전체 8345
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- National Cancer Advisory Board Meeting - June 2011
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- - NCI (2011/07/09)
- - Category : National Cancer Advisory Board
- The 158th meeting of the National Cancer Advisory Board
National Cancer Advisory Board Meeting - June 2011
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- OppNet Forum: Survey Biology
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- - Drs. Carol Ryff and David Weir (2011/07/09)
- - Category : Oppnet
- Survey Biology: Using biopsychosocial surveys to study how social, economic, behavioral, and biological factors impact life course trajectories of health, productivity, disability, and subjective and economic well-being.
OppNet Forum: Survey Biology
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- Council of Councils Meeting (NIH Only)
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- - James Anderson (2011/07/09)
- - Category : NIH Only
- The NIH Council of Councils will meet to carry out concept clearance of proposals for potential Common Fund support and consider potential changes to the Transformative R01 program. Updates about NIH and DPCPSI activities will be presented by Dr. Francis Collins and Dr. James Anderson.
For more information, visit: http://dpcpsi.nih.gov/council/index.aspx
Council of Councils Meeting (NIH Only)
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- Bisphosphonates: Pros and Cons in Bone Health
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- - (1) Michael T. Colins, MD, Chief, Skeletal Clinical Studies Unit, Craniofacial and Skeletal Diseases Branch, NIDCR (2) Deborah E. Sellmeyer, MD, Associate Professor of Medicine, Johns Hopkins University School of Medicine (2011/07/09)
- - Category : Clinical Center Grand Rounds
- CC Grand Rounds
For more information, visit: http://www.cc.nih.gov/about/news/grcurrent.html
Bisphosphonates: Pros and Cons in Bone Health
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- Regulation of limb development:linking early patterning, growth and morphogenesis
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- - Susan Mackem, M.D., Ph.D., National Cancer Institute, NIH (2011/07/08)
- - Category : NIH Directors Seminars
- Directors Seminar Series
Susan Mackem received her PhD from the University of Chicago as an MSTP trainee and completed her MD at The Johns Hopkins University School of Medicine in 1984. After residency training in Pathologic Anatomy, she continued her training as a cancer expert in the Laboratory of Pathology, NCI. In 1995 she became a tenure track investigator and in 2008, she joined the Cancer and Developmental Biology Laboratory, NCI, where she is currently a senior investigator.
Dr. Mackems lab studies limb development as a paradigm to understand how signaling networks orchestrate the formation of a complex tissue. The lab uses combined genetic, genomic, and biochemical approaches to study transcription factors and signaling cascades that regulate the formation and correct pattern of the different digit types (from thumb to pinky) and unravel the regulatory hierarchy between early patterning and digit morphogenesis. A major focus has been the role of Sonic Hedgehog and its signaling targets. Recently, Dr. Mackems group showed that Sonic hedgehog is required only very transiently to specify digit pattern but for an extended period to promote growth and determine digit numbers. Their results challenge current paradigms on Shh function as a temporally integrated morphogen. The roles of the Gli3 hedgehog-effector and 5HoxD homeobox gene targets extend from early to late stages of limb development, and the lab has found that they cooperate in the late morphogenetic realization of patterning cues by regulating the segmentation of digits during joint formation.
Regulation of limb development:linking early patterning, growth and morphogenesis
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- Immune Adaptations to the Intestinal Microbiota
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- - Lara Hooper, UT Southwestern Medical Center (2011/07/08)
- - Category : Immunology
Immune Adaptations to the Intestinal Microbiota
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- Basic Science and Clinical Application of Vascular Endothelial Growth Factor
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- - Napoleone Ferrara, M.D., Ph.D., Genentech, 2010 Lasker Award (2011/07/08)
- - Category : Special
- Fifth Sayer Vision Research Lecture
Dr. Napoleone Ferrara, winner of a 2010 Lasker Award, will deliver the fifth Sayer Vision Research Lecture.
Ferrara, a Fellow at Genentech, Inc., has spent nearly 30 years working to understand the mechanisms of angiogenesis (formation of new blood vessels). He is credited with isolating and cloning vascular endothelial growth factor (VEGF), a protein that plays a key role in angiogenesis. Ferrara and colleagues showed that cancerous tumors are able to grow and spread by attracting new blood vessels to the tumor site and that VEGF inhibition suppresses the growth of tumors by depriving blood supply. Dr. Ferrara went on to develop a VEGF antibody, called Avastin, to treat cancer. This novel agent was approved by the FDA in 2004 for the treatment of metastatic colon cancer.
Ferrara？？？s laboratory next developed another VEGF antibody called Lucentis for the treatment of wet age-related macular degeneration (AMD), a leading cause of vision loss in older Americans. Clinical trials established Lucentis as the first treatment for wet AMD to offer significant visual improvement. Lucentis was approved by the FDA in 2006.
In 2010, Dr. Ferrara was honored with the prestigious Lasker-DeBakey Clinical Medical Research Award for the discovery of VEGF and the development of Lucentis. His laboratory is currently expanding its scope to investigate other tumor growth factors, in particular those produced by myeloid cells and fibroblasts.
In 2006, Dr. Jane Sayer, an NIH research scientist in NIDDK, established the Sayer Vision Research Lecture and Award at the Foundation for the National Institutes of Health (FNIH), in partnership with the National Eye Institute (NEI) at NIH, to honor her family and the memory of her parents, Winthrop and Laura Sayer.
The lecture and award series provides an opportunity for honorees to explore areas of interdisciplinary collaboration, such as angiogenesis, that may lead to advances in diverse medical specialties with relevance to vision research. A number of factors place vision science in a position for major advances in the near future-including the large number of identified genes relevant to eye disease and the relative ease with which pathology can be visualized and documented in the eye.
For more information, visit
http://www.nei.nih.gov/news/special/sayer.asp
Basic Science and Clinical Application of Vascular Endothelial Growth Factor
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- Regional Specifications of Adult Neural Stem Cells
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- - Arturo Alvarez-Buylla, Ph.D., University of California, San Francisco (2011/07/01)
- - Category : Neuroscience
- Neuroscience Seminar Series
The Alvarez-Buylla Lab is interested in the function and regulation of neural stem cells in the adult mammalian brain. They address questions about the mechanisms of neuronal birth, migration, and differentiation, and how neural stem cells or their immediate progeny may be related to brain tumor initiation. The subventricular zone (SVZ), the most extensive germinal niche in the adult mammalian brain, contains large numbers of neural stem cells that can generate new neurons and glial cells throughout life. By means of chain migration, young neurons born in the SVZ reach the olfactory bulb in the mouse brain, where they become fully integrated into functional circuits. The Alvarez-Buylla Lab has identified that the neural stem cells in the SVZ are a subpopulation of astrocytes and that adult neural stem cells are heterogeneous with particular types of neurons derived from progenitors from specific locations of the mouse SVZ.
Recently, Dr. Alvarez-Buylla been investigating the properties and ontogeny of astrocytes that function as stem cells in the rodent and human brain, as well as the regulation of their proliferation and the mechanisms that control their migration in the adult brain. How do cells migrate and orient during journeys through the very complex terrain of the adult brain? Once young neurons reach their destination, they need to integrate into neural circuits that are already functional. How is this accomplished? How do these new neurons contribute to plasticity without disturbing circuits that are already active? These are just some of the questions that drive the research in the Alvarez-Buylla lab.
For more information, visit: http://neuroseries.info.nih.gov
Regional Specifications of Adult Neural Stem Cells
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- National Science Advisory Board for Biosecurity (NSABB)
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- - NIH Office of Biotechnology Activities (2011/06/30)
- - Category : National Science Advisory Board for Biosecurity
- The NSABB was established to advise on oversight of dual use life sciences research, defined as biological research that generates information and technologies that could be misused to pose a biological threat to public health and other aspects of national security.
The June 23 meeting will focus on:- an update of Federal activities relevant to the mission of the NSABB
- review of proposed NSABB Culture of Responsibility Working Group Draft Report: "Guidance for Enhancing Personnel Reliability and Strengthening the Culture of Responsibility at the Local Level"
- NSABB Outreach and Education Working Group Draft Report: "Strategies to Educate Non-Traditional Audiences about Dual Use Research in the Life Sciences: Amateur Biologists and Scientists in Non-Life Science Disciplines;"
- update on activities of NSABB Working Groups on Codes of Conduct
- International Engagements
- Journal Review Policies
- Planning for future NSABB Meetings and Activities
National Science Advisory Board for Biosecurity (NSABB)
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- The Health Data Initiative Forum 2011 - Apps Demonstration Session C
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- - U.S. Department of Health and Human Services and the Institute of Medicine (2011/06/29)
- - Category : Conferences
- The apps demonstration sessions will present a range of innovative tools and apps developed using health data that focus on consumers, care, and communities.
For more information, visit: http://www.iom.edu/healthdataforum
The Health Data Initiative Forum 2011 - Apps Demonstration Session C
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- Steroids in Sepsis - Review of Clinical Trials and Preclinical Studies in a Canine Model
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- - (1) Charles Natanson, MD, Senior Investigator and Chief, Anesthesia Section, Critical Care Medicine Department, CC (2) Peter Minneci, MD, Instructor in Surgery, Chief Surgical Resident, The Childrens Hospital of Philadelphia, University of Pennsylvania School of Medicine (2011/06/28)
- - Category : Clinical Center Grand Rounds
- CC Grand Rounds
For more information, visit: http://www.cc.nih.gov/about/news/grcurrent.html
Steroids in Sepsis - Review of Clinical Trials and Preclinical Studies in a Canine Model
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- Resources for Children and Adults with Long-Term Needs
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- - Haydee M. M. DePaul, Ph.D., LifeWork Strategies (2011/06/28)
- - Category : Parenting
- LUNCH AND LEARN DEPENDENT CARE SEMINAR
This seminar will focus on ？？？what comes next？？？ for parents and caregivers of dependents with long-term needs. Topics will include caregiving and schooling alternatives, job preparation programs, adult care services, legal and financial considerations, as well as how to be an advocate for those with long-term needs.
Handout Slides
For more information, visit
http://does.ors.od.nih.gov/childcare
Resources for Children and Adults with Long-Term Needs
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- The Health Data Initiative Forum 2011 - Apps Demonstration Session B
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- - U.S. Department of Health and Human Services and the Institute of Medicine (2011/06/26)
- - Category : Conferences
- The apps demonstration sessions will present a range of innovative tools and apps developed using health data that focus on consumers, care, and communities.
For more information, visit: http://www.iom.edu/healthdataforum
The Health Data Initiative Forum 2011 - Apps Demonstration Session B
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- Curing Diabetes One Fish at a Time: The Long Road of Translational Research
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- - Dr. Didier Stainier, University of California in San Francisco (2011/06/26)
- - Category : Wednesday Afternoon Lectures
- Our work is concerned with the formation, function and homeostasis of organs during vertebrate development. We are interested in understanding the cellular and molecular events that underlie cellular differentiation, tissue morphogenesis and organ function during the formation of the cardiovascular system (the heart and the blood vessels) as well as the liver and pancreas. One approach consists of screening for mutations that affect these processes in zebrafish, a vertebrate model system that allows forward genetics as well as embryological studies. We also utilize the tools of chemical genetics to identify pathways that regulate these processes, taking advantage of the high-throughput methods available in zebrafish.
This talk will focus on pancreas development and glucose homeostasis. Specifically, it will address our attempts to increase beta-cell mass via mobilization of stem cells and cell reprogramming. It will also cover the results of our ongoing screens for small molecules designed to 1) enhance beta-cell regeneration, 2) lower gluconeogenesis and 3) enhance beta-cell proliferation. Altogether, these studies aim to provide new therapeutic avenues to treat diabetes.
The NIH Wednesday Afternoon Lecture Series includes weekly scientific talks by some of the top researchers in the biomedical sciences worldwide.
For more information, visit
The NIH Directors Wednesday Afternoon Lecture Series
Curing Diabetes One Fish at a Time: The Long Road of Translational Research
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- Translating DRiPs: The MHC Class I Pathway to Cell Biology Discoveries
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- - Jonathan Yewdell, MD, PhD, Laboratory of Viral Diseases; NIAID NIH (2011/06/26)
- - Category : Immunology
Translating DRiPs: The MHC Class I Pathway to Cell Biology Discoveries
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- NCI, Board of Scientific Advisors Meeting - June 2011
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- - NCI, Division of Extramural Activities (2011/06/25)
- - Category : NCI Board of Scientific Advisors
- The 49th meeting of the Board of Scientific Advisors
NCI, Board of Scientific Advisors Meeting - June 2011
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- The Perisynaptic Endocannabinoid Signalosome: Mechanisms and Disease
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- - Olivier Manzoni, Ph.D., Institut de Neurobiologie de la Mediterranee, France (2011/06/24)
- - Category : Neuroscience
- Neuroscience Seminar Series
The goal of Dr. Manzoni？？？s lab is to understand the molecular and cellular basis of synaptic plasticity, a fundamental property of neuronal networks. Specifically, his research has investigated the role of the endocannobinoid and opioid system in synaptic plasticity and disease states in the meso-cortical-limbic circuit. Dr. Manzoni is Director of the ？？？Physiology of Synaptic Transmission？？？ team that was first established at University of Bordeaux in 2002 and it has recently moved to INMED, Marseille. In 2010, Dr. Manzoni received a NARSAD Independent Investigator Award.
For more information, visit: http://neuroseries.info.nih.gov
The Perisynaptic Endocannabinoid Signalosome: Mechanisms and Disease
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- Linking the pigmentary response to DNA repair in melanocytes
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- - Dr. John D. Orazio, University of Kentucky (2011/06/23)
- - Category : DNA Repair
- DNA Repair Interest Group
Linking the pigmentary response to DNA repair in melanocytes
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- NIH RECOMBINANT DNA ADVISORY COMMITTEE 125TH MEETING (Day 1)
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- - NIH (2011/06/22)
- - Category : Recombinant DNA Advisory Committee
- NATIONAL INSTITUTES OF HEALTH RECOMBINANT DNA ADVISORY COMMITTEE 125TH MEETING
NIH RECOMBINANT DNA ADVISORY COMMITTEE 125TH MEETING (Day 1)
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- NIH RECOMBINANT DNA ADVISORY COMMITTEE 125TH MEETING (Day 3)
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- - NIH (2011/06/22)
- - Category : Recombinant DNA Advisory Committee
- NIH RAC
NIH RECOMBINANT DNA ADVISORY COMMITTEE 125TH MEETING (Day 3)