KOSEN 한인과학기술자네트워크

The cell biology of autophagy and its relevance to human physiology and disease, with a focus on the nervous system

Key papers:

A Ashkenazi, CF Bento, T Ricketts, M Vicinanza, F Siddiqi, M Pavel, F Squitieri, MC Hardenberg, S Imarisio, FM Menzies & DC Rubinsztein (2017) Polyglutamine tracts regulate beclin 1-dependent autophagy. Nature 545:108-111.

M Jimenez-Sanchez, W Lam, M Hannus, B Sönnichsen, S Imarisio, A Fleming, A Tarditi, F Menzies, T Ed Dami, C Xu, E Gonzalez-Couto, G Lazzeroni, F Heitz,  D Diamanti, L Massai, VP Satagopam, G Marconi, C Caramelli, A Nencini, M Andreini, GL Sardone6, NP Caradonna, V Porcari, C Scali, R Schneider, G Pollio, CJ O’Kane, A Caricasole and DC Rubinsztein. siRNA screen identifies QPCT as a druggable target for Huntington’s disease. Nature Chem. Biol. 11, 347-354 (2015).

M Vicinanza, VI Korolchuk, A Ashkenazi, C Puri, FM Menzies, JH Clarke and DC Rubinsztein. PI(5)P regulates autophagosome biogenesis. Mol. Cell 57, 219-234 (2015).

C Puri, M Renna, C Figueira Bento, K Moreau and DC Rubinsztein Diverse autophagosome membrane sources coalesce in recycling endosomes. Cell 154, 1285-1299 (2013).

S Luo, M Garcia-Arencibia, R Zhao, C Puri, PPC Toh, O Sadiq and DC Rubinsztein. Bim inhibits autophagy by recruiting Beclin 1 to microtubules. Mol. Cell 47, 359-370 (2012).

K Moreau, B Ravikumar, M Renna, C Puri, and DC Rubinsztein. Autophagosome precursor maturation requires homotypic fusion. Cell 146, 303-317 (2011).

S Sarkar, VI Korolchuk, M Renna, S Imarisio, A Fleming, A Williams, M Garcia-Arencibia, C Rose, S Luo, BR Underwood, G Kroemer, CJ O’Kane, and DC Rubinsztein Complex inhibitory effects of nitric oxide on autophagy. Mol. Cell 43, 19-32 (2011).

VI Korolchuk, S Saiki, M Lichtenberg, FH Siddiqi, EA Roberts, S Imarisio, L Jahreiss, S Sarkar, M Futter, FM Menzies, CJ O’Kane, V Deretic and DC Rubinsztein Lysosomal positioning coordinates cellular nutrient responses. Nature Cell Biol. 13, 453-460 (2011).

B Ravikumar, K Moreau, L Jahreiss, C Puri and DC Rubinsztein. Plasma membrane contributes to the formation of pre-autophagosomal structures. Nature Cell Biol. 12:747-757 (2010).

AR Winslow, C-W Chen, S Corrochano, A Acevedo-Arozena, DE Gordon, A A Peden, M Lichtenberg, FM Menzies, B Ravikumar, S Imarisio, S Brown, CJ O’Kane, and DC Rubinsztein Alpha-synuclein impairs macroautophagy: implications for Parkinson’s disease. J. Cell Biol. 190, 1023-1037 (2010).

TJ van Ham, M Holmberg, A van der Goot, E Teuling, M Garcia-Arencibia, H Kim, D Du, KL Thijssen, M Wiersma, R Burggraaff, P van Bergeijk, J van Rheenen, G Jerre van Veluw, RMW Hofstra, DC Rubinsztein and EAA Nollen. Identification of MOAG-4/SERF as a  regulator of age-related proteotoxicity. Cell 142, 601-612 (2010).