전체 8345
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- How do you feel? Ion Channels that Sense Temperature and Pressure.
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- - Ardem Patapoutian, PhD, The Scripps Research Institute (2012/03/28)
- - Category : Neuroscience
- Neuroscience Seminar Series
Dr. Patapoutians lab is interested in the molecular description of sensory neuron function. Their research focuses on the somatic sensory neurons that translate thermal, chemical, and mechanical stimuli to impart the characteristics of touch and pain. They have cloned and characterized TRP ion channels involved in detecting temperature and sensory compounds.
They are continuing to identify additional sensory receptors while working towards a more complete understanding of the mechanism of activation of these channels and their in vivo roles in the sense of touch. They are using transgenic and genomic technologies to address these questions. These approaches will yield insights into the basic biology of the peripheral nervous system and may also have an impact on novel treatments for pain.
For more information go to http://neuroseries.info.nih.gov
How do you feel? Ion Channels that Sense Temperature and Pressure.
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- Core Curriculum 4 - Staff Interactions; How The Extramural Team Functions (HHS Only)
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- - Chuck Selden (2012/03/25)
- - Category : Core Curriculum (HHS Only)
- From here on, the structure of the day:
Panel ---> Breakout ---> Panel ---> Breakout ---> Panel ...> Breakout？？？？？？？？？？？？.etc.
The panel discussants will make remarks and describe the helpful staff interactions in which they have participated, spending about 15 minutes per segment, as guided by the ？？？Life Cycle of a Research Concept？？？ timeline based on that provided by Dr. Tingley (NIAID).
Then the Case study breakout groups will discuss cases for 15 to 20 minutes at a time. Especially creative solutions from the breakouts can be shared with the whole class, and the faculty can make brief comments on the different actions or solutions to the cases.
For more information, visit: http://esa.nih.gov/oer/training/esa/esa_cores_2012.htm
Core Curriculum 4 - Staff Interactions; How The Extramural Team Functions (HHS Only)
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- CIT Spring Town Hall 2012 (NIH Only)
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- - CIT (2012/03/25)
- - Category : NIH Only
- Spring Town Hall 2012
CIT Spring Town Hall 2012 (NIH Only)
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- CC Grand Rounds: Behcets Disease: An Enigma Revisited
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- - (1) Cailin Henderson Sibley, MD, Staff Clinician, Translational Autoinflammatory Disease Section, NIAMS(2) Elaine F. Remmers, PhD, Staff Scientist, Inflammatory Disease Section, Medical Genetics Branch, NHGRI (2012/03/24)
- - Category : Clinical Center Grand Rounds
- CC Grand Rounds: Behcets Disease: An Enigma Revisited
For more information go to http://www.cc.nih.gov/about/news/grcurrent.html
CC Grand Rounds: Behcets Disease: An Enigma Revisited
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- Demystifying Medicine- Cancer of the Head and Neck: new paradigms and treatment
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- - Silvio Gutkind, Carter Van Waes (2012/03/23)
- - Category : Demystifying Medicine
- The course includes presentation of patients, pathology, diagnosis and therapy in the context of major disease problems and current research. Primarily directed toward Ph.D. students, fellows, and staff, it is also of interest to medical students and clinicians. The course is designed to help bridge the gap between advances in biology and their application to major human diseases. Each session includes clinical and basic science components which are presented by NIH staff and outside invitees.
For more information go to http://demystifyingmedicine.od.nih.gov/
Demystifying Medicine- Cancer of the Head and Neck: new paradigms and treatment
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- Mitochondrail DNA: Prometheus Gift or Pandoras Box?
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- - Dr. Salvatore DiMauro, Columbia University Medical Center (2012/03/23)
- - Category : Wednesday Afternoon Lectures
- The Greek myth of the giant Prometheus stealing fire from the Olympian gods and giving it to humans, and the gods？？？ ？？？Trojan horse？？？ gift to Prometheus of the beautiful but incorrigibly curious Pandora neatly symbolizes the symbiotic origin of mitochondrial DNA (mtDNA) and its role in human health and pathology (including aging).
I will review our relatively recent awareness of mtDNA and our even more recent discovery of its important role in human pathology. The first two pathogenic mutations in mtDNA were reported in 1988: 24 years later, over 200 point mutations and innumerable deletions have been associated with an extraordinary variety of human disorders, most of them multisystemic (？？？mitochondrial encephalomyopathies？？？) but some tissue-specific (for example, mitochondrial myopathies). After a brief reminder of the unique rules of mitochondrial genetics, I will propose a genetic classification of the mitochondrial disorders and provide examples of different mtDNA-related diseases. As a myologist by training, I feel obliged to stress the importance of the muscle biopsy in our diagnostic approach to mitochondrial diseases. As mtDNA mutations are so common, it is important to recognize which are pathogenic and which are neutral polymorphisms. I will, therefore, review and provide examples of the ？？？canonical？？？ criteria of mtDNA pathogenicity, including heteroplasmy, single fiber PCR, and the cybrid technology.
In 2000, I wrote a review titled ？？？Mutations in mtDNA: are we scraping the bottom of the barrel?？？？ (Brain Pathology 2000:10:431-441). I will proceed to show that we are far from scratching the bottom of the barrel. We are still debating the frequency of mtDNA-related disorders; novel mutations or novel clinical phenotypes are still being reported at a brisk pace; the role of homoplasmic pathogenic mutations is not yet fully understood; similarly, the modulating role of mtDNA haplotypes is still being described; and ？？？ importantly ？？？ the pathogenic mechanism of mtDNA mutations is not yet understood (in other words, we still do not understand why MELAS differs from MERRF when both syndromes are due to mutations in mtDNA tRNA genes). It has been aptly said that mtDNA is the slave of nuclear DNA (nDNA), in that, in the course of the millennia, mtDNA has lost most of its original autonomy and now depends heavily on nuclear DNA for its basic functions, including replication and maintenance. Thus, besides disorders (reviewed above) due to ？？？primary？？？ mtDNA mutations, there are many disorders due to mutations in nuclear genes controlling mtDNA replication (mtDNA depletion syndromes), mtDNA maintenance (multiple mtDNA deletions syndromes) or mtDNA translation. These ？？？indirect hits？？？ (defects of intergenomic communication) are transmitted as mendelian traits but have genetic features that overlap with mitochondrial genetics. Thanks to new generation mitoexome sequencing, the neat subdivision between mtDNA depletion and multiple mtDNA syndromes is crumbling, as mutations in the same genes (usually involved with the homeostasis of the mitochondrial nucleotide pool) can impair either mtDNA replication or maintenance (or both).
In a provocative article, the late Anita Harding wondered whether normal aging wasn？？？t the most common mitochondrial disease of them all. There is considerable evidence that this is true and largely due to spontaneous accumulations of mtDNA deletions in postmitotic tissues.
Finally, although I don？？？t have the time to review therapeutic strategies, I will consider a potentially preventive approach to mtDNA-related diseases, namely cytoplasmic transfer. Although successful in primates and 2in preliminary experiments with defective human oocytes, this therapeutic modality requires careful ethical screening.
The NIH Wednesday Afternoon Lecture Series includes weekly scientific talks by some of the top researchers in the biomedical sciences worldwide.
For more information, visit:
The NIH Directors Wednesday Afternoon Lecture Series
Mitochondrail DNA: Prometheus Gift or Pandoras Box?
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- The Pressure to Get It Right: Biases in Biomedical Research
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- - John Ioannidis, MD, DSc, Stanford Prevention Research Center (2012/03/22)
- - Category : Special
- Medicine: Mind the Gap An NIH Seminar Series
Dr. Ioannidis will discuss the empirical evidence for the presence and consequences of some main biases in scientific discovery. He will also discuss solutions for optimizing the efficiency of the biomedical research processes. The intensified quest for scientific discovery has resulted in a flurry of research claims that represent false positive or exaggerated results. There are many forces that create this excess of spurious significant findings, including both random error and a number of biases. Dr. Ioannidis talk will address all of these pertinent issues.
Dr. Ioannidis is currently the C.F. Rehnborg Professor in Disease Prevention, Professor of Medicine and Director of the Stanford Prevention Research Center at Stanford University School of Medicine. He has been adjunct faculty for the Tufts University School of Medicine since 1996, with the rank of professor since 2002, and since 2008 he has been leading the Center for Genetic Epidemiology and Modeling, of the Tufts Institute for Clinical Research and Health Policy Studies and the Genetics/Genomics component at the Tufts CTSI. He is also adjunct professor of epidemiology at the Harvard School of Public Health and visiting professor of epidemiology and biostatistics at Imperial College London. Dr. Ioannidis has served as a member of the executive board of the Human Genome Epidemiology Network, President of the Society for Research Synthesis Methodology, editorial board member of 26 leading international journals, and Editor-in-Chief of the European Journal of Clinical Investigation. He has published peer-reviewed papers, books and book chapters, papers such as the one in PLoS Medicine, ？？？Why most Published Research Findings are False (2005). He has received several awards, including the European Award for Excellence in Clinical Science for 2007 and he has been inducted into the Association of American Physicians and the European Academy of Cancer Sciences. His work combines skills in clinical research methodology and evidence-based medicine with the challenges of current molecular medicine and genomics.
This seminar is sponsored by the Office of Disease Prevention, National Heart, Lung, and Blood Institute, National Institute on Alcohol Abuse and Alcoholism, and National Cancer Institute Division of Cancer Prevention.
For more information about this seminar, visit
http://consensus.nih.gov/mindthegap/Ioannidis.htm
The Pressure to Get It Right: Biases in Biomedical Research
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- Plasticity and Regeneration in the CNS; the Role of the Extracellular Matrix
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- - James Fawcett, PhD, University of Cambridge, UK (2012/03/22)
- - Category : Neuroscience
- Neuroscience Seminar Series
Dr. Fawcetts Lab work concerns the role of extracellular matrix proteoglycans in the central nervous system. In the damaged CNS, they are trying to understand how axonal growth is inhibited by the increased expression of inhibitory proteoglycans, and how to overcome this inhibition. They work on how to increase the intrinsic regenerative potential of axons, using integrin engineering and local protein translation. In addition, plasticity is turned off in adults by extracellular matrix structures called perineuronal nets. They work on the actions of these structures, and methods to modulate their function so as to improve functional recovery and memory in the adult CNS.
For more information go to http://neuroseries.info.nih.gov
Plasticity and Regeneration in the CNS; the Role of the Extracellular Matrix
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- Identification of Small Molecule Inhibitors of DNA Polymerase Kappa.
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- - Dr R. Stephen Lloyd and Dr Maureen Hoatlin (2012/03/22)
- - Category : DNA Repair
- DNA Repair Interest Group
Origin OHSU, Portland, OR
Identification of Small Molecule Inhibitors of DNA Polymerase Kappa.
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- Big man on campus: Social regulation of gene and endocrine expression in human and non-human primates
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- - Jeanne Altmann, Princeton University and Steven W Cole, University of California (2012/03/22)
- - Category : Oppnet
- OppNet
NIHs Basic Behavioral and Social Science Opportunity Network (OppNet) presents its fourth symposium on Human and Model Animal Research in the Basic Behavioral and Social Sciences.
This series brings together scientists who conduct research on similar topics--at minimum, one researcher with human subjects, another with model animals. After individual presentations, the presenters, hosts and symposium participants will discuss areas of interest and potential future directions.
Jeanne Altmann, Ph.D.
Emeritus Professor and Research Scholar
Eugene Higgins Professor of Ecology and Evolutionary Biology
Department of Ecology and Evolutionary Biology, Princeton University
Title: Social regulation of health and well-being in wild baboons: mechanism and outcomes.
Steven W Cole, Ph.D.
Professor of Medicine
Division of Hematology-Oncology
Norman Cousins Center
University of California, Los Angeles
Title: Social regulation of human gene expression.
For more information go to http://oppnet.nih.gov
Big man on campus: Social regulation of gene and endocrine expression in human and non-human primates
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- Novel Omega-3 Mediators & Mechanisms in the Resolution of Inflammation: What Can they Tell us About Preventative and Therapeutic Approaches?
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- - Dr. Charles N. Serhan, Harvard University (2012/03/21)
- - Category : Stars in Nutrition
- Stars in Nutrition and Cancer
Objectives
Define the functional differences between anti-inflammation versus pro-resolution and the cell types involved;
Define the anti-inflammatory and pro-resolving lipid mediators; Review the biosynthesis and omega-3 precursors (EPA and DHA) of the resolvins, protectins and maresins (E-series vs. D-series resolvins) and their actions;
Define the resolution indices: what enhances resolution and the drugs that are resolution toxic; and
What are the key cellular targets of the resolvins and mechanism(s) (e.g. receptors, miR, etc.) that define resolving autacoids in animal inflammatory diseases.
For more information go to http://prevention.cancer.gov/news-events/events/20120313
Novel Omega-3 Mediators & Mechanisms in the Resolution of Inflammation: What Can they Tell us About Preventative and Therapeutic Approaches?
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- Easy Tips on How to Reduce the Sodium in Your Favorite Recipes
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- - Chef Lucy White, Dr. Margaret McDowell, Dr. Michael Donovan (2012/03/21)
- - Category : Focus on You Wellness
- The Office of Research Services, Eurest Dining Services, NIH Division of Nutrition Research and Coordination, the NIH Health and Wellness Council and the NIH R&W Fitness and Wellness Program are proud to present a fun cooking demonstration in observance of March as National Nutrition Month with:
？？？Easy Tips on How to Reduce the Sodium in Your Favorite Recipes？？？ presented by Chef Lucy White, RD.
Join us on discover clever and interesting tips on how to reduce sodium in your daily diet.
For more information, visit
http://dats.ors.od.nih.gov/wellness/index.htm
Easy Tips on How to Reduce the Sodium in Your Favorite Recipes
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- Catalytic and Gene Regulatory RNAs: Structural Biology, Physiology, and Evolution
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- - Adrian Ferre-DAmare, Ph.D., Biochemistry and Biophysics Center, NHLBI (2012/03/21)
- - Category : NIH Directors Seminars
- NIH Directors Seminar Series
Education: Adrian Ferr？？-DAmar？？ received his B.S. in chemistry from the Instituto Tecnol？？gico de Monterrey, in Mexico, and his Ph.D. in molecular biophysics from the Rockefeller University. He has been named a Rita Allen Foundation Scholar and a W.M. Keck Foundation Distinguished Young Scholar in Medical Research.
Research Interests:
Despite its chemical simplicity (compared to proteins) RNA can fold into intricate three-dimensional structures that can recognize other RNAs, proteins and small molecules with high affinity and specificity and carry out biological catalysis. We employ structural, biophysical, biochemical, and in vitro genetic techniques, as well as chemical synthesis, to study ribozymes, riboswitches, and ribonucleoprotein complexes.
We study ribozymes (catalytic RNAs), both cellular and in vitro selected, because they starkly demonstrate the chemical versatility of this nucleic acid. We study riboswitches. These are RNA elements of non-coding regions of messenger RNAs that can switch between two functional states, depending on whether they are bound to a metabolite. Riboswitches are used by bacteria and eukaryotes to regulate gene expression at the transcriptional, post-transcriptional, and translational levels. We study protein enzymes responsible for post-transcriptional modification of RNAs. These modifications expand the chemical repertoire of the nucleic acid; the enzymes responsible may also serve as chaperones, facilitating RNA folding in vivo. We study a family of protein enzymes called pseudouridine synthases. These are responsible for the most abundant and phylogenetically conserved modification of cellular RNAs.
For more information, visit: http://www.nih.gov/about/director/dirsem.htm
Catalytic and Gene Regulatory RNAs: Structural Biology, Physiology, and Evolution
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- 2012 Workshop for Postdocs Transitioning to Independent Positions (Day 1)
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- - Featured Keynote Speaker - Dr. Francis Collins, NIH Director (2012/03/18)
- - Category : Conferences
- This workshop is intended to bring together approximately 150 postdoctoral investigators who will soon be seeking their first independent positions. While the transition to independence is a challenge for all postdocs, young investigators who are members of groups that are underrepresented in the biomedical or behavioral sciences may have an especially difficult time finding and establishing themselves in their first independent positions. For this reason, emphasis will be placed on members of these groups.
2012 Workshop for Postdocs Transitioning to Independent Positions (Day 1)
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- 2012 Workshop for Postdocs Transitioning to Independent Positions (Day 2)
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- - Featured Keynote Speaker - Dr. Francis Collins, NIH Director (2012/03/18)
- - Category : Conferences
- This workshop is intended to bring together approximately 150 postdoctoral investigators who will soon be seeking their first independent positions. While the transition to independence is a challenge for all postdocs, young investigators who are members of groups that are underrepresented in the biomedical or behavioral sciences may have an especially difficult time finding and establishing themselves in their first independent positions. For this reason, emphasis will be placed on members of these groups.
2012 Workshop for Postdocs Transitioning to Independent Positions (Day 2)
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- NIH Back-Up Care Program: What You Need To Know
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- - Linda McDonald and Liz Despres (2012/03/18)
- - Category : Parenting
- Attend this seminar to learn about the new NIH Back-Up Care Program, including how to register and how to reserve care. When your regular child or adult/elder care arrangements are unavailable you will now have access to the Bright Horizons Back-Up Care Advantage Program. This service provides center-based child care, in-home child care, in-home mildly ill child care, and in-home adult/elder care.
Presentation Slides
Handout Slides
For more information go to http://childcare.ors.nih.gov
NIH Back-Up Care Program: What You Need To Know
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- NCI Center for Global: Setting Priorities for Global Cancer Research - Congressional Ballroom (Day 1)
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- - NCI Center for Global Health (2012/03/17)
- - Category : Conferences
- NCI Center for Global Health has organized a meeting with internal and external stakeholders for the purposes of gathering input on global cancer research and NCIs global initiatives portfolio.
NCI Center for Global: Setting Priorities for Global Cancer Research - Congressional Ballroom (Day 1)
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- NCI Center for Global: Setting Priorities for Global Cancer Research - Grand Saloon D and E at Marriott (Day 1)
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- - NCI Center for Global Health (2012/03/17)
- - Category : Conferences
- NCI Center for Global Health has organized a meeting with internal and external stakeholders for the purposes of gathering input on global cancer research and NCIs global initiatives portfolio.
NCI Center for Global: Setting Priorities for Global Cancer Research - Grand Saloon D and E at Marriott (Day 1)
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- Careers in Biodefense (NIH Only)
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- - Fred Steinberg, Senior Advisor, MITRE; Christy Tomlinson, Senior Scientist, Schafer Corporation; Terry Taylor, President of the International Council for the Life Sciences; Gianluca Pegoraro, Research Scientist with the Geneva Foundation, US Army Research Insititute for Infectious Diseases (USAMRIID) (2012/03/17)
- - Category : NIH Only
- Are you interested in a career which will help protect armed forces and civilians to prepare a response to a biological attack? If so, then this is the panel to attend. Following September 11 and the anthrax letters in 2001, the field of biodefense significantly expanded to address global health, public preparedness and response, medical countermeasure development, and biological research. The increasing investment in biodefense and concern about a bioterrorism attack within the United States and abroad has expanded the job market in this field. This panel will explore different types of careers (both at and away from the bench) in the biodefense field for both government and non-government institutions. With speakers from a variety of backgrounds, attendees will learn about the diverse opportunities within this field as well as the entry requirements for available careers. This event is sponsored by FELCOMs Career Development Subcommittee.
For more information go to https://ww.training.nih.gov
Careers in Biodefense (NIH Only)
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- NCI Center for Global: Setting Priorities for Global Cancer Research (Day 2)
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- - NCI Center for Global Health (2012/03/17)
- - Category : Conferences
- NCI Center for Global Health has organized a meeting with internal and external stakeholders for the purposes of gathering input on global cancer research and NCIs global initiatives portfolio.
NCI Center for Global: Setting Priorities for Global Cancer Research (Day 2)