전체 8345
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- Memory CD8 T Cells
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- - Dr. Steve Jameson, University of Minnesota (2011/11/15)
- - Category : Immunology
- Immunology Interest Group Seminar
Memory CD8 T Cells
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- Clinical Trials and Translational Research Advisory Committee (CTAC) - November 2011
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- - National Cancer Institute (NCI) Coordinating Center for Clinical Trials (CCCT) (2011/11/12)
- - Category : Clinical Trials and Translational Research Advisory Committee
- The Committee makes recommendations on the NCI-supported national clinical trials enterprise to build a strong scientific infrastructure by bringing together a broadly developed and engaged coalition of stakeholders involved in the clinical trials process. Additionally, the Committee makes recommendations regarding the effectiveness of NCI's translational research management and administration program, including the needs and opportunities across disease sites, patient populations, translational developmental pathways, and the range of molecular mechanisms responsible for cancer development.
For more information, visit: http://deainfo.nci.nih.gov/advisory/ctac/ctacmeetings.htm
Clinical Trials and Translational Research Advisory Committee (CTAC) - November 2011
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- SEER-Medicare Data Training Workshop (Day 1)
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- - NCI, NIH (2011/11/11)
- - Category : Conferences
- The purpose of the training is to assist investigators who are new to the SEER-Medicare data in the understanding some of the methodological issues associated with using these data fro epidemiologic and health services research
For more information, visit: http://conference.novaresearch.com/SEER
SEER-Medicare Data Training Workshop (Day 1)
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- Lipid-based Nanoparticles and Triggered Chemotherapy (NIH Only)
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- - Robert Blumenthal, PhD, NCI, NIH (2011/11/11)
- - Category : NIH Only
- Nanomedicine-Nanotech Interest Group
The structural basis of the cell membrane is a lipid bilayer of about 4 nm thick, made up of two monolayers of lipids. According to the classical model membrane-embedded proteins perform their functions while floating unencumbered in a sea of lipids. In this context the lipids play a passive role as a solvent for membrane proteins and no special consideration is given to the particular environment in which membrane proteins function. However, it has been recognized that many membrane functions (e.g. fusion, signaling, and permeability) are strictly dependent on the particular nano-environment in which these processes take place. Development of emerging techniques to study membrane phenomena at the nanoscale has been very instrumental in furthering our understanding of these membrane functions. The current view is that membranes are patchy with nanoscale segregated regions of structure and function (nanodomains) and that lipid regions vary in thickness and composition. Monolayers, multilayers and liposomes have frequently been used as simple model membranes in attempts to gain insight into more complex natural structures and nano-domain formation. In order to probe the domain structure and motional dynamics of biological membranes and their models, we have incorporated photosensitive moieties into lipid structures. I will present our basic research on understanding nanoscale membrane properties that affect membrane signaling, fusion and permeability. I will then show how we have applied these insights to construct theranostic lipid-based nanoparticles that upon triggering by heat or light are able to release their chemotherapeutic contents into a localized diseased area of the body.
Lipid-based Nanoparticles and Triggered Chemotherapy (NIH Only)
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- International Research; Exploitation;Case Discussion (Course 7)
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- - Alan Wertheimer, PhD; Seema Shah, JD; Joe Millum, PhD (2011/11/11)
- - Category : Bioethics
- Ethical and Regulatory Aspects of Clinical Research
International Research; Exploitation;Case Discussion (Course 7)
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- NCI Board of Scientific Advisors - November 2011
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- - NCI, Division of Extramural Activities (2011/11/10)
- - Category : NCI Board of Scientific Advisors
- NCI, Board of Scientific Advisors Meeting
For more information, visit:
http://deainfo.nci.nih.gov/advisory/bsa/bsa.htm
NCI Board of Scientific Advisors - November 2011
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- Managing Conflicts of Interest in Initial Peer Review (HHS Only)
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- - Sally Amero, OER, Richard Panniers CSR, Lynn Rust, NIAID and Rudy Pozzatti, NHGRI (2011/11/10)
- - Category : ESA (HHS Only)
- Is it getting harder to put together a review panel because of all the conflicts? The Office of Extramural Research has responded to your pleas for help by revising policy (NOT-OD-11-120) to help you manage conflicts of interest in NIH initial peer review. The revised policy is intended to facilitate reviews that involve multi-site or multi-component projects, consortia, networks, aggregate datasets, and/or multi-authored publications, but includes numerous changes that apply to single-project or single-site applications as well. This training event will outline the major policy changes; discuss case studies; and answer questions from the audience
For more information, visit
http://odoerdb2.od.nih.gov/oer/training/esa/esa_training_20111107.htm
Managing Conflicts of Interest in Initial Peer Review (HHS Only)
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- G Protein Signaling to Neuronal Calcium Channels Directed by Cell-Specific Alternative Splicing
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- - Diane Lipscombe, PhD, Brown University (2011/11/10)
- - Category : Neuroscience
- Neuroscience Seminar Series
Dr. Lipscombes lab is interested in the cellular mechanisms used to optimize calcium ion channel function. Calcium ion channels regulate many critical neuronal functions including transmitter release, nerve growth, and synaptic plasticity. Their current research focus is on cell-specific alternative splicing in the mammalian nervous system. They study cellular mechanisms that control calcium channel function in normal as well as in disease states, including chronic pain and mental illness.
Voltage-gated calcium channels, the gatekeepers of excitation-driven calcium entry in all excitable cells, control a diverse array of functions. Alternative splicing expands functional capabilities and contributes greatly to the expansion of the proteome required to support complex brain functions. They study alternative splicing of voltage-gated calcium channels. Their work is relevant to basic mechanisms that control channel function in normal and in disease states, including chronic pain.
For more information, visit: http://neuroseries.info.nih.gov
G Protein Signaling to Neuronal Calcium Channels Directed by Cell-Specific Alternative Splicing
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- TRACO: RNAi: Cervical cancer
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- - Natasha Caplen: John Schiller (2011/11/10)
- - Category : TRACO
- The Translational Research in Clinical Oncology (TRACO) course will be held on Monday afternoons from September to December at the Bethesda campus, Bldg. 50 ground floor auditorium. TRACO is designed to provide an overview of general principles of cancer biology and treatment, epidemiology, mechanisms of resistance, metastasis, use of preclinical models, and identification of novel molecular targets. Participants will have an unprecedented opportunity to learn new information, glimpse into future developments of translational research in clinical oncology, meet leaders in cancer research, and interview cancer survivors. These courses are part of a curriculum for training NCI clinical and postdoctoral fellows.
For more information, visit: http://ccr.cancer.gov/careers/courses/traco
TRACO: RNAi: Cervical cancer
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- U.S. Secretary of State Hillary Rodham Clinton to Speak on Global HIV/AIDS
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- - U.S. Secretary of State Hillary Rodham Clinton and NIH Office of the Director (2011/11/10)
- - Category : Special
- On November 8, 2011, Secretary of State Hillary Rodham Clinton will deliver remarks on the future of the global HIV/AIDS epidemic at approximately 11:00 a.m. at the National Institutes of Health. The Secretary will outline a vision for turning the tide on HIV/AIDS, drawing on the 30 years of U.S. leadership in the fight against HIV/AIDS and recent scientific advances.
U.S. Secretary of State Hillary Rodham Clinton to Speak on Global HIV/AIDS
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- "Show off Your Apps: Innovative Uses of NLM Information" Awards Ceremony
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- - US Chief Technology Officer Aneesh Chopra, HHS Chief Technology Officer Todd Park (2011/11/09)
- - Category : Special
- The winners of the National Library of Medicine software development challenge will be recognized and will demonstrate their winning applications.
"Show off Your Apps: Innovative Uses of NLM Information" Awards Ceremony
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- NCI Directors Awards 2011
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- - Dr. Harold Varmus (2011/11/09)
- - Category : Special
- Each year at the NCI Director's Award ceremony, we recognize the outstanding contributions of our colleagues that aid in the continued advancement of progress at the institute.
NCI Directors Awards 2011
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- Council of Public Representatives Meeting - November 2011
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- - NIH Office of the Director (2011/11/09)
- - Category : Directors Council of Public Representatives
- Council of Public Representatives Advisory Board Meeting
For more information, visit: http://copr.nih.gov
Council of Public Representatives Meeting - November 2011
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- Opening Windows to the Brain: Lessons Learned from the Neuroimaging of Pain
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- - Sean Mackey, M.D., Ph.D., Stanford University School of Medicine (2011/11/09)
- - Category : NCCAM Lectures
- The Stephen E. Straus Distinguished Lecture in the Science of Complementary and
Alternative Medicine series was established to honor Dr. Straus, the founding director
of the National Center for Complementary and Alternative Medicine. This series brings
leading figures in science and medicine to the National Institutes of Health (NIH) to
speak about their perspective on the field of complementary and alternative medicine
(CAM). The lectures shed light on the evolution of CAM practice and research, and the
current use of CAM by the public.
Sean Mackey, M.D., Ph.D. is chief of the Division of Pain Management and associate professor in the Department of Anesthesia and Pain Management at the Stanford University School of Medicine. Dr. Mackey also serves as director of the Stanford Systems Neuroscience and Pain Lab. Dr. Mackey received his undergraduate and masters degrees in engineering from the University of Pennsylvania School of Engineering and Computer Science in Philadelphia. He received his Ph.D. in electrical and computer engineering from the University of Arizona School of Electrical and Computer Engineering, and his medical degree from the University of Arizona College of Medicine, both in Tucson.
Dr. Mackey？？？s postdoctoral training includes an internship at the Tucson Hospitals Medical Education Program, and residency and a pain management fellowship in the Department of Anesthesiology at the Stanford University Medical Center. Dr. Mackey？？？s current research focus includes virtual reality and real-time fMRI, cortical restructuring in patients with chronic pain, cognitive load and perceived pain intensity, and fMRI of the human cervical spine.
Dr. Mackey is a member of the American Society of Anesthesiologists, American Pain Society, American Academy of Pain Medicine, and the International Association for the Study of Pain.
For more information, visit: http://nccam.nih.gov/news/events/lectures/
Opening Windows to the Brain: Lessons Learned from the Neuroimaging of Pain
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- Informed Consent; Research with Persons at Risk for Impaired Decision-Making; Ethics of Use of Stored Tissue and Data (Course 6)
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- - Christine Grady RN, PhD; Don Rosenstein, MD; Sara Hull, PhD (2011/11/05)
- - Category : Bioethics
- Ethical and Regulatory Aspects of Clinical Research
Informed Consent; Research with Persons at Risk for Impaired Decision-Making; Ethics of Use of Stored Tissue and Data (Course 6)
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- NLM Extramural Programs Informatics Lecture Series for NLM？？？s 175th Anniversary: ？？？Machine Learning Approaches to the Genetic Analysis of Complex Traits？？？
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- - Jason H. Moore, PhD (2011/11/05)
- - Category : Special
- The sequencing of the human genome has made it possible to identify an informative set of more than one million single nucleotide polymorphisms (SNPs) across the genome that can be used to carry out genome-wide association studies (GWAS). The availability of massive amounts of GWAS data has necessitated the development of new biostatistical methods for quality control, imputation, and analysis issues including multiple testing. This work has been successful and has enabled the discovery of new associations that have been replicated in multiple studies. However, it is now recognized that most SNPs discovered via GWAS have small effects on disease susceptibility and thus may not be suitable for improving healthcare through genetic testing. One likely explanation for the mixed results of GWAS is that the current biostatistical analysis paradigm is by design agnostic or unbiased in that it ignores all prior knowledge about disease pathobiology. Further, the linear modeling framework that is employed in GWAS often considers only one SNP at a time thus ignoring their genomic and environmental context. There is now a shift away from the biostatistical approach toward a more holistic machine learning approach that recognizes the complexity of the genotype-phenotype relationship that is characterized by significant heterogeneity and gene-gene and gene-environment interaction. We argue here that machine learning has an important role to play in addressing the complexity of the underlying genetic basis of common human diseases.
Jason H. Moore received his B.S. in Biological Sciences at Florida State University where he focused on undergraduate research in molecular evolution. He then attended graduate school at the University of Michigan where he completed an M.A. in Applied Statistics and an M.S. and Ph.D. in Human Genetics. After receiving his Ph.D. in 1999, Dr. Moore accepted a tenure-track faculty position in the Center for Human Genetics Research, the Vanderbilt-Ingram Cancer Center, and Department of Molecular Physiology and Biophysics at Vanderbilt University Medical School. Dr. Moore was promoted to Associate Professor with tenure in 2003 and was awarded an endowed Ingram Professorship in Cancer Research. In 2004, Dr. Moore moved to Dartmouth Medical School as the Frank Lane Research Scholar in Computational Genetics, Associate Professor of Genetics and Associate Professor of Community and Family Medicine. In 2008 he was promoted to Professor of Genetics and Community and Family Medicine with tenure. In 2010 he was awarded an endowed Third Century Professorship and appointed founding Director of the Institute for Quantitative Biomedical Sciences. Dr. Moore？？？s NLM-funded research program focuses on the development, evaluation and application of computational methods for identifying and characterizing gene interactions in studies of common human diseases. He currently serves as Editor-in-Chief of the journal BioData Mining and is a member of the NLM Biomedical Library and Informatics Review Committee. This lecture will be available through NIH video cast.
NLM Extramural Programs Informatics Lecture Series for NLM？？？s 175th Anniversary: ？？？Machine Learning Approaches to the Genetic Analysis of Complex Traits？？？
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- Chemoprevention using Natural Dietary Components to Target Cancer Stem Cells
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- - Max S. Wicha, MD, University of Michigan (2011/11/05)
- - Category : Stars in Nutrition
- Stars in Nutrition and Cancer
Max Wicha is the founding Director of the University of Michigan Comprehensive Cancer Center. He also serves as the Distinguished Professor of Oncology, Professor of Internal Medicine and is nationally known for his research in the field of cancer stem cells. His laboratory was part of the team that first identified breast cancer stem cells, the first such cells identified in solid tumors. His laboratory identified a number of stem cell markers and developed in vitro and mouse models to isolate and characterize these cells, models which have been widely utilized in the field.
LECTURE OBJECTIVES: 1) to understand the role of stem cells in breast carcinogenesis; 2) to gain knowledge of the pathways that isolate normal and malignant stem cells; and 3) to understand how these stem cell regulating pathways may be regulated by dietary components, including curcumin and sulforaphane.
For more information, visit: http://prevention.cancer.gov/newsandevents/events/20111102
Chemoprevention using Natural Dietary Components to Target Cancer Stem Cells
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- Progenitor T cells, from In Vitro Generations to In Vivo Function
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- - Dr. Juan Zuniga-Pflucker, University of Toronto (2011/11/05)
- - Category : Immunology
- Immunology Interest Group Seminar
Progenitor T cells, from In Vitro Generations to In Vivo Function
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- Epigenetic plasticity and somatic memory in reprogrammed hematopoietic progenitors
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- - Elias Zambidis, MD/PhD (2011/11/04)
- - Category : Stem Cell
- NIH CRM/SCIG Lecture Series: The Zambidis lab studies the formation of pluripotent stem cells and hematopoietic, endothelial and cardiac differentiation with a focus on the potential therapeutic use of pluripotent stem cell-derived cells. Projects include studying the developmental biology of hematopoiesis as well as improving the differentiation of human embryonic stem cells and human induced pluripotent stem cells to hematopoietic lineages including erythrocytes and lymphocytes; improving the differentiation of human pluripotent stem cells to endothelial cells capable of forming the vasculature system; and improving the differentiation of human embryonic stem cells (hESC) and human induced pluripotent stem cells (hiPSC) to the cardiac lineage.
The research team also studies the developmental biology of gastrulation and cardiogenesis in model organisms and explores potential applications of pluripotent stem cell-derived cardiac in tissue engineering, regenerative medicine, cardiotoxicity screening and novel drug discovery.
Epigenetic plasticity and somatic memory in reprogrammed hematopoietic progenitors
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- NIH Blue Ribbon Panel on NIEDL in Boston Meeting - November 2011
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- - NIH Office of the Director (2011/11/04)
- - Category : NIH Blue Ribbon Panel
- Advisory committee meeting
For more information, visit
http://nihblueribbonpanel-bumc-neidl.od.nih.gov
NIH Blue Ribbon Panel on NIEDL in Boston Meeting - November 2011