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  • Contemporary Clinical Medicine: Great Teachers: Musical Reading and Writing: Neurology of Music
    • - John C. Brust, MD, Professor of Neurology, Columbia University College of Physicians and Surgeons (2012/03/17)
    • - Category : Clinical Center Grand Rounds
    Great Teachers: Musical Reading and Writing: Neurology of Music


    For more information go to http://www.cc.nih.gov/about/news/grcurrent.html

    Contemporary Clinical Medicine: Great Teachers: Musical Reading and Writing: Neurology of Music

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  • A New Look at Peripheral Tolerance, or, Good Genes Behaving Badly
    • - C. G. (Garry) Fathman, MD, Stanford University School of Medicine (2012/03/17)
    • - Category : Wednesday Afternoon Lectures
    Understanding the pathogenesis of T1D should facilitate the development of novel disease biomarkers and therapeutics that can accomplish a stated goal of NIDDK, to block T1D progression before complete  cell destruction. The major emphasis placed on disease associated genetic mutations or polymorphisms to understand the genetics of T1D has failed to advance either understanding of T1D pathogenesis or to identify therapeutic targets. Recent studies from the Fathman lab have demonstrated that tissue- and disease-specific changes in mRNA expression, rather than DNA variants, may underlie the progression of T1D. Work to be presented emphasizes the importance of studying the control of tissue-specific gene expression in relationship to the pathogenesis of T1D. By combining their expertise in T1D research with their established preclinical models and patient samples/tissues from their collaborator, the Network for Pancreatic Organ Donors with Diabetes, nPOD http://www.jdrfnpod.org, Fathman and colleagues have both demonstrated a potential defect in peripheral tolerance in NOD mice that has homologies in T1D patients and have demonstrated that appropriate immunotherapy may overcome this defect

    The NIH Wednesday Afternoon Lecture Series includes weekly scientific talks by some of the top researchers in the biomedical sciences worldwide.

    For more information, visit:
    The NIH Directors Wednesday Afternoon Lecture Series

    A New Look at Peripheral Tolerance, or, Good Genes Behaving Badly

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  • Noise Correlations and Neural Coding
    • - Fred Rieke, PhD, University of Washington (2012/03/16)
    • - Category : Neuroscience
    Neuroscience Seminar Series

    Research in the Rieke lab focuses on sensory signal processing, particularly in cases where sensory systems perform at or near the limits imposed by physics. Photon counting in the visual system is a beautiful example. At its peak sensitivity, the performance of the visual system is limited more by the division of light into discrete photons than by biological noise or inefficiencies. This observation guides the labs investigation of the underlying mechanisms. Some of the current questions in the lab:

    ？？？ What are the limits to visual sensitivity imposed by noise in the rod and cone photoreceptors? How close does the retina come to realizing these limits?
    ？？？ How does the retinal circuitry read out the photoreceptor signals? Are there specializations for signals from rod and cone photoreceptors?
    ？？？ How does the retina adapt and maintain sensitivity when the mean or contrast of the light inputs change?

    For more information go to http://neuroseries.info.nih.gov

    Noise Correlations and Neural Coding

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  • STEP Im Not aSLEEP... But that Doesnt Mean Im Awake (HHS Only)
    • - Sonia Jakowlew, Terri Jarosik (2012/03/16)
    • - Category : STEP (HHS Only)
    How much sleep do you really need? We all know people who seem to need only 4 or 5 hours of sleep, but are they functioning at an optimal level? Sleep affects every aspect of your life -- mood, emotions, memory, physiology and public safety. Join us to learn about the latest scientific findings on sleep, sleep impairment, long term effects of sleep deprivation, and treatment strategies.

    For more information, visit: http://esa.nih.gov/oer/training/step/step_training_20120313.htm

    STEP Im Not aSLEEP... But that Doesnt Mean Im Awake (HHS Only)

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  • Cell-Material Integration Research at iCeMS for Pluripotent Stem Cell Science and Technology
    • - Norio Nakatsuji, PhD, Kyoto University, Japan (2012/03/16)
    • - Category : Stem Cell
    NIH CRM/SCIG Stem Cell Seminar Series:

    Cell-Material Integration Research at iCeMS forPluripotent Stem Cell Science and Technology
     
    Norio Nakatsuji
    Professor and Director
    Institute for Integrated Cell-Material Sciences (iCeMS), Kyoto University, Japan
     
    The iCeMS was founded as a global researchinstitute of Kyoto University in 2007 for advancement of cross-disciplinaryresearch by integration of cell biology, chemistry and physics. Our targeteddirections are (1) stem cell science and technology focusing on pluripotentstem cells (ES/iPS cells) and (2) creation of novel scientific fields of themesoscopic domain which is the intersection between materials and living cells.
     
    Our research activities toward medical and pharmaceuticalapplications of stem cells include chemical screening to discover novel toolsand probes for stem cell control, design/synthesis of smart functional compoundsand materials for cell growth and differentiation, and creation of model cellssuch as neurodegenerative disease models. Now, we are developing technology forlarge-scale production of high quality human pluripotent stem cells bycollaboration with several high-technology companies in a government-supportedproject.

    Cell-Material Integration Research at iCeMS for Pluripotent Stem Cell Science and Technology

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  • Demystifying Medicine- Hepatocellular cancer: a global disease
    • - Jean Pierre Gillet, Itzhak Avital, Win Arias (2012/03/16)
    • - Category : Demystifying Medicine
    The course includes presentation of patients, pathology, diagnosis and therapy in the context of major disease problems and current research. Primarily directed toward Ph.D. students, fellows, and staff, it is also of interest to medical students and clinicians. The course is designed to help bridge the gap between advances in biology and their application to major human diseases. Each session includes clinical and basic science components which are presented by NIH staff and outside invitees.

    For more information go to http://demystifyingmedicine.od.nih.gov/

    Demystifying Medicine- Hepatocellular cancer: a global disease

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  • 16th Meeting of the NCI Clinical Trials and Translational Research Advisory Committee (CTAC)
    • - NCI Coordinating Center for Clinical Trials (2012/03/15)
    • - Category : Clinical Trials and Translational Research Advisory Committee
    CTAC provides advice to the Director, NCI, NCI Deputy Directors, and the Director of each NCI Division on the NCI-supported national clinical trials enterprise to build a strong scientific infrastructure by bringing together a broadly developed and engaged coalition of stakeholders involved in the clinical trials process. In addition, the Committee makes recommendations related to the effectiveness of NCI's translational research management.

    16th Meeting of the NCI Clinical Trials and Translational Research Advisory Committee (CTAC)

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  • RECOMBINANT DNA ADVISORY COMMITTEE MEETING (Day 1)
    • - NCI (2012/03/15)
    • - Category : Recombinant DNA Advisory Committee
    NATIONAL INSTITUTES OF HEALTH, RECOMBINANT DNA ADVISORY COMMITTEE 128TH MEETING, MARCH 7-8, 2012

    For more information go to http://oba.od.nih.gov/rdna_rac/rac_meetings.html

    RECOMBINANT DNA ADVISORY COMMITTEE MEETING (Day 1)

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  • RECOMBINANT DNA ADVISORY COMMITTEE MEETING (Day 2)
    • - NCI (2012/03/15)
    • - Category : Recombinant DNA Advisory Committee
    128TH RECOMBINANT DNA ADVISORY COMMITTEE MEETING

    For more information go to http://oba.od.nih.gov/rdna_rac/rac_meetings.html

    RECOMBINANT DNA ADVISORY COMMITTEE MEETING (Day 2)

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  • Demystifying Medicine- Aging Gracefully
    • - Toren Finkel, Luigi Ferrucci (2012/03/13)
    • - Category : Demystifying Medicine
    The course includes presentation of patients, pathology, diagnosis and therapy in the context of major disease problems and current research. Primarily directed toward Ph.D. students, fellows, and staff, it is also of interest to medical students and clinicians. The course is designed to help bridge the gap between advances in biology and their application to major human diseases. Each session includes clinical and basic science components which are presented by NIH staff and outside invitees.

    For more information go to http://demystifyingmedicine.od.nih.gov/

    Demystifying Medicine- Aging Gracefully

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  • Innovative Approaches to Clinical Trials
    • - Robert M. Califf, MD (2012/03/13)
    • - Category : Special
    Medicine: Mind the Gap An NIH Seminar Series

    Innovative Approaches to Clinical Trials

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  • Targeting Aging to Delay Multiple Chronic Diseases: A New Frontier
    • - James Kirkland, M.D., Ph.D., Professor of Medicine and of Physiology, Mayo Clinic (2012/03/11)
    • - Category : Special
    Geroscience Interest Group

    The Geroscience Interest Group (GSIG) cordially invites you to the seminar listed above. Dr. Kirkland is Professor of Medicine and Physiology and Director of the Robert and Arlene Kogod Center on Aging at the Mayo Clinic in Rochester, Minnesota. His research interests include the effect of aging on preadipocyte differentiation and function, and the role of fat tissue on age-related dysfunction, lifespan and healthspan. His recent paper in Nature, describing amelioration of several age-related phenotypes in mice after removal of senescent cells, gained considerable media attention and was selected by Science among the top 10 discoveries of 2011. In addition to this work, Dr. Kirkland will talk more extensively on the role of aging biology as the major risk factor for most chronic diseases.

    The Geroscience Interest Group (GSIG) is a newly formed trans-NIH group aimed at enhancing opportunities for discussion of the intersection between the biology of aging and the biology of diseases and conditions that are of interest across ICs. It is focused on basic biology, but with a longer view towards translation. If you are interested in learning more, please visit the GSIG web site
    http://sigs.nih.gov/geroscience/Pages/default.aspx

    Targeting Aging to Delay Multiple Chronic Diseases: A New Frontier

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  • CC Grand Rounds: (1) Allergic Disease and the Environment (2) Genome-wide Association Studies and Environmental Interactions in Pulmonary Function
    • - (1) Darryl Zeldin, MD, Senior Investigator and Scientific Director, NIEHS (2) Stephanie London, MD, Senior Investigator, Epidemiology Branch and Laboratory of Respiratory Biology, NIEHS (2012/03/10)
    • - Category : Clinical Center Grand Rounds
    (1) Allergic Disease and the Environment (2) Genome-wide Association Studies and Environmental Interactions in Pulmonary Function


    For more information go to http://www.cc.nih.gov/about/news/grcurrent.html

    CC Grand Rounds: (1) Allergic Disease and the Environment (2) Genome-wide Association Studies and Environmental Interactions in Pulmonary Function

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  • Wizardry of Tissue Repair and Regeneration: A Tale of Skin Cells when their Magic is all but Gone
    • - Marjana Tomic-Canic, Ph.D., R.N., University of Miami Miller School of Medicine (2012/03/10)
    • - Category : Wednesday Afternoon Lectures
    Current research focus of Dr. Tomic-Canic is molecular and cellular mechanisms of wound healing and its inhibition with the long-term goal to bring bench-side research back to patients at the bedside. Her research includes human and diabetic models of wound healing, wound genomics analyses, generating primary cells from patients？？？ wound biopsies, local sustained gene delivery, cellular assays of wound healing, and histology and immunohistochemistry of skin. Dr. Tomic-Canic and her colleagues, supported in part by NINR, made several fundamental discoveries in the field of wound healing research. These discoveries include identification of the one of the first genes and unique molecular pathway that stops wounds from healing; a novel molecular mechanism though which corticosteroids inhibit wound healing; biomarkers that can guide the extent surgical debridement; establishment of human wound tissue/cell bank; new drugs that accelerate healing. Dr Tomic-Canic has an established track record of successfully bringing basic science discovery to clinical use for wound patients. Her lab has identified molecular markers that may predict clinical outcome of non-healing and guide surgical debridement of chronic ulcers, which are currently being validated in an NIH-sponsored clinical trial.

    The NIH Wednesday Afternoon Lecture Series includes weekly scientific talks by some of the top researchers in the biomedical sciences worldwide.

    For more information, visit:
    The NIH Directors Wednesday Afternoon Lecture Series

    Wizardry of Tissue Repair and Regeneration: A Tale of Skin Cells when their Magic is all but Gone

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  • Leadership Group for a Clinical Research Network on Antibacterial Resistance: Information Session
    • - NIAID (2012/03/09)
    • - Category : Conferences
    The National Institute of Allergy and Infectious Diseases (NIAID) is supporting a new clinical research program focused on antibacterial resistance, and will provide information on related scientific and administrative issues to viewers during this videocast.

    Leadership Group for a Clinical Research Network on Antibacterial Resistance: Information Session

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  • Core Curriculum 3 - Review Policies and Procedures (HHS Only)
    • - Chuck Selden (2012/03/09)
    • - Category : Core Curriculum (HHS Only)
    Agenda
    1. Introduction: use the correct policy information

    2. Pre-meeting: Assessing the task, administrative review, and planning

    3. Pre-meeting: Identifying the appropriate expertise and making review assignments

    4. Pre-meeting: laying the foundation for a successful review meeting

    5. Review Meeting: your role is central in orchestrating a successful meeting

    6. Post-meeting: documenting and informing

    7. Appeals to Peer Review

    8. Additional Resources

    9. Case Studies
    Faculty Roster

    For more information, visit: http://esa.nih.gov/oer/training/esa/esa_cores_2012.htm

    Core Curriculum 3 - Review Policies and Procedures (HHS Only)

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  • Umbilical cord blood: A novel therapy for genetic and acquired brain injuries
    • - Joanne Kurtzberg, MD, Duke University Medical Center (2012/03/09)
    • - Category : Stem Cell
    NIH CRM/SCIG Stem Cell Seminar Series:
    Speaker: 
    Joanne Kurtzberg, MD
    Title: 
    Umbilical cord blood: A novel therapy for genetic and acquired brain injuries
    Affiliation:
    Jerome Harris Distiguished Professor of Pediatrics
    Professor of Pathology
    Duke University Medical Center

    Umbilical cord blood: A novel therapy for genetic and acquired brain injuries

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  • The Mirror of Mechanism: A Neural Mechanism for Understanding Others
    • - Giacomo Rizzolatti, MD, University of Parma, Italy (2012/03/07)
    • - Category : Neuroscience
    Neuroscience Seminar Series

    Dr. Rizzolatti Labs research concerns mostly the cognitive function of the motor system. They address this issue in monkeys and humans. In monkeys, they study the anatomical and functional organization of ventral and dorsal premotor cortex (single neuron recording) and the global organization of the grasping mirror circuit (fMRI experiments). In humans, they investigate the relations between the mechanism mediating the understanding of the goal of the observed actions and those involved in the pictorial description of the same actions (EEG, TMS techniques). Part of their research in humans is devoted to the study of autism and in particular to the way children with autism understand the action and intention of others (behavioral and fMRI experiments). Their basic research is supported by European grants (European Research Council, ERC) and by the Italian Institute of Technology (IIT), while their applied research is supported by private foundations (Fondazione Banca Monte, Fondazione Cariparma).

    For more information go to http://neuroseries.info.nih.gov

    The Mirror of Mechanism: A Neural Mechanism for Understanding Others

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  • NIH Rare Disease Day 2012
    • - ORDR (2012/03/04)
    • - Category : Conferences
    On February 29, 2012, the National Institutes of Health (NIH) will celebrate the fifth annual Rare Disease Day with a day-long celebration and recognition of the various rare diseases research activities supported by the NIH Office of Rare Diseases Research, the NIH Clinical Center, other NIH Institutes and Centers; the Food and Drug Administration？？？s Office of Orphan Product Development; the National Organization for Rare Disorders; and the Genetic Alliance. Rare Disease Day at NIH (RDD@NIH) will be held in the Clinical Center？？？s Masur Auditorium (Building 10) from 8:30 a.m. to 5:00 p.m. Attendance is free and open to the public.

    For more information go to http://rarediseases.info.nih.gov/RareDiseaseDay.aspx

    NIH Rare Disease Day 2012

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  • Cancer Genomes and Their Implications for Basic and Applied Research (NIH Only)
    • - Bert Vogelstein, M.D., Johns Hopkins University School of Medicine (2012/03/03)
    • - Category : NIH Only
    The 2012 Jeffrey M. Trent Lectureship in Cancer Research

    Dr. Trent was the National Human Genome Research Institutes founding scientific director, serving in this role for more than nine years. His leadership and vision was instrumental in establishing NHGRIs Division of Intramural Research as one of the premier research programs in the world devoted to genetics and genomics. In recognition of his significant contributions to the research environment at NIH, NHGRI established the annual Jeffrey M. Trent Lectureship in Cancer Research in 2003. This lecture is given by a prominent cancer researcher who brings the kind of energy, creativity and enthusiasm to cancer research that Dr. Trent has exemplified throughout his career.

    The presenter is Bert Vogelstein, M.D., Clayton Professor of Oncology and Pathology, and director of the Ludwig Center for Cancer Genetics and Therapeutics at the Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine. Dr. Vogelstein is also a Howard Hughes Medical Institute investigator. The lecture is convened by the National Human Genome Research Institutes Division of Intramural Research, and will be held at the Natcher Conference Center (Building 45) on the National Institutes of Health (NIH) campus in Bethesda, Md.

    Dr. Vogelstein was the first researcher to elucidate the molecular basis of a common human cancer. His work on colorectal cancers forms the paradigm for much of modern cancer research, with profound implications for diagnostic and therapeutic strategies in the future.

    Excellent academic and medical training set the foundation for Dr. Vogelsteins illustrious science career. He earned his medical degree at the Johns Hopkins University School of Medicine and completed his residency in pediatrics at the Johns Hopkins Hospital. Following his clinical training, Dr. Vogelstein also completed a post-doctoral fellowship at the National Cancer Institute, focusing on the development of new approaches to the study of human cancers.

    Dr. Vogelstein has received numerous awards recognizing his pioneering studies on the pathogenesis of human cancers. He is a member of the American Academy of Arts and Sciences, the National Academy of Sciences, the American Philosophical Society, the Institute of Medicine and the European Molecular Biology Organization (EMBO). His advisory roles have included chairmanships for the National Research Council Committee on the Biological and Biomedical Applications of Stem Cell Research and the Board of Scientific Counselors of the National Human Genome Research Institute (NHGRI). According to the Institute for Scientific Information, Dr. Vogelstein is currently the most highly cited scientist in the world.

    Cancer Genomes and Their Implications for Basic and Applied Research (NIH Only)

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