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  • Human Pluripotent Stem Cells: Tools for Cardiovascular Medicine
    • - Timothy J. Kamp, MD, PhD (2011/09/14)
    • - Category : Stem Cell
    Human embryonic stem cells (ESCs) and human induce pluripotent stem cells (iPSCs) can provide theoretically unlimited supplies of human cardiac myocytes(CMs) for research and potentially clinical applications. Furthermore, generation of iPSCs from genetically diverse samples will enable creation of libraries of iPSCs that will better reflect the genetic diversity of the population as well as generate disease-specific models.

    However, the promise of these unique cells is only starting to be realized as technical roadblocks are overcome and proof-of-principle studies are undertaken. For example, the differentiation of human pluripotent stem cells to cardiomyocytes has been highly inefficient, but here we will described a novel approach using extracellular matrix in combination with growth factors to produce in high yield and purity CMs.

    The presentation will also describe the use of human iPSCs to model Pompe Disease and Long QT syndrome. The final section will describe a unique cardiac progenitor cell population that we have isolated using the SRF-cardiac specific enhancer which may prove useful in cardiac repair.

    Human Pluripotent Stem Cells: Tools for Cardiovascular Medicine

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  • (1) The Role of BRCA1 and BRCA2 in Caucasian and African-American Women in a Population-Based Study (2) Hemolysis and Personalized Medicine in Sickle Cell Disease: A Global Perspective
    • - (1) Elaine Ostrander, PhD, Senior Investigator and Chief, Cancer Genetics Branch, NHGRI (2) James G. Taylor, MD, Assistant Clinical Investigator, Cardiovascular and Pulmonary Branch, NHLBI (2011/09/14)
    • - Category : Clinical Center Grand Rounds
    CC Grand Rounds

    For more information, visit: http://www.cc.nih.gov/about/news/grcurrent.html

    (1) The Role of BRCA1 and BRCA2 in Caucasian and African-American Women in a Population-Based Study (2) Hemolysis and Personalized Medicine in Sickle Cell Disease: A Global Perspective

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  • Lessons from the MMR scare
    • - Fiona Godlee, Editor in Chief, British Medical Journal (2011/09/13)
    • - Category : Special
    Please join BMJ Editor Fiona Godlee for a discussion of the stunning investigation she published earlier this year that revealed the MMR scare was based not on bad science but on deliberate fraud. The three-part series was produced by journalist Brian Deer, who spent seven years investigating Andrew Wakefield？？？s infamous study linking the MMR vaccine with autism, discovering Wakefield had been paid by a lawyer to influence his results and had blatantly manipulated the study data.

    In an editorial accompanying Deer？？？s report, Godlee and colleagues noted, ？？？Science is based on trust. Without trust, research cannot function and evidence based medicine becomes a folly. Journal editors, peer reviewers, readers, and critics have all based their responses to Wakefield？？？s small case series on the assumption that the facts had at least been honestly documented. Such a breach of trust is deeply shocking. And even though almost certainly rare on this scale, it raises important questions about how this could happen, what could have been done to uncover it earlier, what further inquiry is now needed, and what can be done to prevent something like this happening again.？？？

    For more information, visit
    http://www.fic.nih.gov/News/Events/Pages/fiona-godlee-mrr.aspx

    Lessons from the MMR scare

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  • The Skin You？？？re In: Making Progress in Eliminating Health Inequalities
    • - Thomas A. LaVeist Ph.D. (2011/09/13)
    • - Category : Special
    Medicine: Mind the Gap, An NIH Seminar Series

    For more information, visit: http://consensus.nih.gov/mindthegap/default.htm

    The Skin You？？？re In: Making Progress in Eliminating Health Inequalities

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  • Overweight and Obesity - Public and Scientific Challenges and Perspectives
    • - Expert Panel Featuring Dr. Van S. Hubbard, Ms. Janet de Jesus, Dr. Amber Courville, and Ms. Karen Miller-Kovachs (2011/09/13)
    • - Category : Focus on You Wellness
    Kickoff event for the second annual NIH Health and WEllness Expo

    For more information, visit: http://dats.ors.od.nih.gov/wellness/expo2011.html

    Overweight and Obesity - Public and Scientific Challenges and Perspectives

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  • Suicide in the U.S.: Finding Pathways to Prevention
    • - National Institute of Mental Health (2011/09/13)
    • - Category : Special
    September is World Suicide Awareness Month. The National Institute of Mental Health is sponsoring a discussion panel of suicide prevention experts and researchers.

    For more information, visit: http://www.nimh.nih.gov/health/topics/suicide-prevention/index.shtml

    Suicide in the U.S.: Finding Pathways to Prevention

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  • First Annual NIH Safety Day 2011
    • - ORS Division of Occupational Health and Safety (2011/09/10)
    • - Category : Occupational Health & Safety Lectures (NIH Only)
    ？？？FIRST ANNUAL NIH SAFETY DAY 2011？？？

    Opening Ceremony with NIH Leadership

    Presented by the Office of Research Services, Office of Research Facilities and the National Institutes of Health Occupational Safety & Health Committee

    First Annual NIH Safety Day 2011

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  • Grabbing the Cat by the Tail: Discrete Steps by a DNA Packaging Motor and their Inter-Subunit Coordination in a Ring-ATPase
    • - Dr. Carlos J. Bustamante (2011/09/09)
    • - Category : Wednesday Afternoon Lectures
    As part of their infection cycle, many viruses must package their newly replicated genomes inside a protein capsid to insure its proper transport and delivery to other host cells. Bacteriophage phi29 packages its 6.6 mm long double-stranded DNA into a 42 nm dia. x 54 nm high capsid using a multimeric ring motor that belongs to the ASCE (Additional Strand, Conserved E) superfamily of ATPases.

    A number of fundamental questions remain as to the coordination of the various subunits in these multimeric rings. The portal motor in phi29 is ideal to investigate these questions. Using optical tweezers, we find that this motor can work against loads of up to ~57 picoNewtons on average, making it one of the strongest molecular motors ever reported. Interestingly, the packaging rate decreases as the prohead is filled, indicating that an internal pressure builds up due to DNA compression. The capsid pressure at the end of the packaging is ~6 MegaPascals, corresponding to an internal force of ~52 pN acting on the motor.

    We have identified where in the mechanochemical cycle the chemical energy of ATP is converted into mechanical work. Using ultra-high resolution optical tweezers, we have performed the first direct measurement of the step size of a translocating ring ATPase. What emerges is a surprising mechanism that involves a step size with a non-integer number of base pairs and that reveals an unexpected degree of coordination among the individual subunits that has not been proposed previously for a ring ATPase.

    For more information, visit:
    The NIH Directors Wednesday Afternoon Lecture Series

    Grabbing the Cat by the Tail: Discrete Steps by a DNA Packaging Motor and their Inter-Subunit Coordination in a Ring-ATPase

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  • First Annual NIH Safety Day 2011
    • - ORS Division of Occupational Health and Safety (2011/09/08)
    • - Category : Focus on You Wellness
    ？？？FIRST ANNUAL NIH SAFETY DAY 2011？？？

    Opening Ceremony with NIH Leadership

    Presented by the Office of Research Services, Office of Research Facilities and the National Institutes of Health Occupational Safety & Health Committee

    First Annual NIH Safety Day 2011

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  • The Therapeutic Misconception and Informed Consent
    • - Franklin G. Miller, PhD, Senior Staff Bioethicist, Department of Bioethics, Clinical Center, NIH (2011/09/08)
    • - Category : Clinical Center Grand Rounds
    Grand Rounds for Clinical Fellows

    For more information, visit: http://www.cc.nih.gov/about/news/grcurrent.html

    The Therapeutic Misconception and Informed Consent

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  • Medicine Dish: Working Together: Outreach and Enrollment of Children and Families in Medicaid and CHIP - Part 1
    • - Presenters: San Felipe - Phyllis Aguilar, Jan Aguilar, Norman Cooeyate, Myrna Dingman, Gary Odasso, Kim-Cuc Dang; IHCRC - Carmelita Skeeter, Jenifer Hamma, Jennifer Welsh, Phyllis Pratt; CMS - Cathy Cope, Kitty Marx (2011/09/08)
    • - Category : CMS - Centers for Medicare & Medicaid Services
    CHIPRA grantees from the Pueblo of San Felipe in NM and Indian Health Care Resource Center in Tulsa, OK will share:
    • Outreach and enrollment activities
    • Challenges encountered and actions taken to overcome them
    • Effective partnerships
    • Advice to others interested in outreach and enrollment of AI/AN children in the Medicaid and CHIP programs
    Next months show will feature CHIPRA grantees at the Indian Health Board of Billings, Blackfeet Tribe Po Ka System of Care and Lake County Tribal Health Consortium.

    Medicine Dish: Working Together: Outreach and Enrollment of Children and Families in Medicaid and CHIP - Part 1

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  • A Long and Winding Road: National Health Reform and the Future of American Health Care
    • - Sara Rosenbaum, JD, Harold & Jane Hirsh Professor, Dept of Health Policy, School of Public Health and Health Services, The George Washington University Medical Center (2011/09/03)
    • - Category : Clinical Center Grand Rounds
    Grand Rounds for Clinical Fellows

    For more information, visit: http://www.cc.nih.gov/about/news/grcurrent.html

    A Long and Winding Road: National Health Reform and the Future of American Health Care

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  • FAITAS DEMO
    • - John Varghese (2011/09/03)
    • - Category : Special
    Demonstration of new FAITAS System to include Q&A session.

    For more information, visit: http://www.fai.gov

    FAITAS DEMO

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  • NIH Town Hall Meeting with Senator Cardin - August 2011 (NIH Only)
    • - Francis Collins and Senator Ben Cardin (D-MD) (2011/09/02)
    • - Category : NIH Only
    A town hall for NIH employees at the request of Senator Cardin.

    NIH Town Hall Meeting with Senator Cardin - August 2011 (NIH Only)

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  • National Childrens Study Research Day
    • - National Childrens Study (2011/08/31)
    • - Category : Conferences
    Learn about current National Childrens Study research and the potential for scientific collaboration and innovation as the Study grows. This is a day dedicated to engaging the scientific community through presentation of the National Childrens Study preliminary data, infrastructure, and development of a plan for new collaborations as the Study evolves.

    For more information, visit: http://www.cvent.com/d/ncqnxf

    National Childrens Study Research Day

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  • NIMH DIRP Update
    • - Dr. Thomas Insel (2011/08/27)
    • - Category : NIH Only
    Update of the NIMH DIRP.

    NIMH DIRP Update

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  • ORS "Brown Bag" Lunch Series - August 2011 (NIH Only)
    • - Dr. Alfred C. Johnson/ Collen Broder (2011/08/25)
    • - Category : NIH Only
    ORS Brown Bag Lunch series is designed to bring together ORS FTE employees in an informal setting to receive the latest information, ask questions, provide feedback and generally discuss and interact on topics of the day.

    For more information, visit: http://www.ors.od.nih.gov

    ORS "Brown Bag" Lunch Series - August 2011 (NIH Only)

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  • Safeguarding Sound Science: Avoiding the Common Pitfalls of Clinical Research Misconduct
    • - Kristen Grace, MD, PhD, Division of Investigative Oversight, Dept of Health and Human Services (2011/08/25)
    • - Category : Clinical Center Grand Rounds
    Grand Rounds for Clinical Fellows

    For more information, visit: http://www.cc.nih.gov/about/news/grcurrent.html

    Safeguarding Sound Science: Avoiding the Common Pitfalls of Clinical Research Misconduct

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  • mHealth Evidence Workshop
    • - Robert Wood Johnson Foundation, McKesson Foundation, National Science Foundation and the NIH (2011/08/19)
    • - Category : Conferences
    Mobile health (mHealth) has the potential to simultaneously reduce the cost of health care and improve our health by encouraging healthy behaviors, providing continuous monitoring to prevent or reduce health problems, reducing acute health care visits, and providing personalized, real-time intervention in the mobile environment. However, traditional methods of evaluation needed to address efficacy and safety in mHealth are not well aligned to the pace of technological development. The mHealth Evidence Meeting will bring together individuals with diverse expertise in data analysis and experimental design to identify innovative methods that can accelerate the evaluation of the efficacy and safety of mHealth technologies. Results from the workshop will be used to define the research agenda for evaluation of mobile health technology.

    mHealth Evidence Workshop

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  • Collaborative/Team Science: Impact and Implementation
    • - Ann Bonham, PhD, Chief Scientific Officer, American Association of Medical Colleges (2011/08/13)
    • - Category : Clinical Center Grand Rounds
    Grand Rounds for Clinical Fellows

    For more information, visit: http://www.cc.nih.gov/about/news/grcurrent.html

    Collaborative/Team Science: Impact and Implementation

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