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  • Addressing Brain Complexity: Toward a 21st Century CNS Pharmacology
    • - Nathaniel Heintz, PhD, Rockefeller University (2012/01/12)
    • - Category : Neuroscience
    Neuroscience Seminar Series

    Research in Dr. Heintz？？？s laboratory emphasizes the identification of the genes, circuits, cells, macromolecular assemblies and individual molecules that contribute to the function and dysfunction of the mammalian brain. Dr. Heintz and his colleagues have developed a suite of novel approaches based on the manipulation of bacterial artificial chromosomes (BACs) to investigate the histological and functional complexities of the mammalian brain in vivo and to understand how these mechanisms become dysfunctional in disease. For more information, visit

    http://neuroseries.info.nih.gov

    Addressing Brain Complexity: Toward a 21st Century CNS Pharmacology

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  • Geospatial Methods in Health Research
    • - Ellen Cromley, PhD, University of Connecticut School of Medicine (2012/01/08)
    • - Category : BSSR Lecture Series
    BSSR Lecture

    Geospatial methods have established their value in health research and in public health practice over the last 30 years, but there remains great potential for developing the role of these methods in health even further. This presentation outlines key geospatial concepts and their relevance to a broad range of issues in health research design, from study site selection and sampling to data acquisition and analysis to dissemination of findings to research protections for human subjects. The lecture includes an introduction to global and local spatial statistics, spatial regression models, and models of spatially varying processes. The presentation suggests ways to make health research more spatial and better able to uncover from the vast data available the key configurations of factors that come together in particular places to affect our health.

    Ellen Cromley is a medical geographer. She completed a B.A. in Urban and Environmental Studies at Case Western Reserve University, an M.A. in Geography from Ohio State University, and a Ph.D. in geography from the University of Kentucky. She co-authored GIS and Public Health (2002) with Sara McLafferty. The second edition was published in October, 2011. She began her career at Hunter Health Plan in Lexington, Kentucky, a Neighborhood Health Center, and worked for Appalachian Regional Hospitals before her career as a professor in the Department of Geography, University of Connecticut. She spent four years as Senior Research Associate at The Institute for Community Research in Hartford, Connecticut, as an investigator on grants funded by the National Institute of Alcohol Abuse and Alcoholism (alcohol as a factor in sexual risk behavior among young men in slum communities of Mumbai, India), the National Institute on Drug Abuse (housing status and stability among low income drug users in Hartford), and the National Institute of Mental Health (delivery of a multi-level intervention to promote female condom use). She has been a consultant on a research project funded by the National Cancer Institute environmental factors affecting physical activity in older women). Dr. Cromley has served as a career development award mentor for researchers at M.D. Anderson Cancer Center and the University of Connecticut Center for Health, Intervention, and Prevention who were seeking to integrate geographic methods and GIS into their work. She served as a member of the NIH Community-Level Health Promotion study section.

    Geospatial Methods in Health Research

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  • Thats a Fact, Jak: Inhibitors of Janus Kinases as a New Class of Immunomodulatory Drugs
    • - John J. OShea, MD, Scientific Director, NIAMS (2012/01/06)
    • - Category : Clinical Center Grand Rounds
    CC Grand Rounds

    Janus Kinases as a New Class of Immunomodulatory Drugs

    Thats a Fact, Jak: Inhibitors of Janus Kinases as a New Class of Immunomodulatory Drugs

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  • Evolution and Cancer
    • - Dr. David Botstein, Princeton University (2012/01/06)
    • - Category : Wednesday Afternoon Lectures
    There is a broad consensus that cancer is the result of somatic cells having serially gained, by a series of mutations, the ability to grow independently, to recruit resources from the circulation and the stroma, to invade local tissues, and to found anatomically distant metastases, ultimately killing the host. From the point of view of the cancer-causing somatic cell population, this is evolution driven by mutation and selection. Genomics has resulted in a parallel consensus that the central functions of all eukaryotes are highly conserved, not only at the level of individual protein functions, but also complex biological pathways and systems. These ideas motivated a comparison between results of molecular genetic studies of experimental evolution in yeast and the molecular genetic phenomena associated with tumorigenesis and tumor progression. We find some very striking similarities, including recurring genomic rearrangements, alterations of the regulation of specific growth-promoting genes, population-genetic features that affect the fitness trajectories of growth rate variants in evolving populations, and physiological and metabolic similarities derived from the conservation of the basic plan of growth and cell multiplication among all eukaryotes. It is hoped that some of the insights from yeast will aid the interpretation of sequence changes found in tumors, especially in the urgent necessity to distinguish ？？？driver？？？ from ？？？passenger？？？ mutations.？？？

    David Botstein？？？s fundamental contributions to modern genetics include the development of genetic methods for understanding biological functions and the discovery of the functions of many yeast and bacterial genes. In 1980, Botstein and three colleagues proposed a method for mapping human genes that laid the groundwork for the Human Genome Project. The basic principle of the mapping scheme was to develop, by recombinant DNA techniques, random single-copy DNA probes capable of detecting DNA sequence polymorphisms when hybridized to restriction digests, or specific fragments, of an individuals DNA. The method was used in subsequent years to identify several human disease genes, such as Huntingtons and BRCA1. Variations of this method enabled the sequencing phase of the Human Genome Project.

    In the 1990s Botstein, having moved to Stanford University School of Medicine, collaborated with Patrick O. Brown of Stanford in exploiting DNA microarrays to study genome-wide gene expression patterns in yeast and in human cancers. This required developing a new statistical method and graphical interface, widely used today to interpret genomic data. Botstein also has helped to create, with Michael Ashburner and Gerald Rubin, a bioinformatics initiative to unify the representation of gene and gene product attributes across all species, called Gene Ontology. He graduated from Harvard College and earned his doctorate from the University of Michigan. He worked at Massachusetts Institute of Technology from 1967 to 1988; served as vice president for science at Genentech from 1988 to 1990; chaired the Department of Genetics at the Stanford University School of Medicine from 1990 to 2003; and joined the Princeton University faculty in 2003. He has sat on numerous editorial boards and was the founding editor of Molecular Biology of the Cell. Among recent major awards, Bostein won the Peter Gruber Foundation Prize in Genetics in 2003, the Apple Science Innovator Award in 2008, and the Albany Medical Center Prize in 2010.

    The NIH Wednesday Afternoon Lecture Series includes weekly scientific talks by some of the top researchers in the biomedical sciences worldwide.

    For more information, visit: The NIH Directors Wednesday Afternoon Lecture Series

    Evolution and Cancer

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  • National Childrens Study Symposium Health Disparities Among Children of Immigrants (Day 2)
    • - National Childrens Study (2011/12/24)
    • - Category : Conferences
    The National Children？？？s Study (NCS) will examine the effects of the environment, as broadly defined to include factors such as air, water, diet, sound, family dynamics, community and cultural influences, and genetics on the growth, development, and health of children across the United States, following them from before birth until age 21 years. The goal of the study is to improve the health and well-being of children.

    Given the importance of specific influences (for example, family dynamics, community, culture) on immigrant children？？？s health, the National Children？？？s Study Program Office proposes a meeting of subject matter experts to have a dialogue on topics related to immigration as it pertains to the NCS. Subject matter experts will provide comments on potential research questions, process, and measurement strategies that could inform NCS Main Study development and how the health and developmental trajectories of children of immigrants might be addressed.

    For more information, visit: http://www.cvent.com/d/gcqmxp

    National Childrens Study Symposium Health Disparities Among Children of Immigrants (Day 2)

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  • CC Grand Rounds: Advances in Tuberculosis Diagnosis and Therapy: The Next Decade
    • - (1) Henry Masur, Chief, Critical Care Medicine Department, CC (2) Fred M. Gordin, MD, Chief, Infectious Diseases, Veterans Affairs Medical Center, Washington, DC and Professor of Medicine, The George Washington University (2011/12/24)
    • - Category : Clinical Center Grand Rounds
    Clinical Center Grand Rounds

    For more information, visit: http://www.cc.nih.gov/about/news/grcurrent.html

    CC Grand Rounds: Advances in Tuberculosis Diagnosis and Therapy: The Next Decade

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  • National Childrens Study Symposium Health Disparities Among Children of Immigrants (Day 1)
    • - National Childrens Study (2011/12/23)
    • - Category : Conferences
    The National Children？？？s Study (NCS) will examine the effects of the environment, as broadly defined to include factors such as air, water, diet, sound, family dynamics, community and cultural influences, and genetics on the growth, development, and health of children across the United States, following them from before birth until age 21 years. The goal of the study is to improve the health and well-being of children.

    Given the importance of specific influences (for example, family dynamics, community, culture) on immigrant children？？？s health, the National Children？？？s Study Program Office proposes a meeting of subject matter experts to have a dialogue on topics related to immigration as it pertains to the NCS. Subject matter experts will provide comments on potential research questions, process, and measurement strategies that could inform NCS Main Study development and how the health and developmental trajectories of children of immigrants might be addressed.

    For more information, visit: http://www.cvent.com/d/gcqmxp

    National Childrens Study Symposium Health Disparities Among Children of Immigrants (Day 1)

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  • Integrating Genome Maintenance with Cell Cycle Progression via the E3 Ubiquitin Ligase Rad18
    • - Dr. Cyrus Vaziri, Univiversity of North Carolina (2011/12/23)
    • - Category : DNA Repair
    DNA Repair Interest Group videoconference [Origin: NIEHS]

    Integrating Genome Maintenance with Cell Cycle Progression via the E3 Ubiquitin Ligase Rad18

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  • PSC All Hands - December 2011 (HHS Only)
    • - PSC (2011/12/22)
    • - Category : PSC Programs (HHS Only)
    PSC All Hands meeting to discuss accomplishments from FY11 and to look ahead to upcoming initiatives/events.

    PSC All Hands - December 2011 (HHS Only)

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  • Recombinant DNA Advisory Committee 127th Meeting - December 2011 (Day 1)
    • - Dr. Jacqueline Corrigan-Curay (2011/12/21)
    • - Category : Recombinant DNA Advisory Committee
    National Institute of Health (NIH) Recombinant DNA Advisory Committee(RAC) 127th Meeting, Rockville Hilton & Executive Meeting Center

    Recombinant DNA Advisory Committee 127th Meeting - December 2011 (Day 1)

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  • Recombinant DNA Advisory Committee 127th Meeting - December 2011 (Day 2)
    • - Dr. Jacqueline Corrigan-Curay (2011/12/21)
    • - Category : Recombinant DNA Advisory Committee
    NIH RAC 127th Advisory Committee Meeting

    Recombinant DNA Advisory Committee 127th Meeting - December 2011 (Day 2)

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  • Communicating Vaccine Science to the Public
    • - Paul A. Offit, MD, Chief, Division of Infectious Diseases and Director, Vaccine Education Center, Childrens Hospital of Philadelphia and Maurice R. Hilleman Professor of Vaccinology and Professor of Pediatrics, University of Pennsylvania School of Medicine (2011/12/21)
    • - Category : Clinical Center Grand Rounds
    Contemporary Clinical Medicine: Great Teachers Lecture Series

    For more information, visit: http://www.cc.nih.gov/about/news/grcurrent.html

    Communicating Vaccine Science to the Public

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  • RNA Oligonucleotides Conference on Emerging Clinical Applications (Day 1)
    • - Dr. Jacqueline Corrigan-Curay (2011/12/21)
    • - Category : Recombinant DNA Advisory Committee
    RNA Oligonucleotides Conference on Emerging Clinical Applications: sponsored by National Institutes of Health, and Ofiice of Biotechnology Activities

    RNA Oligonucleotides Conference on Emerging Clinical Applications (Day 1)

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  • RNA Oligonucleotides Conference on Emerging Clinical Applications (Day 2)
    • - Dr. Jacqueline Corrigan-Curay (2011/12/21)
    • - Category : Recombinant DNA Advisory Committee
    RNA Oligonucleotides Conference on Emerging Clinical Applications: sponsored by National Institutes of Health, and Ofiice of Biotechnology Activities

    RNA Oligonucleotides Conference on Emerging Clinical Applications (Day 2)

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  • Biomedical Libraries in the Next Decades: Open, Diffuse, and Very Personal
    • - Clifford Lynch, Ph.D. (2011/12/21)
    • - Category : Special
    This talk will look at some of the forces that are reshaping both biomedical informatics and biomedical libraries, and the complex convergence occurring between the two on intellectual and institutional levels as scientific data, traditional publications, and even business and regulatory records are linked together and become the subject of large scale computation. I will also examine radical changes building up in the scholarly publishing system that serves this discipline as a result of these developments. The talk also will briefly discuss ways in which the current unstable consensus about privacy, the advancement of science, database creation and data reuse might shift in the context of broader social developments in health care and citizen science and what that might mean for the knowledge base that supports biomedicine.

    Biomedical Libraries in the Next Decades: Open, Diffuse, and Very Personal

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  • Molecular mechanisms regulating excitatory synapses
    • - Katherine Roche, Ph.D., NINDS, NIH (2011/12/21)
    • - Category : NIH Directors Seminars
    DIRECTORS SEMINAR SERIES

    Dr. Roche received her B.S. from Duke University. In 1995 she received her Ph.D. from Johns Hopkins University, where she worked with Richard Huganir studying the regulation of glutamate receptors. She then did a postdoctoral fellowship with Robert Wenthold in the NIDCD, where she investigated the cell biology of glutamate receptor transport and localization. Dr. Roche joined NINDS as an Investigator in 2001. The main focus of her laboratory is the study of neurotransmitter receptor expression and targeting to the synapse.

    Research Interests:
    Glutamate is the major excitatory neurotransmitter in the mammalian central nervous system, and in addition to its central role in fast excitatory signaling it is also involved in synaptogenesis, synaptic plasticity, and the pathogenesis of certain neurologic diseases. Although glutamate acts as a neurotransmitter in all pathways of the central nervous system, the response to glutamate is not uniform at all glutamatergic synapses and varies with the type of glutamate receptor expressed on the postsynaptic membrane. In this context, we are interested in studying synapse-specific expression of postsynaptic NMDA and metabotropic glutamate receptors. My laboratory characterizes the molecular mechanisms underlying neurotransmitter receptor transport and localization at the synapse using several research strategies which include (1) defining sorting motifs present in neurotransmitter receptor cytosolic domains, (2) isolating neurotransmitter receptor-associated proteins, and (3) determining the role of protein-protein interactions in trafficking and specific synapse localization. Using these cell biological approaches, we hope to elucidate the mechanisms of neurotransmitter receptor trafficking in neurons and the role of accessory proteins at central synapses.

    For more information, visit: http://www.nih.gov/about/director/dirsem.htm

    Molecular mechanisms regulating excitatory synapses

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  • 4th Annual Trauma Spectrum Conference (Day 2)
    • - NIH, DoD and the VA (2011/12/20)
    • - Category : Conferences
    Bridging the Gap Between Research and Clinical Practice of Psychological Health and Traumatic Brain Injury: Prevention, Diagnosis, Treatment and Recovery for the Iraq and Afghanistan Cohort.

    This a 2 day confernce that will focus on advances in PTSD, TBI, and related topics such as substance abuse, pain management, cognitive rehabilitation, neuro-imaging, women's health, and comparative effectiveness research.

    4th Annual Trauma Spectrum Conference (Day 2)

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  • Neural Basis of Strategic Choice
    • - Giorgio Coricelli, PhD, University of Southern California (2011/12/20)
    • - Category : Neuroscience
    Neuroscience Seminar Series

    Dr. Coricelli obtained his PhD in Economics from the University of Arizona. He worked for several years at the Institut des Sciences Cognitives of the CNRS in Lyon, France. He is currently an assistant professor of Economics and Psychology at the University of Southern California. He conduct his research using a fundamentally multidisciplinary approach (Neuroeconomics), drawing from behavioral and experimental economics, game theory, neuroimaging, neuropsychology, and cognitive neurosciences. His objective is to apply robust methods and findings from behavioral decision theory to study the brain structures that contribute to forming judgments and decisions, both in an individual and a social context. Examples of his research are: (1) the role of counterfactual emotions, such as regret and envy, in decision making (fMRI and Orbitofrontal patients studies); (2) the neural basis of bounded rational behavior: limit in depth of strategic reasoning; (3) the neural correlates of individual and social uncertainty: disposition effect, aspiration level, strategic uncertainty; (4) how the brain encodes learning signals: regret/fictive learning, reputation building; (5) impaired decision making in schizophrenia and autism.

    Dr. Coricellis point of view as an economist bring a relevant perspective about how individual performance affect behaviors that are central to social interaction. In particular his work shows how formalism from economics can be applied to studying how emotions and social interactions affect decision making. His work shows that aspects of the formalisms from economics can be combined with learning theory and behavioral analysis to provide more leverage in studying complex individual behavior.

    For more information, visit: http://neuroseries.info.nih.gov

    Neural Basis of Strategic Choice

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  • 2011 David E. Barmes Global Health Lecture: PEPFAR: Moving From Science to Program to Save Lives
    • - Ambassador Eric Goosby, M.D., U.S. Global AIDS Coordinator, U.S. Department of State (2011/12/17)
    • - Category : David E. Barmes
    The Barmes Lecture is the single most important named lecture at NIH on global health. Its purpose is to raise the visibility of global health research issues.

    Ambassador Eric Goosby, M.D., serves as the U.S. Global AIDS Coordinator at the Department of State and as administrator of the President？？？s Emergency Plan for AIDS Relief (PEPFAR). He also manages the federal government？？？s participation in the Global Fund to Fight AIDS, Tuberculosis and Malaria, and serves on the operations committee of the Global Health Initiative.

    His lecture will highlight the work done through PEPFAR, a program launched eight years ago that Goosby currently oversees as ambassador.

    Dr. Goosby has been a pioneer in the fight against AIDS since the earliest days after the epidemic was recognized. He was among the very first physicians to treat people with HIV at San Francisco General Hospital, where he helped to integrate HIV treatment programs with methadone clinics. In 1991, Dr. Goosby moved to Washington to become the first director of the Ryan White CARE program, the nation？？？s domestic HIV care and support initiative. He then became the director of the Office of HIV/AIDS Policy for the Department of Health and Human Services and served in various capacities in the Clinton White House？？？s National AIDS Policy Office, where he helped to establish the Minority AIDS Initiative. He also served as CEO of the Pangea Global AIDS Foundation, which works with governments around the world to establish their own sustainable HIV treatment programs.

    NIH Director Francis S. Collins will deliver introductory remarks at the Barmes Lecture.

    The annual Barmes Lecture honors the late David E. Barmes, special expert for international health at the NIDCR. Prior to joining NIDCR, he served in senior management positions related to oral health, health promotion, and non-communicable diseases at the World Health Organization in Geneva.

    2011 David E. Barmes Global Health Lecture: PEPFAR: Moving From Science to Program to Save Lives

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  • Throwing Transcription for a Loop: The Role of Chromatin Insulators in the 3D Nucleus
    • - Dr. Victor Corces, Emory University (2011/12/17)
    • - Category : Wednesday Afternoon Lectures
    Interactions among regulatory sequences such as enhancers, promoters and insulators give rise to a three-dimensional structure of the genetic material in the eukaryotic nucleus. We have used 5C and HiC to determine the nature of inter- and intra-chromosomal interactions in the Drosophila genome. The results suggest that each chromosome arm is an independent physical unit in terms of its interactions with the rest of the genome. Each chromosome folds into modules with a hierarchical organization. These modules comprise 80% of the genome, they are composed of different types of chromatin, they have a low gene density, and the genes are expressed at low levels, independent of their chromatin composition. Chromosome modules are separated by inter-module regions that comprise 20% of the genome. Inter-module regions have high gene density and comprise different chromatin types, but genes are expressed at higher levels than in chromosome modules. Inter-chromosome modules contain insulator proteins, which, together with RNA polymerase II, mediate interactions with other inter-chromosome modules. Chromosome modules also interact with each other but these interactions are not enriched in any known proteins. We are attempting to deconstruct this 3D structure into specific classes of interactions and determine their role in gene expression. In addition, we are exploring mechanisms by which organization can be regulated. In particular, parylation of insulator proteins appears to regulate interactions among these proteins and the establishment of a specific three-dimensional organization of the chromatin.

    The NIH Wednesday Afternoon Lecture Series includes weekly scientific talks by some of the top researchers in the biomedical sciences worldwide.

    For more information, visit:
    The NIH Directors Wednesday Afternoon Lecture Series

    Throwing Transcription for a Loop: The Role of Chromatin Insulators in the 3D Nucleus

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