전체 8345
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- The Genetics and Neurobiology of Social Behaviors; Understanding How We Mate, Fight, and Parent
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- - Nirao Shah, MD, PhD, University of California, San Francisco (2012/11/07)
- - Category : Neuroscience
- Neuroscience Seminar Series
Dr. Nirao Shah is interested in understanding the molecular and neural control of instinctual social behaviors. Using mice as a model organism, his lab focuses on dissecting the mechanisms that generate sexually dimorphic behaviors such as mating, aggression, and parental care. Gonadal sex hormones are critical for the appropriate display of these sexually dimorphic behaviors in essentially all vertebrates. Recent data from the Shah lab have revealed the molecular mechanisms that underlie this process whereby estrogen, progesterone, and testosterone control male and female repertoires of behavior. Dr. Shah will present a novel genetic strategy developed in his lab that permits the targeted ablation of any desired set of neurons. Using this approach, they have identified a small group of neurons in the brain that control sexual behavior in females. These findings have unique translational implications, which bear on the fact that many common neurological and psychiatric conditions in humans such as autism, drug addiction, and Parkinson？？？s disease are present in sex-skewed ratios.
For more information go to http://neuroseries.info.nih.gov
The Genetics and Neurobiology of Social Behaviors; Understanding How We Mate, Fight, and Parent
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- Mechanisms of Age-Dependent Neurodegeneration in Alzheimer？？？s and Parkinson？？？s Diseases
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- - Dr. Jie Shen, Harvard Medical School (2012/11/04)
- - Category : Gerontology
- The Geroscience Interest Group (GSIG) cordially invites you to the seminar listed above. Dr. Shen is a Professor of Neurology at Harvard Medical School and Brigham and Women？？？s Hospital in Boston, Massachusetts. Her research interests focus on the physiological functions of gene products responsible for familial forms of Alzheimer？？？s disease (AD) and Parkinson？？？s disease (PD) in relevant neural circuits in the adult brain, and how disease-causing mutations in these gene products lead to age-dependent circuit dysfunction and neurodegeneration. Her laboratory has been the first to generate and analyze gene-targeted mice modeling loss of function for many of these familial AD and PD gene products. Through multidisciplinary investigations combining brain circuit-specific knockouts with electrophysiological and behavioral analyses, her group has uncovered essential roles for Presenilins in neurotransmitter release and neuronal survival in the adult brain. Her proposal that loss of Presenilin function in the adult brain may underlie dementia and neurodegeneration in familial AD, termed the ？？？Presenilin hypothesis？？？, has been particularly influential and has garnered considerable media attention. In addition, her studies of familial PD genes have suggested that impairments in autophagy and mitochondrial function may be mechanistic precursors of dopaminergic neuronal dysfunction and degeneration.
The Geroscience Interest Group (GSIG) is a newly formed trans-NIH group aimed at enhancing opportunities for discussion of the intersection between the biology of aging and the biology of diseases and conditions that are of interest across ICs. It is focused on basic biology, but with a longer view towards translation.
If you are interested in learning more, please visit the GSIG web site:
http://sigs.nih.gov/geroscience/Pages/default.aspx.
Mechanisms of Age-Dependent Neurodegeneration in Alzheimer？？？s and Parkinson？？？s Diseases
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- Clinicopathologic Grand Rounds - Novel, Insidious, Progressive, and Fatal: The Discovery of Aspergillus Tanneri
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- - Steven M. Holland, MD, Chief, Laboratory of Clinical Infectious Diseases and Chief, Immunopathogensis Section, Laboratory of Clinical Infectious Diseases, NIAID (2012/11/03)
- - Category : Clinical Center Grand Rounds
- Clinicopathologic Grand Rounds: Clinical Cases from the NIH Clinical Center
The Clinical Center announces the first Clinicopathologic Grand Rounds, a new quarterly lecture series which will be part of CC Grand Rounds. The Clinicopathologic Grand Rounds will illustrate a complex, challenging clinical case meant to advance medical education and will include discussion of clinical course, relevant laboratory results, radiological, anatomical and histopathologic findings. Dr. Steven M. Holland, Chief, Laboratory of Clinical Infectious Diseases, NIAID will present ？？？Novel, Insidious, Progressive, and Fatal: The Discovery of Aspergillus tanneri.？？？
For more information go to http://www.cc.nih.gov/about/news/grcurrent.html
Clinicopathologic Grand Rounds - Novel, Insidious, Progressive, and Fatal: The Discovery of Aspergillus Tanneri
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- Redox Biology - NADPH Oxidases & Redox Imaging
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- - T. Leto; M. Krishna (2012/11/03)
- - Category : Redox Biology
- The Redox Biology course will be held on Tuesday afternoons (except the
Oct. 4 lectures) from 4:00-6:00 PM starting September 25 through
November 7, 2012 on the Bethesda campus in Bldg. 50, Rooms 1227/1233. In
addition, it will be videocast to the Frederick National Lab at Bldg.
549, Rm. A.
Each lecture will be 50 minutes with ample time for discussion and analysis. A handout for each lecture will be distributed on site.The participation of NIH postdoctoral and clinical fellows interested in redox biology is encouraged.
For more information go to http://ccr.cancer.gov/ca reers/courses/rb
Redox Biology - NADPH Oxidases & Redox Imaging
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- Imaging Tissues by Mass Spectrometry: Molecular Information Beyond the Microscope
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- - Dr. Richard M. Caprioli, Vanderbilt University School of Medicine (2012/11/02)
- - Category : Special
- John Daly Memorial Lecture
Dr. John Daly passed away in 2008 after a very long and successful career with the NIH starting in 1960. This lecture is an annual event to honor his groundbreaking scientific work in organic chemistry and pharmacology.
Dr. Richard M. Caprioli, Stanford Moore Chair in Biochemistry Director, Mass Spec. Research Center, Vanderbilt University School of Medicine
Imaging Tissues by Mass Spectrometry: Molecular Information Beyond the Microscope
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- DCLG Meeting October 2012 (NIH Only)
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- - NCI Office of Advocacy Relations (2012/10/28)
- - Category : NCI Directors Consumer Liaison Group (NIH Only)
- The NCI Directors Consumer Liaison Group (DCLG) is a federal advisory committee comprised of high profile patients, health professionals and career advocates who provide recommendations to the Director of the NCI on behalf of the general public. The DCLG members meet for two days, and consider reports from NCI scientists on the priorities that the Director has asked the members to advise him on. At the conclusion of the meeting, action items are defined, and the DCLG members summarize decisions and action items for the Director. Multiple components of NCIs intramural and extramural programs will be affected by meeting decisions.
DCLG Meeting October 2012 (NIH Only)
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- Basic Cognition for Numbers: Potential Impacts in the Science Classroom
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- - Justin Halberda, Johns Hopkins University (2012/10/28)
- - Category : Science Education
- The Office of Science Education (OSE), ORIP, DPCPSI is hosting a new seminar series for everyone at NIH with an interest in science education, The NIH Science Education Conversations Series. This series will include topics ranging from learning about what the future holds for tomorrows science classroom to how to implement findings from research about the science of education.
Basic Cognition for Numbers: Potential Impacts in the Science Classroom
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- NCI Cohort Consortium Symposium 2012
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- - NCI (2012/10/27)
- - Category : Conferences
- The NCI Cohort Consortium Symposium is jointly sponsored by the Epidemiology and Genomics Research Program (EGRP) of the NCIs Division of Cancer Control and Population Sciences (DCCPS), and the NCIs Division of Cancer Epidemiology and Genetics (DCEG).
The objectives of the Symposium are to:- Identify opportunities and obstacles in combining multiple cross-disciplinary (and cross-institute) cohorts for power
- Describe advantages and constraints of launching new mega cohorts
- Identify issues in building and managing a portfolio of new cohorts across institutes
For more information go to http://epi.grants.cancer.gov/workshops/cohort-symposium/
NCI Cohort Consortium Symposium 2012
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- Redox Biology - Cancer Therapy & Immunology
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- - R. Mitchell; H. Young (2012/10/26)
- - Category : Redox Biology
- The Redox Biology course will be held on Tuesday afternoons (except the
Oct. 4 lectures) from 4:00-6:00 PM starting September 25 through
November 7, 2012 on the Bethesda campus in Bldg. 50, Rooms 1227/1233. In
addition, it will be videocast to the Frederick National Lab at Bldg.
549, Rm. A.
Each lecture will be 50 minutes with ample time for discussion and analysis. A handout for each lecture will be distributed on site.The participation of NIH postdoctoral and clinical fellows interested in redox biology is encouraged.
For more information go to http://ccr.cancer.gov/ca reers/courses/rb
Redox Biology - Cancer Therapy & Immunology
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- Exploitation; Ethical Issues in International Research; Participant Panel/Mock IRB
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- - Alan Wertheimer PhD; Joe Millum PhD; (2012/10/26)
- - Category : Bioethics
- Ethical and Regulatory Aspects of Clinical Research
Exploitation; Ethical Issues in International Research; Participant Panel/Mock IRB
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- (1) The Genetic Basis of Kidney Cancer: A Metabolic Disease (2) From Symptoms to Biomarkers: Modern Myeloma Treatment Strategies
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- - (1) W. Marston Linehan, MD. Chief, Urologic Oncology Branch, Center for Cancer Research, NCI (2) Ola Landgren, MD, PhD, Senior Investigator and Chief, Multiple Myeloma Section, Metabolism Branch, Center for Cancer Research, NCI (2012/10/26)
- - Category : Clinical Center Grand Rounds
- Clinical Center Grand Rounds Lecture Series
(1) The Genetic Basis of Kidney Cancer: A Metabolic Disease (2) From Symptoms to Biomarkers: Modern Myeloma Treatment Strategies
For more information go to http://www.cc.nih.gov/about/news/grcurrent.html
(1) The Genetic Basis of Kidney Cancer: A Metabolic Disease (2) From Symptoms to Biomarkers: Modern Myeloma Treatment Strategies
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- Nuclear damage and miscounted chromosomes: Human T cell leukemia virus transformation of cells
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- - Kuan-Teh Jeang, M.D., Ph.D., National Institute of Allergy and Infectious Diseases (2012/10/26)
- - Category : Wednesday Afternoon Lectures
- Human T-cell Leukemia Virus type 1 (HTLV-1) is a delta-retrovirus that infects approximately 20 million individuals worldwide. HTLV-1 is the etiological agent of adult T-cell leukemia (ATL), a poorly treatable and prevalently fatal disease. The virus encodes a oncoprotein, Tax, which has been shown to transform primary rodent cells. Tax confers immortalization, anchorage-dependent cell growth, and tumorigenicity to rodent cells. Tax can also immortalize human primary T lymphocytes. However, successful transformation of human cells has not been established using Tax. The Tax protein has pleiotropic effects on host-cell gene expression and activates several pathways such as the cyclic AMP responsive binding protein (CREB), the nuclear factor kappa-B (NF-κB), the cyclin-dependant kinases (CDKs), and the Akt pathways. Tax-expressing cells also exhibit nuclear morphological aberrancy, frequent multinucleation, aneuploidy, and loss of function of the tumor suppressor protein p53. Currently, the mechanisms and factors needed for the initiation of ATL by Tax remain incompletely clarified. Dr. Jeang will speak on research insights gained over the past 25 years on how HTLV-1 infection and Tax expression create nuclear damage and aneuploidy in the process of cellular transformation.
The NIH Directors Wednesday Afternoon Lecture Series, colloquially known as WALS, is the highest-profile lecture program at the NIH. Lectures occur on most Wednesdays from September through June from 3:00 to 4:00 p.m. in Masur Auditorium, Building 10 on the NIH Bethesda campus.
Each season includes some of the biggest names in biomedical and behavioral research. The goal of the WALS is to keep NIH researchers abreast of the latest and most important research in the Unites States and beyond. An added treat is the annual J. Edward Rall Cultural Lecture, which features top authors and other cultural icons. All speakers are nominated by the NIH community.
For more information, visit:
The NIH Directors Wednesday Afternoon Lecture Series
Nuclear damage and miscounted chromosomes: Human T cell leukemia virus transformation of cells
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- Interagency Pain Research Coordinating Committee - October 2012
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- - NINDS (2012/10/25)
- - Category : Interagency Pain Research Coordinating Committee
- This is the second meeting of the Interagency Pain Research Coordinating Committee. Discussion items include: an overview of the Federally-funded pain research portfolio, a discussion of top pain research advances over the last 3 years, and an updates on several pain programs at NIH and DOD.
For more information go to http://iprcc.nih.gov/
Interagency Pain Research Coordinating Committee - October 2012
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- Social Connections and Health
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- - Linda J. Waite, PhD, University of Chicago (2012/10/25)
- - Category : BSSR Lecture Series
- NIH BSSR Sixth Matilda White Riley Lecture
Those with more and better higher-quality social connections show better physical and emotional health and better longevity than those who are less well connected. Some have compared the hazards of poor social connections to the hazards of smoking. Perhaps the most important social relationship for adults is marriage, which seems to improve health and lengthen life, unless it is unhappy. But many other social relationships also contribute to health. These include participation in formal organizations such as clubs or religious groups, socializing with friends and family, or membership in a network of others. Recent research has illuminated the pathways through which social connections are linked to health.
This talk begins by discussing the contributions of Matilda White Riley to theories of aging, especially the links between aging and social structures. Riley suggests that people born into different cohorts experience the life course in unique ways because at key developmental stages they pass through different economic, social, sexual, and health contexts. Exposure to marriage has changed over time and over cohorts, as have sexual and marital biographies, in ways affecting health. Social isolation, both as observed and as perceived by the individual, is linked to worse health along a number of dimensions, and characteristics of social networks are linked to health in complex ways. The talk describes the National Social Life, Health and Aging Project, a longitudinal study of the link between social relationships and health at older ages and its contributions to our understanding of this link.
For more information go to http://obssr.od.nih.gov/news_and_events/lectures_and_seminars/matilda_white_riley_annual_lecture/seminars.aspx
Social Connections and Health
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- The Organization and Development of Neurons that Underlie the Sense of Touch
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- - David Ginty, PhD, Johns Hopkins University School of Medicine (2012/10/24)
- - Category : Neuroscience
- Neuroscience Seminar Series
How is our sense of touch transduced peripherally and conveyed centrally? What neurons are involved? How do they perform this function and what kind of specializations do the neurons exhibit? Dr. Ginty？？？s laboratory investigates the function, development, structure and organization of neurons that subserve sensations of touch and pain and their connectivity in the spinal cord. His recent research uses mouse molecular genetic approaches to identify and visualize the axonal projections of physiologically defined classes of low-threshold mechanosensory neurons. Dr. Ginty？？？s research addresses the logic of somatosensory circuit organization as well as mechanisms of touch circuitry assembly during development. Major goals of the laboratory are to define somatosensory circuits of the peripheral nervous system and spinal cord dorsal horn and to determine how these circuits give rise to the perception of touch.
For more information go to http://neuroseries.info.nih.gov
The Organization and Development of Neurons that Underlie the Sense of Touch
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- TRACO: Tumor Imaging & Cancer Disparities
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- - P.Choyke; S. Ambs (2012/10/24)
- - Category : TRACO
- The Translational Research in Clinical Oncology course begins Sept.
10,2012. The course will feature two 1-hour sessions that will usually
occur on Mondays, 4:00 ？？？ 6:00 pm in the Bldg. 50 ground floor auditorium
(Rooms 1227/1233) with videoconferencing to Frederick National Lab(Bldg.
549, Rm. A). In addition, lectures will be archived at
http://videocast.nih.gov.
Each session will have two 50 minutes lectures in basic and clinical sciences with ample time for discussion and analysis. A handout for each lecture will be distributed on site.
For more information go to http://ccr.cancer.gov /careers/courses/traco
TRACO: Tumor Imaging & Cancer Disparities
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- JATS-Con 2012 (Day 2)
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- - NCBI (2012/10/21)
- - Category : Conferences
- JATS-Con is a user group meeting for the NISO Z39.96-2012 Journal Article Tag Suite (formerly the NLM DTDs).
For more information go to http://jats.nlm.nih.gov/jats-con/
JATS-Con 2012 (Day 2)
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- JATS-Con 2012 (Day 1)
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- - NCBI (2012/10/20)
- - Category : Conferences
- JATS-Con is a user group meeting for the NISO Z39.96-2012 Journal Article Tag Suite (formerly the NLM DTDs).
For more information go to http://jats.nlm.nih.gov/jats-con/
JATS-Con 2012 (Day 1)
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- STEP Forum - Change is Inevitable: How to Lead It (HHS Only)
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- - Derrick Tabor (2012/10/20)
- - Category : STEP (HHS Only)
- How do you make a case for change? Change is a process and you can learn how to lead it. What strategies are effective in leading change, minimizing resistance, communicating effectively, building support and motivating others? Come learn the barriers and strategies for overcoming them, navigating around and through them to increase your chance of success in leading change.
For more information go to http://nih-extramural-intranet.od.nih.gov/nih/training/step/step_training_20121018.htm
STEP Forum - Change is Inevitable: How to Lead It (HHS Only)
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- A Strong Workforce is an Inclusive Workforce: What Can YOU Do? (NIH Only)
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- - Kirk M. Bauer, JD, US Army-Retired, Executive Director, Disabled Sports USA (2012/10/20)
- - Category : Disability (NIH Only)
- NIH 2012 Disability Employment Awareness Month Program
The theme for the 2012 Disability Employment Awareness Program is ？？？A Strong Workforce is an Inclusive Workforce: What Can YOU Do?？？？ Mr. Kirk Bauer, J.D., Executive Director, Disabled Sports USA (DSUSA) is joining us as the keynote speaker. As a non-commissioned officer in the U.S. Army, Bauer lost a leg from a hand grenade during an ambush while serving in the Ninth Infantry Division in Vietnam in 1969. As DSUSA？？？s Executive Director, he has taken a small, all volunteer organization, and made it one of the nation？？？s largest sports and recreation organizations for physically disabled individuals, over 100 chapters nationwide, serving more than 60,000 people annually.
Disabled Sports USA is a national nonprofit, 501(c) (3), organization established in 1967 by disabled Vietnam veterans to serve the war injured. DSUSA now offers nationwide sports rehabilitation programs to anyone with a permanent disability. Activities include winter skiing, water sports, summer and winter competitions, fitness and special sports events. Participants include those with visual impairments, amputations, spinal cord injury, dwarfism, multiple sclerosis, head injury, cerebral palsy, and other neuromuscular and orthopedic conditions. Since the war in Iraq was declared, DSUSA has provided free sports rehabilitation instruction in over 20 different sports to the severely wounded service men and women returning from Iraq and Afghanistan with amputations, spinal cord and head injury, as well as blindness.
Other NIH program participants include Lawrence A. Tabak, DDS, Ph.D., Deputy Director, NIH; Debra Chew, J.D., Director, Office of Equal Opportunity and Diversity Management; and Anne E. Sumner, M.D., CEB, Ethnicity & Health Section, NIDDK.
A Strong Workforce is an Inclusive Workforce: What Can YOU Do? (NIH Only)