Medicine, University of Pittsburgh

    Contemporary Clinical Medicine: Great Teachers: The Eradication of Smallpox: Only the First Chapter

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  • Sex Battles in the Brain
    • - Catherine Dulac, Ph.D., Harvard University (2010/11/18)
    • - Category : Wednesday Afternoon Lectures
    The NIH Directors Wednesday Afternoon Lecture Series includes weekly scientific talks by some of the top researchers in the biomedical sciences worldwide.

    Sex Battles in the Brain

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  • Molecular Mechanisms of Leukocyte Migration
    • - Michael Sixt (2010/11/18)
    • - Category : Immunology
    The Immunology Interest Group

    Molecular Mechanisms of Leukocyte Migration

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  • TRACO: RNAi and Lung Cancer
    • - N. Caplen and E. Szabo (2010/11/18)
    • - Category : TRACO
    RNAi and lung cancer For more information, visit
    http://ccr.cancer.gov/careers/traco.asp

    TRACO: RNAi and Lung Cancer

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  • Discovery of the Mechanism That Enables the Provision of Nutrients to Proliferating Cells (NIH Only)
    • - Prof Sir Salvador Moncada, FMedSci, University College London (2010/11/18)
    • - Category : NCI CCR Grand Rounds (NIH Only)
    Salvador Moncada, MD, obtained his PhD in the early 1970s at the Royal College of Surgeons in London, where he contributed to the discovery that aspirin-like drugs inhibit prostaglandin biosynthesis, thus accounting for their analgesic, anti-pyretic and anti-inflammatory actions. In 1975 he joined the Wellcome Research Laboratories where he initiated the work leading to the discovery of the enzyme thromboxane synthase and the vasodilator prostacyclin. This work contributed to the understanding of how low doses of aspirin prevent cardiovascular episodes such as myocardial infarction and stroke. He was also responsible for the identification of nitric oxide as a biological mediator and the elucidation of the metabolic pathway leading to its synthesis. A great deal of the early work on the biological significance of nitric oxide in the cardiovascular system came from his laboratory as well as some fundamental information about the role of nitric oxide in the peripheral and central nervous system and in cancer. In 1996 Prof. Moncada moved to University College London to establish and direct the Wolfson Institute for Biomedical Research. He has continued his research more recently in the areas of mitochondrial biology and cell metabolism where he has made significant contributions. It is at this point when he became interested in glycolysis and made the findings that he is going to discuss this afternoon. Professor Moncada is a Fellow of the Royal Society and a Foreign Associate of the National Academy of Science of the USA and earlier this year he received a Knighthood for his services to Science.

    NCI？？？s Center for Cancer Research (CCR) Grand Rounds is a weekly lecture series addressing current research in clinical and molecular oncology. Speakers are leading national and international researchers and clinicians proposed by members of the CCR Grand Rounds Planning Committee and others within the CCR community and approved by the CCR Office of the Director. Lectures occur every Tuesday from 8:00 to 9:00 a.m. in Lipsett Amphitheater in the Clinical Center building on the NIH campus September through July with exceptions around holidays and major cancer meetings. CME credit available via sign-up sheets in the lecture hall and at designated video-bridge sites only.

    Discovery of the Mechanism That Enables the Provision of Nutrients to Proliferating Cells (NIH Only)

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  • GMAC - X Train Overview (HHS Only)
    • - Linda Katzper, Jen Flach (2010/11/18)
    • - Category : GMAC (HHS Only)
    Have you heard that appointment forms and termination notices will have to be submitted electronically as of January, 2011? Did you know that Agency staff will be reviewing and accepting these appointment using x Train? Come to our overview and find out how institutions create, track and submit their electronic appointments and termination notices. Learn how Agency staff will use X Train to accept appointments and termination notices without a paper process. You will discover the basics of X Train, including logging into Commons; searching for and managing the many aspects of Appointments and Termination Notices; understanding the Trainee Roster; performing a Grant Search or a Person Search, and lots more!

    GMAC - X Train Overview (HHS Only)

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  • History of and Framework for Human Subject Research - Session 1
    • - Ezekiel Emanuel, John Arras and Christine Grady (2010/03/04)
    • - Category : Bioethics
    The Ethical and Regulatory Aspects of Human Subject Research, a course developed for the NIH community by Ezekiel J. Emanuel, MD, PhD, Chair of the Department of Clinnical Bioethics and Christine Grady, PhD, RN, Head of the Section on Human Subject Research in the Department of Clinical Bioethics, is being offered for the fifth year. This course will be of interest to anyone in the NIH community who works with human subjects or who has an interest in human subject research, and this includes support staff, grant administrators, administrators as well as clinical staff.

    Framework for the Ethics of Research with Human Subjects
    Ezekiel Emanuel, M.D., Ph.D., NIH

    Scandals and Tragedies: Beecher, Tuskegee, Willowbrook and the Rest
    John Arras, Ph.D., University of Virginia

    Do the Codes Apply to My Research Protocol? Nuremberg, Helsinki, the Belmont Report, CIOMS, and the Common Rule
    Christine Grady, NIH

    History of and Framework for Human Subject Research - Session 1

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